HOME2_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HOME2_RAT
• UniProt AC: O88801
• Protein Name: Homer protein homolog 2 {ECO:0000305}
• Gene Name: Homer2 {ECO:0000312|RGD:620705}
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 354
• Subcellular Localization: Cytoplasm . Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse. Cell projection, stereocilium . Postsynaptic density of neuronal cells. The stabilization and clustering of the metabotropic glutamate recep
• Protein Description: Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses. Required for normal hearing (By similarity). Negatively regulates T cell activation through negative regulation of IL2 expression by inhibiting calcineurin-NFAT pathway activation through interaction with NFATC2 (By similarity)..
• Protein Sequence: MGEQPIFTTRAHVFQIDPSTKKNWVPASKQAVTVSYFYDVTRNSYRIISVDGAKVIINSTITPNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVREAARLARDKSQEKIETSSNHSQESGCETPSSTQASSVNGTDDEKASHASPADTHLKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDRLRSKIEELEEQCGEINREKEKNTQLKRRIEELESEVREKEMELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKGELKSFLEVLDGKIDDLHDFRRGLSKLGTDN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
153	Phosphorylation	GTDDEKASHASPADT CCCCCHHCCCCCCHH	30.56	25403869
156	Phosphorylation	DEKASHASPADTHLK CCHHCCCCCCHHCCC	18.39	28432305
323	Acetylation	KYRQRHLKGELKSFL HHHHHHHHHHHHHHH	44.19	22902405
327	Acetylation	RHLKGELKSFLEVLD HHHHHHHHHHHHHHC	34.55	14496123

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HOME2_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HOME2_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HOME2_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GRM1_RAT	Grm1	physical	9808458

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.