HS3SB_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HS3SB_HUMAN
• UniProt AC: Q9Y662
• Protein Name: Heparan sulfate glucosamine 3-O-sulfotransferase 3B1
• Gene Name: HS3ST3B1
• Organism: Homo sapiens (Human).
• Sequence Length: 390
• Subcellular Localization: Golgi apparatus membrane ; Single-pass type II membrane protein .
• Protein Description: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in IdoUA2S-GlcNS and also in IdoUA2S-GlcNH2. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its entry. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate..
• Protein Sequence: MGQRLSGGRSCLDVPGRLLPQPPPPPPPVRRKLALLFAMLCVWLYMFLYSCAGSCAAAPGLLLLGSGSRAAHDPPALATAPDGTPPRLPFRAPPATPLASGKEMAEGAASPEEQSPEVPDSPSPISSFFSGSGSKQLPQAIIIGVKKGGTRALLEFLRVHPDVRAVGAEPHFFDRSYDKGLAWYRDLMPRTLDGQITMEKTPSYFVTREAPARISAMSKDTKLIVVVRDPVTRAISDYTQTLSKRPDIPTFESLTFKNRTAGLIDTSWSAIQIGIYAKHLEHWLRHFPIRQMLFVSGERLISDPAGELGRVQDFLGLKRIITDKHFYFNKTKGFPCLKKAEGSSRPHCLGKTKGRTHPEIDREVVRRLREFYRPFNLKFYQMTGHDFGWD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MGQRLSGGRSCLD --CCCCCCCCCCCCC	41.20	29083192
10	Phosphorylation	QRLSGGRSCLDVPGR CCCCCCCCCCCCCCC	23.47	29083192
79	O-linked_Glycosylation	HDPPALATAPDGTPP CCCCCCCCCCCCCCC	39.30	55831641
84	O-linked_Glycosylation	LATAPDGTPPRLPFR CCCCCCCCCCCCCCC	37.18	55831647
96	O-linked_Glycosylation	PFRAPPATPLASGKE CCCCCCCCCCCCCHH	25.30	OGP
132	Phosphorylation	ISSFFSGSGSKQLPQ CHHHCCCCCCCCCCE	38.40	-
134	Phosphorylation	SFFSGSGSKQLPQAI HHCCCCCCCCCCEEE	20.94	-
191	Phosphorylation	YRDLMPRTLDGQITM HHHHCCCCCCCCEEE	24.27	27251275
197	Phosphorylation	RTLDGQITMEKTPSY CCCCCCEEEEECCCC	16.05	27251275
200	Acetylation	DGQITMEKTPSYFVT CCCEEEEECCCCEEE	55.72	30589383
201	Phosphorylation	GQITMEKTPSYFVTR CCEEEEECCCCEEEC	12.26	27251275
203	Phosphorylation	ITMEKTPSYFVTREA EEEEECCCCEEECCC	36.11	29116813
207	Phosphorylation	KTPSYFVTREAPARI ECCCCEEECCCCHHH	16.94	29116813
232	Phosphorylation	VVVRDPVTRAISDYT EEECCHHHHHHHHHH	21.55	24670416
258	N-linked_Glycosylation	FESLTFKNRTAGLID CCCCCCCCCCCCCEE	42.20	UniProtKB CARBOHYD
266	Phosphorylation	RTAGLIDTSWSAIQI CCCCCEECCCHHHHH	25.71	28387310
267	Phosphorylation	TAGLIDTSWSAIQIG CCCCEECCCHHHHHH	18.45	28387310
269	Phosphorylation	GLIDTSWSAIQIGIY CCEECCCHHHHHHHH	18.43	22468782
276	Phosphorylation	SAIQIGIYAKHLEHW HHHHHHHHHHHHHHH	12.37	22468782
324	Acetylation	LKRIITDKHFYFNKT CCEEEECCCCCCCCC	27.28	7365175
329	N-linked_Glycosylation	TDKHFYFNKTKGFPC ECCCCCCCCCCCCCC	39.44	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HS3SB_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HS3SB_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HS3SB_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of HS3SB_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.