HS3SA_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HS3SA_HUMAN
• UniProt AC: Q9Y663
• Protein Name: Heparan sulfate glucosamine 3-O-sulfotransferase 3A1
• Gene Name: HS3ST3A1
• Organism: Homo sapiens (Human).
• Sequence Length: 406
• Subcellular Localization: Golgi apparatus membrane ; Single-pass type II membrane protein .
• Protein Description: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in IdoUA2S-GlcNS and also in IdoUA2S-GlcNH2. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its entry. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate..
• Protein Sequence: MAPPGPASALSTSAEPLSRSIFRKFLLMLCSLLTSLYVFYCLAERCQTLSGPVVGLSGGGEEAGAPGGGVLAGGPRELAVWPAAAQRKRLLQLPQWRRRRPPAPRDDGEEAAWEEESPGLSGGPGGSGAGSTVAEAPPGTLALLLDEGSKQLPQAIIIGVKKGGTRALLEFLRVHPDVRAVGAEPHFFDRSYDKGLAWYRDLMPRTLDGQITMEKTPSYFVTREAPARISAMSKDTKLIVVVRDPVTRAISDYTQTLSKRPDIPTFESLTFKNRTAGLIDTSWSAIQIGIYAKHLEHWLRHFPIRQMLFVSGERLISDPAGELGRVQDFLGLKRIITDKHFYFNKTKGFPCLKKAEGSSRPHCLGKTKGRTHPEIDREVVRRLREFYRPFNLKFYQMTGHDFGWDG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
40	Phosphorylation	LTSLYVFYCLAERCQ HHHHHHHHHHHHHHH	4.05	-
127	Phosphorylation	LSGGPGGSGAGSTVA CCCCCCCCCCCCCCC	31.24	28787133
140	Phosphorylation	VAEAPPGTLALLLDE CCCCCCCCEEEEECC	18.03	28787133
206	Phosphorylation	YRDLMPRTLDGQITM HHHHCCCCCCCCEEE	24.27	27251275
212	Phosphorylation	RTLDGQITMEKTPSY CCCCCCEEEEECCCC	16.05	27251275
215	Acetylation	DGQITMEKTPSYFVT CCCEEEEECCCCEEE	55.72	30589377
216	Phosphorylation	GQITMEKTPSYFVTR CCEEEEECCCCEEEC	12.26	27251275
218	Phosphorylation	ITMEKTPSYFVTREA EEEEECCCCEEECCC	36.11	29116813
222	Phosphorylation	KTPSYFVTREAPARI ECCCCEEECCCCHHH	16.94	29116813
222	O-linked_Glycosylation	KTPSYFVTREAPARI ECCCCEEECCCCHHH	16.94	OGP
247	Phosphorylation	VVVRDPVTRAISDYT EEECCHHHHHHHHHH	21.55	24670416
273	N-linked_Glycosylation	FESLTFKNRTAGLID CCCCCCCCCCCCCEE	42.20	UniProtKB CARBOHYD
281	Phosphorylation	RTAGLIDTSWSAIQI CCCCCEECCCHHHHH	25.71	28387310
282	Phosphorylation	TAGLIDTSWSAIQIG CCCCEECCCHHHHHH	18.45	28387310
284	Phosphorylation	GLIDTSWSAIQIGIY CCEECCCHHHHHHHH	18.43	22468782
291	Phosphorylation	SAIQIGIYAKHLEHW HHHHHHHHHHHHHHH	12.37	22468782
339	Acetylation	LKRIITDKHFYFNKT CCEEEECCCCCCCCC	27.28	7365187
344	N-linked_Glycosylation	TDKHFYFNKTKGFPC ECCCCCCCCCCCCCC	39.44	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HS3SA_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HS3SA_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HS3SA_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of HS3SA_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.