| UniProt ID | HTR12_ARATH | |
|---|---|---|
| UniProt AC | Q8RVQ9 | |
| Protein Name | Histone H3-like centromeric protein HTR12 | |
| Gene Name | HTR12 | |
| Organism | Arabidopsis thaliana (Mouse-ear cress). | |
| Sequence Length | 178 | |
| Subcellular Localization | Chromosome, centromere, kinetochore . Localizes exclusively in the kinetochore domain of centromeres (PubMed:12034896, PubMed:17028205). Localized at centromeres in both mitotic and meiotic cells (PubMed:21695238). | |
| Protein Description | Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division (By similarity).. | |
| Protein Sequence | MARTKHRVTRSQPRNQTDAAGASSSQAAGPTTTPTRRGGEGGDNTQQTNPTTSPATGTRRGAKRSRQAMPRGSQKKSYRYRPGTVALKEIRHFQKQTNLLIPAASFIREVRSITHMLAPPQINRWTAEALVALQEAAEDYLVGLFSDSMLCAIHARRVTLMRKDFELARRLGGKGRPW | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 5 | "N6,N6,N6-trimethyllysine" | ---MARTKHRVTRSQ ---CCCCCCCCCCCC | 24.70 | - | |
| 5 | Methylation | ---MARTKHRVTRSQ ---CCCCCCCCCCCC | 24.70 | - | |
| 11 | Phosphorylation | TKHRVTRSQPRNQTD CCCCCCCCCCCCCCC | 34.86 | - | |
| 17 | Phosphorylation | RSQPRNQTDAAGASS CCCCCCCCCCCCCCC | 31.02 | 30407730 | |
| 23 | Phosphorylation | QTDAAGASSSQAAGP CCCCCCCCCCCCCCC | 29.60 | 25561503 | |
| 24 | Phosphorylation | TDAAGASSSQAAGPT CCCCCCCCCCCCCCC | 26.40 | 25561503 | |
| 25 | Phosphorylation | DAAGASSSQAAGPTT CCCCCCCCCCCCCCC | 22.73 | 25561503 | |
| 31 | Phosphorylation | SSQAAGPTTTPTRRG CCCCCCCCCCCCCCC | 42.24 | 25561503 | |
| 32 | Phosphorylation | SQAAGPTTTPTRRGG CCCCCCCCCCCCCCC | 33.63 | 25561503 | |
| 33 | Phosphorylation | QAAGPTTTPTRRGGE CCCCCCCCCCCCCCC | 25.74 | 19880383 | |
| 35 | Phosphorylation | AGPTTTPTRRGGEGG CCCCCCCCCCCCCCC | 30.79 | 29654922 | |
| 52 | Phosphorylation | TQQTNPTTSPATGTR CCCCCCCCCCCCCCC | 33.69 | 25561503 | |
| 53 | Phosphorylation | QQTNPTTSPATGTRR CCCCCCCCCCCCCCC | 18.27 | 25561503 | |
| 63 | Methylation | TGTRRGAKRSRQAMP CCCCCCCHHHHHCCC | 54.45 | - | |
| 63 | Acetylation | TGTRRGAKRSRQAMP CCCCCCCHHHHHCCC | 54.45 | - | |
| 75 | Methylation | AMPRGSQKKSYRYRP CCCCCCCCCCCCCCC | 45.44 | - | |
| 75 | "N6,N6,N6-trimethyllysine" | AMPRGSQKKSYRYRP CCCCCCCCCCCCCCC | 45.44 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of HTR12_ARATH !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of HTR12_ARATH !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of HTR12_ARATH !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of HTR12_ARATH !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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