HXA2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HXA2_HUMAN
• UniProt AC: O43364
• Protein Name: Homeobox protein Hox-A2
• Gene Name: HOXA2
• Organism: Homo sapiens (Human).
• Sequence Length: 376
• Subcellular Localization: Nucleus.
• Protein Description: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis..
• Protein Sequence: MNYEFEREIGFINSQPSLAECLTSFPPVADTFQSSSIKTSTLSHSTLIPPPFEQTIPSLNPGSHPRHGAGGRPKPSPAGSRGSPVPAGALQPPEYPWMKEKKAAKKTALLPAAAAAATAAATGPACLSHKESLEIADGSGGGSRRLRTAYTNTQLLELEKEFHFNKYLCRPRRVEIAALLDLTERQVKVWFQNRRMKHKRQTQCKENQNSEGKCKSLEDSEKVEEDEEEKTLFEQALSVSGALLEREGYTFQQNALSQQQAPNGHNGDSQSFPVSPLTSNEKNLKHFQHQSPTVPNCLSTMGQNCGAGLNNDSPEALEVPSLQDFSVFSTDSCLQLSDAVSPSLPGSLDSPVDISADSLDFFTDTLTTIDLQHLNY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
80	Phosphorylation	PKPSPAGSRGSPVPA CCCCCCCCCCCCCCC	35.26	22210691
83	Phosphorylation	SPAGSRGSPVPAGAL CCCCCCCCCCCCCCC	22.93	22210691
95	Phosphorylation	GALQPPEYPWMKEKK CCCCCCCCCHHHHHH	14.15	22210691
130	Acetylation	GPACLSHKESLEIAD CCHHHCCHHHEEECC	45.69	19809271
132	Phosphorylation	ACLSHKESLEIADGS HHHCCHHHEEECCCC	35.78	25278378
139	Phosphorylation	SLEIADGSGGGSRRL HEEECCCCCCCHHHH	34.51	25278378
143	Phosphorylation	ADGSGGGSRRLRTAY CCCCCCCHHHHHEEE	19.94	25278378
148	Phosphorylation	GGSRRLRTAYTNTQL CCHHHHHEEECHHHH	28.71	-
151	Phosphorylation	RRLRTAYTNTQLLEL HHHHEEECHHHHHHH	29.35	-
153	Phosphorylation	LRTAYTNTQLLELEK HHEEECHHHHHHHHH	16.88	-
197	Acetylation	WFQNRRMKHKRQTQC HHHHHHHHHHHHHHH	44.13	7407343
205	Acetylation	HKRQTQCKENQNSEG HHHHHHHHHHCCCCC	50.29	7407353

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HXA2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HXA2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HXA2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ZN363_HUMAN	RCHY1	physical	26496426

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.