HNRC2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HNRC2_HUMAN
• UniProt AC: B2RXH8
• Protein Name: Heterogeneous nuclear ribonucleoprotein C-like 2
• Gene Name: HNRNPCL2
• Organism: Homo sapiens (Human).
• Sequence Length: 293
• Subcellular Localization: Nucleus. Component of ribonucleosomes..
• Protein Description: May play a role in nucleosome assembly by neutralizing basic proteins such as A and B core hnRNPs..
• Protein Sequence: MASNVTNKMDPHSVNSRVFIGNLNTLVVKKSDVEAIFSKYGKIAGCSVHKGFAFVQYDKEKNARAAVAGEDGRMIASQVAVINLAAEPKVNRGNAGVKRSAAEMYGSSFDLDYGFQRDYYDGMYSFPARVPPPPPIALAVVPSKRQRISGNTSRRGKSGFNSKSGKRGSSKSGKLKGDDLQAIKQELTQIKQKVDSLLENLEKIEKEQSKQEVEVKNAKSEEEQSSSSMKKDETHVKMESEGGAEDSAEEGDPLDDDDNEDQGDNQLHLIKNNEKDAEEGEDNRDSTNGQDDS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MASNVTNKMD -----CCCCCCCCCC		-
25	Phosphorylation	VFIGNLNTLVVKKSD EEEECCCEEEEEHHH		30576142
29	Ubiquitination	NLNTLVVKKSDVEAI CCCEEEEEHHHHHHH		21890473
29	Ubiquitination	NLNTLVVKKSDVEAI CCCEEEEEHHHHHHH		23000965
30	Ubiquitination	LNTLVVKKSDVEAIF CCEEEEEHHHHHHHH		23000965
31	Phosphorylation	NTLVVKKSDVEAIFS CEEEEEHHHHHHHHH		30266825
38	Phosphorylation	SDVEAIFSKYGKIAG HHHHHHHHHHCCCCC		21712546
39	Sumoylation	DVEAIFSKYGKIAGC HHHHHHHHHCCCCCC		-
39	Ubiquitination	DVEAIFSKYGKIAGC HHHHHHHHHCCCCCC		21906983
39	Methylation	DVEAIFSKYGKIAGC HHHHHHHHHCCCCCC		37092753
39	Acetylation	DVEAIFSKYGKIAGC HHHHHHHHHCCCCCC		37092753
50	Ubiquitination	IAGCSVHKGFAFVQY CCCCEEECCEEEEEE		22817900
77	Phosphorylation	EDGRMIASQVAVINL CCCCEEEEEEEEEEH		22210691
100	Phosphorylation	GNAGVKRSAAEMYGS CCCCCCHHHHHHHCC		24043423
105	Phosphorylation	KRSAAEMYGSSFDLD CHHHHHHHCCCCCCC		18669648
107	Phosphorylation	SAAEMYGSSFDLDYG HHHHHHCCCCCCCCC		22496350
108	Phosphorylation	AAEMYGSSFDLDYGF HHHHHCCCCCCCCCC		24043423
113	Phosphorylation	GSSFDLDYGFQRDYY CCCCCCCCCCCCCCC		24043423
120	Phosphorylation	YGFQRDYYDGMYSFP CCCCCCCCCCCEECC		30576142
124	Phosphorylation	RDYYDGMYSFPARVP CCCCCCCEECCCCCC		30576142
125	Phosphorylation	DYYDGMYSFPARVPP CCCCCCEECCCCCCC		30576142
143	Phosphorylation	IALAVVPSKRQRISG EEEEECCCCCCCCCC		30266825
144	Ubiquitination	ALAVVPSKRQRISGN EEEECCCCCCCCCCC		24816145
144	Acetylation	ALAVVPSKRQRISGN EEEECCCCCCCCCCC		-
152	Phosphorylation	RQRISGNTSRRGKSG CCCCCCCCCCCCCCC		-
157	Acetylation	GNTSRRGKSGFNSKS CCCCCCCCCCCCCCC		1221632229
157	Ubiquitination	GNTSRRGKSGFNSKS CCCCCCCCCCCCCCC		27667366
158	Phosphorylation	NTSRRGKSGFNSKSG CCCCCCCCCCCCCCC		28985074
164	Phosphorylation	KSGFNSKSGKRGSSK CCCCCCCCCCCCCCC		22817900
169	Phosphorylation	SKSGKRGSSKSGKLK CCCCCCCCCCCCCCC		24260401
171	Ubiquitination	SGKRGSSKSGKLKGD CCCCCCCCCCCCCHH		23000965
172	Phosphorylation	GKRGSSKSGKLKGDD CCCCCCCCCCCCHHH		26546556
174	Acetylation	RGSSKSGKLKGDDLQ CCCCCCCCCCHHHHH		1206970561
174	Ubiquitination	RGSSKSGKLKGDDLQ CCCCCCCCCCHHHHH		23000965
176	Methylation	SSKSGKLKGDDLQAI CCCCCCCCHHHHHHH		-
176	Ubiquitination	SSKSGKLKGDDLQAI CCCCCCCCHHHHHHH		23000965
176	Sumoylation	SSKSGKLKGDDLQAI CCCCCCCCHHHHHHH		-
191	Ubiquitination	KQELTQIKQKVDSLL HHHHHHHHHHHHHHH		23000965
193	Ubiquitination	ELTQIKQKVDSLLEN HHHHHHHHHHHHHHH		21890473
193	Ubiquitination	ELTQIKQKVDSLLEN HHHHHHHHHHHHHHH		23000965
196	Phosphorylation	QIKQKVDSLLENLEK HHHHHHHHHHHHHHH		30266825
203	Ubiquitination	SLLENLEKIEKEQSK HHHHHHHHHHHHHHH		22817900
203	Acetylation	SLLENLEKIEKEQSK HHHHHHHHHHHHHHH		37092757
206	Ubiquitination	ENLEKIEKEQSKQEV HHHHHHHHHHHHHHH		22817900
210	Ubiquitination	KIEKEQSKQEVEVKN HHHHHHHHHHHHHHH		22817900
220	Phosphorylation	VEVKNAKSEEEQSSS HHHHHCCCHHHHCCC		28102081
225	Phosphorylation	AKSEEEQSSSSMKKD CCCHHHHCCCCCCCC		28102081
226	Phosphorylation	KSEEEQSSSSMKKDE CCHHHHCCCCCCCCC		28102081
227	Phosphorylation	SEEEQSSSSMKKDET CHHHHCCCCCCCCCC		28102081
228	Phosphorylation	EEEQSSSSMKKDETH HHHHCCCCCCCCCCC		28102081
234	Phosphorylation	SSMKKDETHVKMESE CCCCCCCCCEEEECC		-
240	Phosphorylation	ETHVKMESEGGAEDS CCCEEEECCCCCCCC		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HNRC2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HNRC2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HNRC2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of HNRC2_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.