HRH3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HRH3_HUMAN
• UniProt AC: Q9Y5N1
• Protein Name: Histamine H3 receptor
• Gene Name: HRH3
• Organism: Homo sapiens (Human).
• Sequence Length: 445
• Subcellular Localization: Cell membrane; Multi-pass membrane protein.
• Protein Description: The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist). Agonist stimulation of isoform 3 neither modified adenylate cyclase activity nor induced intracellular calcium mobilization..
• Protein Sequence: MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAAGPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSVASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLLCPQKLKIQPHSSLEHCWK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	N-linked_Glycosylation	APPDGPLNASGALAG CCCCCCCCCCHHHHH	34.88	UniProtKB CARBOHYD
275	Phosphorylation	EAMPLHRYGVGEAAV CCCCCHHCCCCCHHH	12.86	30576142
304	Phosphorylation	GGSVASPTSSSGSSS CCCCCCCCCCCCCCC	38.45	30576142
305	Phosphorylation	GSVASPTSSSGSSSR CCCCCCCCCCCCCCC	26.37	30576142
306	Phosphorylation	SVASPTSSSGSSSRG CCCCCCCCCCCCCCC	40.99	30576142
307	Phosphorylation	VASPTSSSGSSSRGT CCCCCCCCCCCCCCC	42.32	30576142
311	Phosphorylation	TSSSGSSSRGTERPR CCCCCCCCCCCCCCC	36.10	30576142
439	Phosphorylation	LKIQPHSSLEHCWK- CCCCCCCCCHHHCC-	34.44	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HRH3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HRH3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HRH3_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of HRH3_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.