HTR5B_HUMAN - dbPTM
HTR5B_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID HTR5B_HUMAN
UniProt AC Q9P2D3
Protein Name HEAT repeat-containing protein 5B
Gene Name HEATR5B
Organism Homo sapiens (Human).
Sequence Length 2071
Subcellular Localization
Protein Description
Protein Sequence MELAHSLLLNEEALAQITEAKRPVFIFEWLRFLDKVLVAANKTDVKEKQKKLVEQLTGLISSSPGPPTRKLLAKNLAALYSIGDTFTVFQTLDKCNDIIRNKDDTAAYLPTKLAAVACVGAFYEKMGRMLGSAFPETVNNLLKSLKSAESQGRSEILMSLQKVLSGLGGAAASSHRDIYKNARSLLTDRSMAVRCAVAKCLLELQNEAVFMWTAELENIATLCFKALENSNYGVRVAVSKLLGTVMATALMPKQATVMRQNVKRATFDEVLELMATGFLRGGSGFLKSGGEMLKVGGSVNREVRVGVTQAYVVFVTTLGGQWLERSFATFLSHVLDLVSHPRATQTHVEAVYSRRCVSFILRATVGSLLGEKAQIAAAKEICQAIGKQMKAVEAVVNDTSGENKSGAADIAASQHVMVCALQELGSLVQSLNATASPLIQEASIGLLEIVTSVLLHPSMAARLAAAWCLRCVAVALPFQLTPFLDRCAERLNNLKTSPEAVSGYSFAMAALLGGVHQCPLGIPHAKGKMVVSIAEDLLRTAAQNSRLSLQRTQAGWLLLGALMTLGPSVVRYHLPKMLLLWRNVFPRSLKELEAEKARGDSFTWQVTLEGRAGALCAMRSFVAHCPELLTEDVIRKLMTPIECAMTMMSHIPSVMKAHGAHLKASAAMVRLRLYDILALLPPKTYEGSFNALLRELVAEFTLTDNSANTTTSLLRSLCHYDDSVLLGSWLQETDHKSIEDQLQPNSASGSGALEHDPSSIYLRIPAGEAVPGPLPLGVSVIDASVALFGVVFPHVSYKHRLQMLDHFAECVKQAKGVRQQAVQLNIFTAVLSALKGLAENKSTLGPEEVRKSALTLVMGPLDNPNPILRCAAGEALGRMAQVVGEATFIARMAQYSFDKLKSARDVVSRTGHSLALGCLHRYVGGIGSGQHLKTSVSILLALAQDGTSPEVQTWSLHSLALIVDSSGPMYRGYVEPTLSLVLTLLLTVPPSHTEVHQCLGRCLGAIITTVGPELQGNGATTSTIRSSCLVGCAITQDHSDSLVQAAAISCLQQLHMFAPRHVNLSSLVPSLCVHLCSSHLLLRRAAVACLRQLAQREAAEVCEYAMSLAKNTGDKESSSANVSPFAPGVSSRTDIHCRHQGVNITETGLEGLLFGMLDRETDRKLCSDIHDTLGHMLSSLAVEKLSHWLMLCKDVLAASSDMSTATLLSSGKDEEAEKKDEMDDDTMFTTLGEEDKSKPFVAPRWATRVFAADCLCRIINLCENADQAHFDLALARSAKLRNPTNDLLVLHLSDLIRMAFMAATDHSNQLRMAGLQALEDIIKKFASVPEPEFPGHVILEQYQANVGAALRPAFSQDTPSDIIAKACQVCSTWIGSGVVSDLNDLRRVHNLLVSSLDKVQAGKGSSSQLYRESATTMEKLAVLKAWAEVYVVAMNIKKEAESKPKRAIKNTDDDDDDCGTIDELPPDSLITLVQPELPTLSRLWLAALKDYALLTLPAEFSSQLPPDGGAFYTPETIDTARLHYRNSWAPILHAVALWLNSTGFTCSESTEAAAISGLQKRSTSVNLNQASGAVGSAKSLPEINKDRMHLILGVSIQFLCSPRPEEPIEHVTACLQALHTLLDSPYARVHIAEDQLIGVELLSVLHRLLLTWNPSSVQLLVTGVVQQIVRAAQDYLQEKRNTLNEDDMEKEACTVLGEGGDSGGLIPGKSLVFATMELLMFILVRHMPHLSTKVSDSPSHIATKTRLSEESARLVAATVTILSDLPSLCSPAGCMTILPTILFLIARILKDTAIKSADNQVPPPVSAALQGIKSIVTLSMAKTEAGVQKQWTALIRSTLACILEYSQPEDSVPTPDEVSMLTAIALFLWSASNEIIGVQSLQNGCMNRFKNALNSCDPWVQAKCYQLLLSVFQHSNRALSTPYIHSLAPIVVEKLKAVERNRPASNIELLAVQEGIKVLETLVALGEEQNRVQLLALLVPTLISYLLDENSFASASSASKDLHEFALQNLMHIGPLYPHAFKTVMGAAPELKVRLETAVRASQASKAKAAARQPAPAIHSAPTIKLKTSFF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
42UbiquitinationKVLVAANKTDVKEKQ
HHHHHCCCCCHHHHH		41.1829967540
