HRH1_HUMAN - dbPTM
HRH1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID HRH1_HUMAN
UniProt AC P35367
Protein Name Histamine H1 receptor
Gene Name HRH1
Organism Homo sapiens (Human).
Sequence Length 487
Subcellular Localization Cell membrane
Multi-pass membrane protein .
Protein Description In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system..
Protein Sequence MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLRPENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKLYCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSRTDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRILHIRS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSLPNSSCL
------CCCCCCCCC		53.1630619164
5N-linked_Glycosylation---MSLPNSSCLLED
---CCCCCCCCCCCC		52.42UniProtKB CARBOHYD
6Phosphorylation--MSLPNSSCLLEDK
--CCCCCCCCCCCCC		22.0830619164
7Phosphorylation-MSLPNSSCLLEDKM
-CCCCCCCCCCCCCC		18.5430619164
18N-linked_GlycosylationEDKMCEGNKTTMASP
CCCCCCCCCCCCCCC		19.06UniProtKB CARBOHYD
68PhosphorylationVGNLYIVSLSVADLI
CCCEEEEEHHHHHHH		12.84-
70PhosphorylationNLYIVSLSVADLIVG
CEEEEEHHHHHHHHH		14.04-
94PhosphorylationYLLMSKWSLGRPLCL
HHHHHHCCCCCCHHH		25.3624719451
135PhosphorylationSVQQPLRYLKYRTKT
CHHHHHHHHHHCCCC		18.4126074081
138PhosphorylationQPLRYLKYRTKTRAS
HHHHHHHHCCCCCHH		22.4126074081
140PhosphorylationLRYLKYRTKTRASAT
HHHHHHCCCCCHHHH		33.4115328002
142PhosphorylationYLKYRTKTRASATIL
HHHHCCCCCHHHHHH		30.7515328002
230PhosphorylationHRELINRSLPSFSEI
HHHHHHCCCCCHHHC		39.8930266825
233PhosphorylationLINRSLPSFSEIKLR
HHHCCCCCHHHCCCC		46.8530266825
235PhosphorylationNRSLPSFSEIKLRPE
HCCCCCHHHCCCCCC		42.6330266825
238UbiquitinationLPSFSEIKLRPENPK
CCCHHHCCCCCCCCC		34.1023000965
255PhosphorylationAKKPGKESPWEVLKR
CCCCCCCCHHHHHCC		38.5125159151
261UbiquitinationESPWEVLKRKPKDAG
CCHHHHHCCCCCCCC		64.6523000965
263UbiquitinationPWEVLKRKPKDAGGG
HHHHHCCCCCCCCCC		55.6323000965
265UbiquitinationEVLKRKPKDAGGGSV
HHHCCCCCCCCCCCC		64.3423000965
271PhosphorylationPKDAGGGSVLKSPSQ
CCCCCCCCCCCCCCC		27.7930266825
275PhosphorylationGGGSVLKSPSQTPKE
CCCCCCCCCCCCCCC		26.1430266825
277PhosphorylationGSVLKSPSQTPKEMK
CCCCCCCCCCCCCCC		54.5030266825
279PhosphorylationVLKSPSQTPKEMKSP
CCCCCCCCCCCCCCC		40.4430266825
284UbiquitinationSQTPKEMKSPVVFSQ
CCCCCCCCCCEEECC		53.3429967540
285PhosphorylationQTPKEMKSPVVFSQE
CCCCCCCCCEEECCC		22.9329666759
290PhosphorylationMKSPVVFSQEDDREV
CCCCEEECCCCCCCC		22.5030266825
301PhosphorylationDREVDKLYCFPLDIV
CCCCCEEEEEEHHHH		9.5927259358
321PhosphorylationAEGSSRDYVAVNRSH
HCCCCCCEEEEECCC		6.8122817900
327PhosphorylationDYVAVNRSHGQLKTD
CEEEEECCCCCCCCC		27.1127642862
344PhosphorylationGLNTHGASEISEDQM
CCCCCCCCCCCCCCC		39.80-
347PhosphorylationTHGASEISEDQMLGD
CCCCCCCCCCCCCCC		30.94-
361PhosphorylationDSQSFSRTDSDTTTE
CCCCCCCCCCCCCCC		38.3629255136
363PhosphorylationQSFSRTDSDTTTETA
CCCCCCCCCCCCCCC		35.9229255136
365PhosphorylationFSRTDSDTTTETAPG
CCCCCCCCCCCCCCC		39.3029255136
366PhosphorylationSRTDSDTTTETAPGK
