HSP7P_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HSP7P_ARATH
• UniProt AC: F4HQD4
• Protein Name: Heat shock 70 kDa protein 15
• Gene Name: HSP70-15
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 831
• Subcellular Localization: Cytoplasm . Nucleus . Predominantly detected in the cytoplasm.
• Protein Description: In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage (By similarity)..
• Protein Sequence: MSVVGFDFGNENCLVAVARQRGIDVVLNDESNRETPAIVCFGDKQRFIGTAGAASTMMNPKNSISQIKRLIGRQFSDPELQRDIKSLPFSVTEGPDGYPLIHANYLGEIRAFTPTQVMGMMLSNLKGIAEKNLNTAVVDCCIGIPVYFTDLQRRAVLDAATIAGLHPLHLIHETTATALAYGIYKTDLPENDQLNVAFIDIGHASMQVCIAGFKKGQLKILSHAFDRSLGGRDFDEVLFNHFAAKFKDEYKIDVSQNAKASLRLRATCEKLKKVLSANPMAPLNIECLMAEKDVRGVIKREEFEEISIPILERVKRPLEKALSDAGLTVEDVHMVEVVGSGSRVPAMIKILTEFFGKEPRRTMNASECVSRGCALQCAILSPTFKVREFQVHESFPFSISLAWKGAATDAQNGGTENQQSTIVFPKGNPIPSVKALTFYRSGTFSIDVQYSDVNDLQAPPKISTYTIGPFQSSKGERAKLKVKVRLNLHGIVSVESATLLEEEEVEVSVTKDQSEETAKMDTDKASAEAAPASGDSDVNMQDAKDTSDATGTDNGVPESAEKPVQMETDSKAEAPKKKVKKTNVPLSELVYGALKTVEVEKAVEKEFEMALQDRVMEETKDRKNAVESYVYDMRNKLSDKYQEYITDSEREAFLANLQEVEDWLYEDGEDETKGVYVAKLEELKKVGDPVEVRYKESLERGSVIDQLGYCINSYREAAVSNDPKFDHIELAEKQKVLNECVEAEAWLREKQQQQDTLPKYATPALLSADVKSKAEALDKFCRPIMTKPKPAAKAEAPQAKGGEQADEGKSEPEQPASAEAMETENPAEGST

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
123	Phosphorylation	QVMGMMLSNLKGIAE HHHHHHHHCCHHHHH	23.40	19880383
437	Phosphorylation	IPSVKALTFYRSGTF CCCEEEEEEEECCEE	24.39	29654922
526	Phosphorylation	KMDTDKASAEAAPAS CCCCCHHHHHCCCCC	32.17	23776212
533	Phosphorylation	SAEAAPASGDSDVNM HHHCCCCCCCCCCCH	41.91	23776212
536	Phosphorylation	AAPASGDSDVNMQDA CCCCCCCCCCCHHHH	47.16	30291188
648	Phosphorylation	YQEYITDSEREAFLA HHHHCCHHHHHHHHH	29.88	19880383
810	Phosphorylation	EQADEGKSEPEQPAS CCCCCCCCCCCCCCC	70.05	23776212
817	Phosphorylation	SEPEQPASAEAMETE CCCCCCCCHHHHHCC	33.07	23776212
823	Phosphorylation	ASAEAMETENPAEGS CCHHHHHCCCCCCCC	28.16	23776212
830	Phosphorylation	TENPAEGST------ CCCCCCCCC------	23.58	23776212
831	Phosphorylation	ENPAEGST------- CCCCCCCC-------	54.19	23776212

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HSP7P_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HSP7P_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HSP7P_ARATH !!

Protein-Protein Interaction

Oops, there are no PPI records of HSP7P_ARATH !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.