HMGN3_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HMGN3_RAT
• UniProt AC: Q66H40
• Protein Name: High mobility group nucleosome-binding domain-containing protein 3
• Gene Name: Hmgn3
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 95
• Subcellular Localization: Nucleus.
• Protein Description: Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular development and astrocyte function (By similarity)..
• Protein Sequence: MPKRKSPENAEGKDGAKLTKQEPTRRSARLSAKPVPPKPEPKPRKTSAKKEPGTKINRAAKGKKEEKQEAGKEGTAPSANGDTKAEEVLSTNASH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MPKRKSPENAEGK --CCCCCCCCCCCCC	41.29	29779826
13	Acetylation	SPENAEGKDGAKLTK CCCCCCCCCCCCCCC	44.48	22902405
17	Acetylation	AEGKDGAKLTKQEPT CCCCCCCCCCCCCCC	63.32	25786129
33	Acetylation	RSARLSAKPVPPKPE CCCHHCCCCCCCCCC	43.08	22902405
38	Acetylation	SAKPVPPKPEPKPRK CCCCCCCCCCCCCCC	56.81	22902405
55	Acetylation	AKKEPGTKINRAAKG CCCCCCHHHHHHHCC	43.85	22902405
72	Acetylation	EEKQEAGKEGTAPSA HHHHHHHCCCCCCCC	61.08	22902405
75	Phosphorylation	QEAGKEGTAPSANGD HHHHCCCCCCCCCCC	36.16	28432305
78	Phosphorylation	GKEGTAPSANGDTKA HCCCCCCCCCCCCCH	31.72	28432305
83	Phosphorylation	APSANGDTKAEEVLS CCCCCCCCCHHHHHH	33.29	28432305

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HMGN3_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HMGN3_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HMGN3_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of HMGN3_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.