dbPTM

HMGA1_RAT - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	HMGA1_RAT
UniProt AC	Q8K585
Protein Name	High mobility group protein HMG-I/HMG-Y
Gene Name	Hmga1
Organism	Rattus norvegicus (Rat).
Sequence Length	107
Subcellular Localization	Nucleus. Chromosome.
Protein Description	HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions (By similarity)..
Protein Sequence	MSESVSKSSQPLASKQEKDGTEKRGRGRPRKQPSVSPGTALVGSQKEPSEVPTPKRPRGRPKGSKNKGTAKTRKVTTTPGRKPRGRPKKLEKEEEEGISQESSEEEQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSESVSKSS ------CCCCCCCCC	38.28	27097102
2	Acetylation	------MSESVSKSS ------CCCCCCCCC	38.28	-
4	Phosphorylation	----MSESVSKSSQP ----CCCCCCCCCCC	25.12	27097102
6	Phosphorylation	--MSESVSKSSQPLA --CCCCCCCCCCCCC	35.78	23984901
7	Acetylation	-MSESVSKSSQPLAS -CCCCCCCCCCCCCC	52.55	22902405
8	ADP-ribosylation	MSESVSKSSQPLASK CCCCCCCCCCCCCCH	27.05	-
8	Phosphorylation	MSESVSKSSQPLASK CCCCCCCCCCCCCCH	27.05	23984901
9	Phosphorylation	SESVSKSSQPLASKQ CCCCCCCCCCCCCHH	39.28	23984901
9	ADP-ribosylation	SESVSKSSQPLASKQ CCCCCCCCCCCCCHH	39.28	-
15	Acetylation	SSQPLASKQEKDGTE CCCCCCCHHCCCCCC	57.79	25786129
18	Acetylation	PLASKQEKDGTEKRG CCCCHHCCCCCCCCC	59.99	22902405
26	Methylation	DGTEKRGRGRPRKQP CCCCCCCCCCCCCCC	41.82	-
26	Asymmetric dimethylarginine	DGTEKRGRGRPRKQP CCCCCCCCCCCCCCC	41.82	-
34 (in isoform 2)	Phosphorylation	-	32.50	27097102
34	Phosphorylation	GRPRKQPSVSPGTAL CCCCCCCCCCCCCCC	32.50	27097102
35 (in isoform 2)	Acetylation	-	11.58	-
36	Phosphorylation	PRKQPSVSPGTALVG CCCCCCCCCCCCCCC	23.19	27097102
38 (in isoform 2)	Phosphorylation	-	19.00	23984901
39	Phosphorylation	QPSVSPGTALVGSQK CCCCCCCCCCCCCCC	21.87	27097102
42 (in isoform 2)	Phosphorylation	-	6.86	28432305
44	Phosphorylation	PGTALVGSQKEPSEV CCCCCCCCCCCCCCC	30.51	27097102
49	Phosphorylation	VGSQKEPSEVPTPKR CCCCCCCCCCCCCCC	52.93	28432305
53	Phosphorylation	KEPSEVPTPKRPRGR CCCCCCCCCCCCCCC	46.77	27097102
58	Methylation	VPTPKRPRGRPKGSK CCCCCCCCCCCCCCC	58.76	-
58	Asymmetric dimethylarginine	VPTPKRPRGRPKGSK CCCCCCCCCCCCCCC	58.76	-
60	Methylation	TPKRPRGRPKGSKNK CCCCCCCCCCCCCCC	30.91	-
60	Asymmetric dimethylarginine	TPKRPRGRPKGSKNK CCCCCCCCCCCCCCC	30.91	-
64	Phosphorylation	PRGRPKGSKNKGTAK CCCCCCCCCCCCCCC	38.90	22817900
78	Phosphorylation	KTRKVTTTPGRKPRG CEEEEECCCCCCCCC	17.87	22817900
99	Phosphorylation	KEEEEGISQESSEEE HHHHCCCCCCCHHHC	38.46	23712012
102	Phosphorylation	EEGISQESSEEEQ-- HCCCCCCCHHHCC--	35.10	23712012
103	Phosphorylation	EGISQESSEEEQ--- CCCCCCCHHHCC---	48.55	23712012

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
36	S	Phosphorylation	Kinase	CDC2	P39951	Uniprot
36	S	Phosphorylation	Kinase	HIPK2	-	Uniprot
44	S	Phosphorylation	Kinase	PRKCA	P17252	GPS
44	S	Phosphorylation	Kinase	PRKCB	P05771	GPS
44	S	Phosphorylation	Kinase	PRKCD	Q05655	GPS
44	S	Phosphorylation	Kinase	PRKCG	P05129	GPS
53	T	Phosphorylation	Kinase	CDK1	P06493	PSP
53	T	Phosphorylation	Kinase	CDC2	P39951	Uniprot
53	T	Phosphorylation	Kinase	HIPK2	-	Uniprot
64	S	Phosphorylation	Kinase	PRKCA	P17252	GPS
64	S	Phosphorylation	Kinase	PRKCB	P05771	GPS
64	S	Phosphorylation	Kinase	PRKCD	Q05655	GPS
64	S	Phosphorylation	Kinase	PRKCG	P05129	GPS
78	T	Phosphorylation	Kinase	CDK1	P06493	PSP
78	T	Phosphorylation	Kinase	CDC2	P39951	Uniprot
78	T	Phosphorylation	Kinase	HIPK2	-	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
58	R	Methylation	-
Methylation at Arg-58 is mutually exclusive with methylation at Arg-60.
60	R	Methylation	-
Methylation at Arg-58 is mutually exclusive with methylation at Arg-60.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of HMGA1_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of HMGA1_RAT !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of HMGA1_RAT

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomics of vasopressin-sensitive renal cells:regulation of aquaporin-2 phosphorylation at two sites."; Hoffert J.D., Pisitkun T., Wang G., Shen R.-F., Knepper M.A.; Proc. Natl. Acad. Sci. U.S.A. 103:7159-7164(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-103, AND MASSSPECTROMETRY.	16641100 [Abstract]

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