HMOX1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HMOX1_RAT
• UniProt AC: P06762
• Protein Name: Heme oxygenase 1
• Gene Name: Hmox1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 289
• Subcellular Localization: Microsome. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side.
• Protein Description: Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis..
• Protein Sequence: MERPQLDSMSQDLSEALKEATKEVHIRAENSEFMRNFQKGQVSREGFKLVMASLYHIYTALEEEIERNKQNPVYAPLYFPEELHRRAALEQDMAFWYGPHWQEAIPYTPATQHYVKRLHEVGGTHPELLVAHAYTRYLGDLSGGQVLKKIAQKAMALPSSGEGLAFFTFPSIDNPTKFKQLYRARMNTLEMTPEVKHRVTEEAKTAFLLNIELFEELQALLTEEHKDQSPSQTEFLRQRPASLVQDTTSAETPRGKSQISTSSSQTPLLRWVLTLSFLLATVAVGIYAM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
18	Acetylation	QDLSEALKEATKEVH HHHHHHHHHHHHHHH	52.96	3937071
22	Acetylation	EALKEATKEVHIRAE HHHHHHHHHHHHHHC	65.86	3937053
39	Acetylation	EFMRNFQKGQVSREG HHHHHHHCCCCCHHH	47.36	3937047
48	Acetylation	QVSREGFKLVMASLY CCCHHHHHHHHHHHH	51.53	3937065
69	Acetylation	EEEIERNKQNPVYAP HHHHHHCCCCCCCCC	58.64	3937059
149	Acetylation	SGGQVLKKIAQKAMA CHHHHHHHHHHHHCC	38.83	18194664
153	Acetylation	VLKKIAQKAMALPSS HHHHHHHHHCCCCCC	30.98	18194664
179	Acetylation	IDNPTKFKQLYRARM CCCCHHHHHHHHHHH	40.73	3937083
196	Acetylation	LEMTPEVKHRVTEEA CCCCHHHHHHCCHHH	24.83	3937077
229	Phosphorylation	TEEHKDQSPSQTEFL CHHHCCCCHHHHHHH	36.33	25532521
231	Phosphorylation	EHKDQSPSQTEFLRQ HHCCCCHHHHHHHHH	55.79	22673903
233	Phosphorylation	KDQSPSQTEFLRQRP CCCCHHHHHHHHHCC	32.80	22673903
242	Phosphorylation	FLRQRPASLVQDTTS HHHHCCHHHHCCCCC	31.58	29779826
247	Phosphorylation	PASLVQDTTSAETPR CHHHHCCCCCCCCCC	12.93	23984901
248	Phosphorylation	ASLVQDTTSAETPRG HHHHCCCCCCCCCCC	33.94	23984901
249	Phosphorylation	SLVQDTTSAETPRGK HHHCCCCCCCCCCCC	26.63	23984901
252	Phosphorylation	QDTTSAETPRGKSQI CCCCCCCCCCCCCCC	20.29	22027198
257	Phosphorylation	AETPRGKSQISTSSS CCCCCCCCCCCCCCC	35.25	19700791
260	Phosphorylation	PRGKSQISTSSSQTP CCCCCCCCCCCCCCH	18.01	30181290
261	Phosphorylation	RGKSQISTSSSQTPL CCCCCCCCCCCCCHH	33.97	30181290
262	Phosphorylation	GKSQISTSSSQTPLL CCCCCCCCCCCCHHH	22.62	30181290
263	Phosphorylation	KSQISTSSSQTPLLR CCCCCCCCCCCHHHH	26.93	19700791
264	Phosphorylation	SQISTSSSQTPLLRW CCCCCCCCCCHHHHH	37.53	30181290
266	Phosphorylation	ISTSSSQTPLLRWVL CCCCCCCCHHHHHHH	20.18	30181290

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HMOX1_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HMOX1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HMOX1_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UBC_RAT	Ubc	physical	21073519

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.