dbPTM

HUNK_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	HUNK_MOUSE
UniProt AC	O88866
Protein Name	Hormonally up-regulated neu tumor-associated kinase
Gene Name	Hunk
Organism	Mus musculus (Mouse).
Sequence Length	714
Subcellular Localization
Protein Description
Protein Sequence	MPAAAGDGLLGEPAAPGGDGGAEDTTRPAAACEGSFLPAWVSGVSRERLRDFQHHKRVGNYLIGSRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQQMIRHPNITQLLDILETENSYYLVMELCPGGNLMHKIYEKKRLDEAEARRYIRQLISAVEHLHRAGVVHRDLKIENLLLDEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYAAPELLARKKYGPKIDVWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKAMNPLPTQLSTGAVNFLRSLLEPDPVKRPNIQQALANRWLNENYTGKVPCNVTYPNRISLEDLSPSVVLHMTEKLGYKNSDVINTVLSNRACHILAIYFLLNKKLERYLSGKSDIQDSICYKTQLYQIEKCRATKEPYEASLDTWTRDFEFHAVQDKKPKEQEKRGDFLHRPFSKKLDKNLPSHKQPSPSLITQLQSTKALLKDRKASKSGFPDKDSFVCRNLFRKTSDSNCVASSSMEFIPVPPPRTPRIVKKLEPHQPGPGSASILPKEEPLLLDMVRSFESVDREDHIELLSPSHHYRILSSPVSLARRNSSERTLSQGLLSGSTSPLQTPLHSTLVSFAHEEKNSPPKEEGVCSPPPVPSNGLLQPLGSPNCVKSRGRFPMMGIGQMLRKRHQSLQPSSERSLDASMSPLQPTAPSSLSFDMADGVKGQC

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
264	Phosphorylation	LTGTLPFTVEPFSLR HHCCCCCEECCCCHH	23.24	-
269	Phosphorylation	PFTVEPFSLRALYQK CCEECCCCHHHHHHH	27.88	-
584	Phosphorylation	SHHYRILSSPVSLAR HHCHHHHCCHHHHHH	30.17	23984901
585	Phosphorylation	HHYRILSSPVSLARR HCHHHHCCHHHHHHC	26.35	21149613
588	Phosphorylation	RILSSPVSLARRNSS HHHCCHHHHHHCCCC	21.50	23984901
653	Phosphorylation	GLLQPLGSPNCVKSR CCCCCCCCCCCHHCC	22.18	23984901

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of HUNK_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of HUNK_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of HUNK_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
NEDD4_MOUSE	Nedd4	physical	22745772

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of HUNK_MOUSE

Related Literatures of Post-Translational Modification