CCCCCCCCCCCCCCC		27.8529255136
367PhosphorylationRTDSDTTTETAPGKG
CCCCCCCCCCCCCCC		33.1725072903
369PhosphorylationDSDTTTETAPGKGKL
CCCCCCCCCCCCCCC		35.7425072903
378PhosphorylationPGKGKLRSGSNTGLD
CCCCCCCCCCCCCCC		57.9423927012
380PhosphorylationKGKLRSGSNTGLDYI
CCCCCCCCCCCCCHH		32.2528355574
382PhosphorylationKLRSGSNTGLDYIKF
CCCCCCCCCCCHHHH		40.6023403867
386PhosphorylationGSNTGLDYIKFTWKR
CCCCCCCHHHHHHHH		15.8525884760
396PhosphorylationFTWKRLRSHSRQYVS
HHHHHHHHHCHHHHC		30.3315328002
398PhosphorylationWKRLRSHSRQYVSGL
HHHHHHHCHHHHCCC		23.4810101032
401PhosphorylationLRSHSRQYVSGLHMN
HHHHCHHHHCCCCCC		8.7528674419
478PhosphorylationCNENFKKTFKRILHI
CCHHHHHHHHHHHHC		34.6722817900
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
140TPhosphorylationKinaseKCC2AQ9UQM7
PhosphoELM
142TPhosphorylationKinaseKCC2AQ9UQM7
PhosphoELM
396SPhosphorylationKinaseKCC2AQ9UQM7
PhosphoELM
396SPhosphorylationKinasePRKG1Q13976
GPS
396SPhosphorylationKinasePRKCAP17252
GPS
396SPhosphorylationKinasePKC-FAMILY-GPS
398SPhosphorylationKinaseARBK1P25098
PhosphoELM
398SPhosphorylationKinasePRKACAP17612
GPS
398SPhosphorylationKinaseKCC2AQ9UQM7
PhosphoELM
398SPhosphorylationKinasePRKG1Q13976
GPS
398SPhosphorylationKinasePRKCAP17252
GPS
398SPhosphorylationKinasePKCAP05696
PSP
398SPhosphorylationKinasePKA-FAMILY-GPS
398SPhosphorylationKinasePKC-FAMILY-GPS
398SPhosphorylationKinasePKA_GROUP-PhosphoELM
478TPhosphorylationKinasePRKCAP17252
GPS
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of HRH1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of HRH1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of HRH1_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
D00234 Astemizole (JAN/USP/INN); Hismanal (TN)
D00270 Chlorpromazine (USP/INN); Thorazine (TN)
D00300 Diphenhydramine (JP16/INN); Restamin (TN)
D00364 Loratadine (JAN/USAN/INN); Claritin (TN)
D00454 Olanzapine (JAN/USAN/INN); Zyprexa (TN)
D00458 Quetiapine fumarate (JP16/USAN); Seroquel (TN)
D00480 Promethazine hydrochloride (JP16/USP); Phenergan (TN); Promethegan (TN)
D00494 Promethazine (JAN/INN)
D00520 Dimenhydrinate (JP16/USP/INN); Dramamine (TN)
D00521 Terfenadine (JAN/USAN/INN); Seldane (TN)
D00659 Azelastine hydrochloride (JP16/USAN); Astelin (TN)
D00662 Azatadine maleate (USP); Optimine (TN)
D00663 Brompheniramine maleate (USAN); Dimetane (TN)
D00664 Cetirizine hydrochloride (JP16/USAN); Zyrtec (TN)
D00665 Chlorpheniramine maleate (JP16/USP); Chlor-trimeton (TN); Teldrin (TN)
D00666 Clemastine fumarate (JP16/USP); Tavist (TN)
D00668 d-Chlorpheniramine maleate (JP16); Dexchlorpheniramine maleate (USP); Mylaramine (TN); Polaramine (T
D00669 Diphenhydramine hydrochloride (JP16/USP); Benadryl (TN)
D00671 Fexofenadine hydrochloride (JP16/USAN); Allegra (TN)
D00672 Hydroxyzine hydrochloride (JP16/USP); Atarax (TN); Vistaril (TN)
D00789 Chlorpromazine hydrochloride (JP16/USP); Sonazine (TN)
D01096 Hydroxyzine pamoate (JP16/USP); Atarax-P (TN); Vistaril pamoate (TN)