146UbiquitinationNNLLKSLKSAESQGR
HHHHHHHHHHHHCCH		55.5029967540
159PhosphorylationGRSEILMSLQKVLSG
CHHHHHHHHHHHHHH		24.97-
165PhosphorylationMSLQKVLSGLGGAAA
HHHHHHHHHCCHHHH		34.65-
189MethylationARSLLTDRSMAVRCA
HHHHHCCHHHHHHHH		24.09115478371
230PhosphorylationCFKALENSNYGVRVA
HHHHHHCCCHHHHHH		23.2725693802
232PhosphorylationKALENSNYGVRVAVS
HHHHCCCHHHHHHHH		19.4725693802
239PhosphorylationYGVRVAVSKLLGTVM
HHHHHHHHHHHHHHH		14.0925693802
244PhosphorylationAVSKLLGTVMATALM
HHHHHHHHHHHHHHC		13.6922210691
248PhosphorylationLLGTVMATALMPKQA
HHHHHHHHHHCCCHH		11.3922210691
266PhosphorylationRQNVKRATFDEVLEL
HHHHHHCCHHHHHHH		35.3330387612
276PhosphorylationEVLELMATGFLRGGS
HHHHHHHHCCCCCCC		17.9430387612
294UbiquitinationKSGGEMLKVGGSVNR
CCCCEEEEECCCCCC		37.21-
372UbiquitinationVGSLLGEKAQIAAAK
HHHHHCHHHHHHHHH		43.74-
387UbiquitinationEICQAIGKQMKAVEA
HHHHHHHHHHHHHHH		40.90-
532PhosphorylationAKGKMVVSIAEDLLR
CCCCEEEHHHHHHHH		12.5027794612
540PhosphorylationIAEDLLRTAAQNSRL
HHHHHHHHHHHCCCH		26.7229449344
545PhosphorylationLRTAAQNSRLSLQRT
HHHHHHCCCHHHHHH		23.6330108239
548PhosphorylationAAQNSRLSLQRTQAG
HHHCCCHHHHHHHHH		22.7330108239
564PhosphorylationLLLGALMTLGPSVVR
HHHHHHHHHCHHHHH		29.43-
568PhosphorylationALMTLGPSVVRYHLP
HHHHHCHHHHHHHHH		31.29-
590UbiquitinationNVFPRSLKELEAEKA
HCCCHHHHHHHHHHH		62.59-
601PhosphorylationAEKARGDSFTWQVTL
HHHHCCCCCEEEEEE		27.65-
620PhosphorylationGALCAMRSFVAHCPE
HHHHHHHHHHHHCHH		15.8123403867
630PhosphorylationAHCPELLTEDVIRKL
HHCHHHCCHHHHHHH		42.6423403867
639PhosphorylationDVIRKLMTPIECAMT
HHHHHHCCHHHHHHH		31.3923403867
656AcetylationSHIPSVMKAHGAHLK
HCCHHHHHHCCCHHH		34.7725953088
663AcetylationKAHGAHLKASAAMVR
HHCCCHHHHHHHHHH		30.3525953088
712PhosphorylationNSANTTTSLLRSLCH
CCCCHHHHHHHHHCC		24.2624719451
828PhosphorylationAVQLNIFTAVLSALK
HHHHHHHHHHHHHHH		16.4420058876
832PhosphorylationNIFTAVLSALKGLAE
HHHHHHHHHHHHHHH		25.5920058876
841UbiquitinationLKGLAENKSTLGPEE
HHHHHHCCCCCCHHH		36.0029967540
842PhosphorylationKGLAENKSTLGPEEV
HHHHHCCCCCCHHHH		40.2120058876
843PhosphorylationGLAENKSTLGPEEVR
HHHHCCCCCCHHHHH		37.0320058876
899UbiquitinationMAQYSFDKLKSARDV
HHHHCHHHHHHHHHH		56.66-
966PhosphorylationLALIVDSSGPMYRGY
EEEEECCCCCCCCCC		42.3125332170
970PhosphorylationVDSSGPMYRGYVEPT
ECCCCCCCCCCCHHH		12.2025332170
1104PhosphorylationEAAEVCEYAMSLAKN
HHHHHHHHHHHHHHH		11.5025147952
1115UbiquitinationLAKNTGDKESSSANV
HHHHCCCCCCCCCCC		61.9229967540
1117PhosphorylationKNTGDKESSSANVSP
HHCCCCCCCCCCCCC		35.0221712546
