dbPTM

HSD1A_ARATH - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	HSD1A_ARATH
UniProt AC	P0DKC5
Protein Name	11-beta-hydroxysteroid dehydrogenase 1A
Gene Name	HSD1
Organism	Arabidopsis thaliana (Mouse-ear cress).
Sequence Length	349
Subcellular Localization	Lipid droplet. Membrane Single-pass type II membrane protein.
Protein Description	Catalyzes 11-beta, 17-beta-hydroxysteroid and reduces 17-beta-ketosteroids. Involved in regulating plant growth and development, probably promoting or mediating brassinosteroid effects. Plays a role during seed maturation..
Protein Sequence	MELINDFLNLTAPFFTFFGLCFFLPPFYFFKFLQSIFSTIFSENLYGKVVLITGASSGIGEQLAYEYACRGACLALTARRKNRLEEVAEIARELGSPNVVTVHADVSKPDDCRRIVDDTITHFGRLDHLVNNAGMTQISMFENIEDITRTKAVLDTNFWGSVYTTRAALPYLRQSNGKIVAMSSSAAWLTAPRMSFYNASKAALLSFFETMRIELGGDVHITIVTPGYIESELTQGKYFSGEGELIVNQDMRDVQVGPFPVASASGCAKSIVNGVCRKQRYVTEPSWFKVTYLWKVLCPELIEWGCRLLYMTGTGMSEDTALNKRIMDIPGVRSTLYPESIRTPEIKSD

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	Reference
96	Phosphorylation	EIARELGSPNVVTVH HHHHHHCCCCEEEEE	19880383
148	Phosphorylation	FENIEDITRTKAVLD CCCHHHHHHCCEEEE	27288362
240	Phosphorylation	LTQGKYFSGEGELIV ECCCCCCCCCCEEEE	27288362
334	Phosphorylation	MDIPGVRSTLYPESI HCCCCCHHCCCCHHC	27288362
335	Phosphorylation	DIPGVRSTLYPESIR CCCCCHHCCCCHHCC	27288362
337	Phosphorylation	PGVRSTLYPESIRTP CCCHHCCCCHHCCCC	27288362
340	Phosphorylation	RSTLYPESIRTPEIK HHCCCCHHCCCCCCC	27288362
343	Phosphorylation	LYPESIRTPEIKSD- CCCHHCCCCCCCCC-	27288362
348	Phosphorylation	IRTPEIKSD------ CCCCCCCCC------	19880383

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of HSD1A_ARATH !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of HSD1A_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of HSD1A_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of HSD1A_ARATH !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of HSD1A_ARATH

Related Literatures of Post-Translational Modification