D01117 Mizolastine (JAN/INN); Mizollen (TN)
D01143 Isothipendyl hydrochloride (JAN); Andantol (TN)
D01172 Diphenylpyraline hydrochloride (JAN); Hispril (TN); Vena (TN)
D01174 Pheniramine maleate (JAN/USP)
D01192 Olopatadine hydrochloride (JAN/USAN); Allelock (TN); Patanol (TN)
D01242 Promethazine teoclate (JAN/INN); Avomine (TN)
D01295 Cinnarizine (JAN/USAN/INN)
D01317 Meclizine hydrochloride (JAN/USP); Meclizine dihydrochloride monohydrate; Antivert (TN)
D01324 Mequitazine (JP16/INN); Kitazemin (TN)
D01332 Ketotifen fumarate (JP16/USAN); Zaditen (TN)
D01336 Carbinoxamine maleate (JAN/USP); Clistin (TN); Karbinal er (TN)
D01343 Dimetindene maleate (JAN); Dimethindene maleate (USAN); Forhistal maleate (TN)
D01460 Homochlorcyclizine hydrochloride (JP16); Homochlorcyclizine dihydrochloride; SA 97 dihydrochloride;
D01477 Opipramol hydrochloride (JAN/USAN); Insidon (TN)
D01478 Ebastine (JP16/USAN/INN); Kestine (TN)
D01592 Betahistine mesilate (JP16); Suzutolon (TN)
D01627 Diphenylpyraline teoclate (JAN); Piprinhydrinate; Plokon (TN)
D01654 Bepotastine besilate (JAN); Bepotastine besylate (USAN); Bepreve (TN); Talion (TN)
D01713 Epinastine hydrochloride (JAN); Alesion (TN); Elestat (TN)
D01717 Levocabastine hydrochloride (JAN/USAN); Livostin (TN)
D01773 Oxatomide (JAN/USAN/INN); Celtect (TN)
D01782 Triprolidine hydrochloride hydrate (JAN); Triprolidine hydrochloride (USP); Venen (TN)
D01801 Thonzylamine hydrochloride (JAN/USAN); Super anahist (TN)
D01902 Dimetotiazine mesilate (JAN); Fonazine mesylate (USAN); Banistyl (TN)
D02090 Cyclizine lactate (BAN); Marezine (TN)
D02091 Tripelennamine hydrochloride (USP); PBZ-SR (TN)
D02148 Phenindamine tartrate (USAN); Nolahist (TN)
D02234 Cyproheptadine hydrochloride (JP16/USP); Periactin (TN)
D02245 Alimemazine tartrate (JP16); Trimeprazine tartrate (USP); Alimezine (TN)
D02249 Emedastine difumarate (JP16/USP); Daren (TN); Emadine (TN)
D02327 Doxylamine succinate (USP); Decapryn (TN)
D02363 Ketanserin (USAN/INN)
D02419 Diphenhydramine salicylate (JAN)
D02760 Acrivastine (USAN/INN)
D02950 Antazoline phosphate (USP)
D03102 Betahistine hydrochloride (USP); Serc (TN)
D03166 Bromodiphenhydramine hydrochloride (USP); Bromazine hydrochloride; Bromanyl (TN)
D03274 Chlorpromazine hibenzate (JAN); Contomin (TN)
D03285 Diphenhydramine tannate (JP16); Restamin A (TN)
D03290 Promethazine methylenedisalicylate (JAN); Pyrethia (TN)
D03360 Diphenhydramine laurylsulfate (JAN); Vena (TN)
D03475 Chlorpheniramine polistirex (USAN)
D03535 Clemastine (USAN)
D03621 Cyclizine (INN)
D03622 Cyclizine hydrochloride (USP)
D03693 Desloratadine (USAN/INN); Clarinex (TN)
D03704 Dexbrompheniramine maleate (USAN); Disomer (TN)
D03854 Diphenhydramine citrate (USP)
D04034 Chlorpromazine phenolphthalinate (JAN); Wintermin (TN)
D04494 Icotidine (USAN)
D05196 Noberastine (USAN/INN)
D05660 Pyrilamine maleate (USP); Pymafed (TN)
D05742 Rocastine hydrochloride (USAN)
