HMGN5_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HMGN5_RAT
• UniProt AC: B4F777
• Protein Name: High mobility group nucleosome-binding domain-containing protein 5
• Gene Name: Hmgn5 {ECO:0000250|UniProtKB:P82970}
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 429
• Subcellular Localization: Nucleus . Associates with nucleosomes in euchromatin and is largely excluded from constitutive heterochromatin.
• Protein Description: Preferentially binds to euchromatin and modulates cellular transcription by counteracting linker histone-mediated chromatin compaction..
• Protein Sequence: MPKRKAAGDASQEPKRRSARLSAMPVPFTPELKPKRASTSRKTKTTNVVEESKDAGATTIPETKPEVVKGECNMENAENGEAKIIEAPISKMETEEVKEQINEDTEGDGGEKKEAVVTKGKNDELEANIQDVEKDEDEKEHEDTGEEGEDGEREGGLKEKPDVAEIEDAKEAKDDEEKEDKEKEDDKGGDGKKEEEKDDEGEAETEEEVKEQQKEETEGDDGKCKVEENKEGRKESQHEEEGKEELHEEDGKEDLHEEDGKEDLHEEDGKEDLHEEEGKEDLHEEEGKEDLHEEEGKEDLHEEEGKEDLHEEEGKEDLHEEEGKEDLHEEEGKEDLHEEDGKEGQHEEEGKEDLHEEEGKEDLHEEDGKEGQHEEDGKKKADGNEDRKEEEEQEAATEGNDENKVEVEEEADNKDFKEDGEKGEPVSTV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
29	Phosphorylation	SAMPVPFTPELKPKR HCCCCCCCCCCCCCC	15.13	28432305
33	Acetylation	VPFTPELKPKRASTS CCCCCCCCCCCCCCC	47.00	22902405
35	Acetylation	FTPELKPKRASTSRK CCCCCCCCCCCCCCC	60.04	22902405
44	Acetylation	ASTSRKTKTTNVVEE CCCCCCCCCCCCCHH	57.28	22902405
53	Acetylation	TNVVEESKDAGATTI CCCCHHHHCCCCCCC	55.68	22902405
64	Acetylation	ATTIPETKPEVVKGE CCCCCCCCCCEEECC	37.20	22902405
90	Phosphorylation	KIIEAPISKMETEEV EEEECCHHHCCHHHH	25.53	-
91	Acetylation	IIEAPISKMETEEVK EEECCHHHCCHHHHH	41.28	22902405
94	Phosphorylation	APISKMETEEVKEQI CCHHHCCHHHHHHHH	33.67	25575281
105	Phosphorylation	KEQINEDTEGDGGEK HHHHCCCCCCCCCCE	35.37	29779826
112	Acetylation	TEGDGGEKKEAVVTK CCCCCCCEEEEEEEC	60.22	22902405
119	Acetylation	KKEAVVTKGKNDELE EEEEEEECCCCCHHH	57.17	22902405
121	Acetylation	EAVVTKGKNDELEAN EEEEECCCCCHHHHH	63.88	22902405
144	Phosphorylation	DEKEHEDTGEEGEDG CHHHCCCCCCCCCCC	43.43	29779826
205	Phosphorylation	DDEGEAETEEEVKEQ CCCCCCCCHHHHHHH	56.60	22673903
333	Acetylation	DLHEEEGKEDLHEED HHHHHHCCCCCCCCC	51.87	22902405
360	Acetylation	DLHEEEGKEDLHEED HHCHHHCCCCCCCCC	51.87	72627259
422	Acetylation	DFKEDGEKGEPVSTV CCCCCCCCCCCCCCC	74.28	22902405

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HMGN5_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HMGN5_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HMGN5_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of HMGN5_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.