HSP7O_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HSP7O_ARATH
• UniProt AC: Q9S7C0
• Protein Name: Heat shock 70 kDa protein 14
• Gene Name: HSP70-14
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 831
• Subcellular Localization: Cytoplasm . Nucleus . Predominantly detected in the cytoplasm.
• Protein Description: In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage (By similarity)..
• Protein Sequence: MSVVGFDFGNENCLVAVARQRGIDVVLNDESNRETPAIVCFGDKQRFIGTAGAASTMMNPKNSISQIKRLIGRQFSDPELQRDIKSLPFSVTEGPDGYPLIHANYLGEKRAFTPTQVMGMMLSNLKGIAEKNLNTAVVDCCIGIPVYFTDLQRRAVLDAATIAGLHPLRLIHETTATALAYGIYKTDLPESDQLNVAFIDIGHASMQVCIAGFKKGQLKILSHAFDRSLGGRDFDEVLFNHFAAKFKDEYKIDVSQNAKASLRLRATCEKLKKVLSANPLAPLNIECLMDEKDVRGVIKREEFEEISIPILERVKRPLEKALSDAGLTVEDVHMVEVIGSGSRVPAMIKILTEFFGKEPRRTMNASECVSRGCALQCAILSPTFKVREFQVHESFPFSISLAWKGAASEAQNGGAENQQSTIVFPKGNPIPSVKALTFYRSGTFSVDVQYSDVNDLQAPPKISTYTIGPFQSSKGERAKLKVKVRLNLHGIVSVESATLLEEEEVEVPVTKEHSEETTKMDSDKASAEAAPASGDCDVNMQDAKDTSDATGTDNGVPESAEKPVQMETDSKAEAPKKKVKKTNVPLSELVYGALKTVEVEKAVEKEFEMALQDRVMEETKDRKNAVESYVYDMRNKLSDKYQEYITDSEREAFLANLQEVEDWLYEDGEDETKGVYVAKLEELKKVGDPVEVRYKESLERGSVIDQLGYCINSYREAAMSTDPKFDHIELAEKQKVLNECVEAEAWLRGKQQQQDTLPKYATPALLSADVKSKAEALDKFCRPIMTKPKPVAKAEAPQAKGGEQADEGKSEPEQPASAEPMETENPAEGST

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
57	Sulfoxidation	TAGAASTMMNPKNSI CCCCHHHHCCCCCHH	1.95	25693801
58	Sulfoxidation	AGAASTMMNPKNSIS CCCHHHHCCCCCHHH	8.65	25693801
123	Phosphorylation	QVMGMMLSNLKGIAE HHHHHHHHCCHHHHH	23.40	19880383
437	Phosphorylation	IPSVKALTFYRSGTF CCCEEEEEEECCCEE	24.39	29654922
533	Phosphorylation	SAEAAPASGDCDVNM HHHCCCCCCCCCCCC	33.82	-
566	Sulfoxidation	SAEKPVQMETDSKAE CCCCCCCCCCCCCCC	6.44	23289948
633	Sulfoxidation	VESYVYDMRNKLSDK HHHHHHHHHHHHCHH	2.52	25693801
648	Phosphorylation	YQEYITDSEREAFLA HHHHCCHHHHHHHHH	29.88	19880383
830	Phosphorylation	TENPAEGST------ CCCCCCCCC------	23.58	29654922
831	Phosphorylation	ENPAEGST------- CCCCCCCC-------	54.19	29654922

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HSP7O_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HSP7O_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HSP7O_ARATH !!

Protein-Protein Interaction

Oops, there are no PPI records of HSP7O_ARATH !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.