D06021 Tecastemizole (USAN/INN)
D06063 Temelastine (USAN/INN)
D06246 Tripelennamine citrate; PBZ (TN)
D06552 Alcaftadine (USAN/INN); Lastacaft (TN)
D06623 Olanzapine pamoate (USAN); Olanzapine pamoate monohydrate
D07125 Alimemazine (INN); Trimeprazine (BAN); Repeltin (TN)
D07197 Bamipine (INN)
D07198 Chlorphenoxamine (INN)
D07398 Chlorphenamine (INN); Chlorpheniramine; Clofeniramina (TN)
D07402 Levocetirizine (USAN/INN); Xazal (TN)
D07406 Pimethixene (INN); Calmixene (TN)
D07407 Rupatadine (INN)
D07458 Antazoline (INN)
D07459 Antazoline hydrochloride; Phenazolinum (TN)
D07482 Azatadine (INN)
D07483 Azelastine (INN); Optivar (TN)
D07492 Bamipine dihydrochloride; Soventol (TN)
D07493 Bamipine lactate; Soventol (TN)
D07522 Betahistine (INN); Vestibo (TN)
D07543 Brompheniramine (INN); Brotane (TN)
D07617 Carbinoxamine (INN)
D07662 Cetirizine (INN); Cetiderm (TN)
D07684 Chlorphenoxamine hydrochloride; Allergex (TN)
D07734 Cinnarizine dihydrochloride; Celenid (TN)
D07765 Cyproheptadine (INN); Ciprovit (TN)
D07803 Dexchlorpheniramine (INN); d-Chloropheniramine; Dapriton (TN)
D07853 Dimetindene (INN); Dimethindene
D07854 Dimetotiazine (INN); Fonazine; Migristene (TN)
D07860 Dioxopromethazine hydrochloride; Prothanon gel (TN)
D07862 Diphenylpyraline (INN)
D07878 Doxylamine (INN)
D07890 Emedastine (INN); Emadine (TN)
D07900 Epinastine (INN); Purivist (TN)
D07958 Fexofenadine (INN); Telfast (TN)
D08040 Histamine (DCF); Histaminum (TN)
D08041 Homochlorcyclizine (INN)
D08054 Hydroxyzine (INN); Marex (TN)
D08091 Isothipendyl (INN); Actapront (TN)
D08099 Ketanserin tartrate; Sufrexal (TN)
D08105 Ketotifen (INN); Alaway (TN)
D08117 Levocabastine (INN); Livostin (TN)
D08118 Levocetirizine hydrochloride (JAN/USAN); Levocetirizine dihydrochloride; Xyzal (TN)
D08163 Meclozine (BAN); Meclizine; Nevidoxine (TN)
D08183 Mepyramine (INN)
D08184 Mepyramine theophyllineacetate; Fluidasa (TN)
D08293 Olopatadine (INN); Opatanol (TN)
D08297 Opipramol (INN); Opipramol dura (TN)
D08353 Phenindamine (INN)
D08355 Pheniramine (INN)
D08432 Promethazine maleate; Romergan (TN)
D08456 Quetiapine (INN); Norsic (TN)
D08497 Rupatadine fumarate; Rinialer (TN)
D08587 Thonzylamine (INN); Tonamil (TN)
D08645 Tripelennamine (INN)
D08648 Triprolidine (INN)
D08768 Promethazine hibenzate; Hiberna (TN)
D09570 Bilastine (INN)
D09705 Bepotastine (USAN/INN)
D09808 Carbinoxamine diphenyldisulfonate (JAN)
D09819 Chlorpromazine tannate (JAN)
D09918 Latrepirdine dihydrochloride (USAN); Dimebolin; Dimebon
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of HRH1_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-275 AND THR-279, ANDMASS SPECTROMETRY.
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle.";
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.;
Mol. Cell 31:438-448(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-255 AND SER-275, ANDMASS SPECTROMETRY.

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