HMGB4_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HMGB4_ARATH
• UniProt AC: Q42344
• Protein Name: High mobility group B protein 4
• Gene Name: HMGB4
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 138
• Subcellular Localization: Nucleus . Cytoplasm, cytosol .
• Protein Description: Binds preferentially double-stranded DNA..
• Protein Sequence: MKGGESKAEATSTDQRLKTRGRKAGKKTKKDPNQPKRPPSAFFVFLEDFRKEFNLANPNNKSVATVGKAAGARWKAMTDEDKAPYVAKAESRKTEYIKNVQQYNLKLASGTNREEDDSDKSKSEVDEAVSEEEAEDDD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
118	Phosphorylation	TNREEDDSDKSKSEV CCCCCCCCCHHHHHH	60.30	23776212
121	Phosphorylation	EEDDSDKSKSEVDEA CCCCCCHHHHHHHHH	46.54	23776212
123	Phosphorylation	DDSDKSKSEVDEAVS CCCCHHHHHHHHHHC	50.36	23776212
130	Phosphorylation	SEVDEAVSEEEAEDD HHHHHHHCHHHHHCC	46.46	30291188

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HMGB4_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HMGB4_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HMGB4_ARATH !!

Protein-Protein Interaction

Oops, there are no PPI records of HMGB4_ARATH !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale Arabidopsis phosphoproteome profiling reveals novelchloroplast kinase substrates and phosphorylation networks.";
Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,Grossmann J., Gruissem W., Baginsky S.;
Plant Physiol. 150:889-903(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-130, AND MASSSPECTROMETRY.
PubMed: 19376835

"Phosphoproteomic analysis of nuclei-enriched fractions fromArabidopsis thaliana.";
Jones A.M.E., MacLean D., Studholme D.J., Serna-Sanz A.,Andreasson E., Rathjen J.P., Peck S.C.;
J. Proteomics 72:439-451(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-130, AND MASSSPECTROMETRY.
PubMed: 19245862