1119PhosphorylationTGDKESSSANVSPFA
CCCCCCCCCCCCCCC		32.8925627689
1123PhosphorylationESSSANVSPFAPGVS
CCCCCCCCCCCCCCC		17.6925159151
1167PhosphorylationETDRKLCSDIHDTLG
HHCHHHHHHHHHHHH		50.4627732954
1172PhosphorylationLCSDIHDTLGHMLSS
HHHHHHHHHHHHHHH		22.0727732954
1178PhosphorylationDTLGHMLSSLAVEKL
HHHHHHHHHHHHHHH		18.7420873877
1179PhosphorylationTLGHMLSSLAVEKLS
HHHHHHHHHHHHHHH		19.1820873877
1212UbiquitinationATLLSSGKDEEAEKK
HHHHHCCCCHHHHHH		65.0121890473
1324UbiquitinationALEDIIKKFASVPEP
HHHHHHHHHCCCCCC		35.44-
1394PhosphorylationRVHNLLVSSLDKVQA
HHHHHHHHCCCHHHC		25.75-
1403UbiquitinationLDKVQAGKGSSSQLY
CCHHHCCCCCCHHHH		59.6529967540
1405PhosphorylationKVQAGKGSSSQLYRE
HHHCCCCCCHHHHHH		30.24-
1562PhosphorylationISGLQKRSTSVNLNQ
HHCCCCCCCCCCHHH		31.8828450419
1563PhosphorylationSGLQKRSTSVNLNQA
HCCCCCCCCCCHHHC		40.5026657352
1564PhosphorylationGLQKRSTSVNLNQAS
CCCCCCCCCCHHHCC		15.3928450419
1704UbiquitinationGEGGDSGGLIPGKSL
CCCCCCCCCCCCHHH		25.1221890473
1735PhosphorylationPHLSTKVSDSPSHIA
CCCCCCCCCCHHHHH		33.6530266825
1737PhosphorylationLSTKVSDSPSHIATK
CCCCCCCCHHHHHHH		22.3129255136
1739PhosphorylationTKVSDSPSHIATKTR
CCCCCCHHHHHHHHC		31.3230266825
1740UbiquitinationKVSDSPSHIATKTRL
CCCCCHHHHHHHHCC		19.6521890473
1740 (in isoform 3)Ubiquitination-19.6521890473
1743PhosphorylationDSPSHIATKTRLSEE
CCHHHHHHHHCCCHH		32.1423927012
1790AcetylationFLIARILKDTAIKSA
HHHHHHHHHHHHHCC		51.1425953088
1817UbiquitinationQGIKSIVTLSMAKTE
HHHHHHHHHHCCCCC		16.0821890473
1823PhosphorylationVTLSMAKTEAGVQKQ
HHHHCCCCCCCCHHH		22.87-
1829UbiquitinationKTEAGVQKQWTALIR
CCCCCCHHHHHHHHH		45.4522817900
1829 (in isoform 1)Ubiquitination-45.4521890473
2060PhosphorylationQPAPAIHSAPTIKLK
CCCCCCCCCCEEEEE		29.8124732914
2063PhosphorylationPAIHSAPTIKLKTSF
CCCCCCCEEEEECCC		30.3824702127
2067MethylationSAPTIKLKTSFF---
CCCEEEEECCCC---		36.80-
2069PhosphorylationPTIKLKTSFF-----
CEEEEECCCC-----		24.0621712546
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of HTR5B_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of HTR5B_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of HTR5B_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of HTR5B_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of HTR5B_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle.";
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.;
Mol. Cell 31:438-448(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1123 AND SER-1737, ANDMASS SPECTROMETRY.

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