dbPTM

HORM1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	HORM1_MOUSE
UniProt AC	Q9D5T7
Protein Name	HORMA domain-containing protein 1 {ECO:0000312\|MGI:MGI:1915231}
Gene Name	Hormad1 {ECO:0000312\|MGI:MGI:1915231}
Organism	Mus musculus (Mouse).
Sequence Length	392
Subcellular Localization	Isoform 1: Nucleus . Chromosome . Preferentially localizes to unsynapsed or desynapsed chromosomal regions during the prophase I stage of meiosis (PubMed:19851446, PubMed:19686734, PubMed:27723721). Accumulates on the chromosomes during the leptotene
Protein Description	Plays a key role in meiotic progression. [PubMed: 19686734]
Protein Sequence	MATMQLQRTASLSALVFPNKISTEHQSLMFVKRLLAVSVSCITYLRGIFPERAYGTRYLDDLCVKILKEDKNCPGSSQLVKWMLGCYDALQKKYLRMIILAVYTNPGDPQTISECYQFKFKYTKNGPIMDFISKNQNNKSSTTSADTKKASILLIRKIYVLMQNLGPLPNDVCLTMKLFYYDEVTPPDYQPPGFKDGDCEGVIFDGDPTYLNVGEVPTPFHTFRLKVTTEKERMENIDSTILKPKESKTQFEKILMDKDDVEDENHNNFDIKTKMNEQNENSGASEIKEPNLDCKEEETMQFKKSQSPSISHCQVEQLVSKTSELDVSESKTRSGKIFQSKMVNGNNQQGQTSKENRKRSLRQFRKTVLHVLESSQESVLKKRRVSEPKEHT

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	ATMQLQRTASLSALV CCHHHHHHHHHHHHC	13.98	25293948
11	Phosphorylation	MQLQRTASLSALVFP HHHHHHHHHHHHCCC	23.42	19060867
13	Phosphorylation	LQRTASLSALVFPNK HHHHHHHHHHCCCCC	19.63	25293948
305	Phosphorylation	ETMQFKKSQSPSISH HHHHHCCCCCCCCCH	36.16	22817900
307	Phosphorylation	MQFKKSQSPSISHCQ HHHCCCCCCCCCHHH	27.92	22817900
309	Phosphorylation	FKKSQSPSISHCQVE HCCCCCCCCCHHHHH	41.80	22817900
374	Phosphorylation	TVLHVLESSQESVLK HHHHHHHHCHHHHHH	32.91	22817900
375	Phosphorylation	VLHVLESSQESVLKK HHHHHHHCHHHHHHH	28.70	16141072
378	Phosphorylation	VLESSQESVLKKRRV HHHHCHHHHHHHHCC	25.72	22817900
386	Phosphorylation	VLKKRRVSEPKEHT- HHHHHCCCCCCCCC-	46.50	21454597

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of HORM1_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
375	S	Phosphorylation		21183079
Phosphorylated at Ser-375 in a SPO11-dependent manner.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of HORM1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of HORM1_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of HORM1_MOUSE

Related Literatures of Post-Translational Modification