HSPB6_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HSPB6_MOUSE
• UniProt AC: Q5EBG6
• Protein Name: Heat shock protein beta-6
• Gene Name: Hspb6
• Organism: Mus musculus (Mouse).
• Sequence Length: 162
• Subcellular Localization: Cytoplasm . Nucleus . Secreted . Translocates to nuclear foci during heat shock.
• Protein Description: Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state. Seems to have versatile functions in various biological processes. Plays a role in regulating muscle function such as smooth muscle vasorelaxation and cardiac myocyte contractility. May regulate myocardial angiogenesis implicating KDR. Overexpression mediates cardioprotection and angiogenesis after induced damage. Stabilizes monomeric YWHAZ thereby supporting YWHAZ chaperone-like activity..
• Protein Sequence: MEIPVPVQPSWLRRASAPLPGFSAPGRLFDQRFGEGLLEAELASLCPAAIAPYYLRAPSVALPTAQVSTDSGYFSVLLDVKHFLPEEISVKVVDDHVEVHARHEERPDEHGFIAREFHRRYRLPPGVDPAAVTSALSPEGVLSIQATPASAQAQLPSPPAAK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
16	Phosphorylation	PSWLRRASAPLPGFS HHHHHHCCCCCCCCC	28.71	26824392
23	Phosphorylation	SAPLPGFSAPGRLFD CCCCCCCCCCCCHHC	39.20	27149854
66	Deamidation	SVALPTAQVSTDSGY CCCCCCCEEECCCCC	31.97	-
150	Phosphorylation	SIQATPASAQAQLPS EEEECCCCHHHCCCC	23.32	26643407
157	Phosphorylation	SAQAQLPSPPAAK-- CHHHCCCCCCCCC--	52.70	26824392

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
16	S	Phosphorylation	Kinase	PKACA	P05132	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
16	S	Phosphorylation	Phosphorylated at Ser-16 by PKA and probably PKD1K; required to protect cardiomyocytes from apoptosis.	21334344

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HSPB6_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of HSPB6_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-16, AND MASSSPECTROMETRY.
PubMed: 19367708