UniProt ID | HME2_HUMAN | |
---|---|---|
UniProt AC | P19622 | |
Protein Name | Homeobox protein engrailed-2 | |
Gene Name | EN2 | |
Organism | Homo sapiens (Human). | |
Sequence Length | 333 | |
Subcellular Localization | Nucleus. | |
Protein Description | ||
Protein Sequence | MEENDPKPGEAAAAVEGQRQPESSPGGGSGGGGGSSPGEADTGRRRALMLPAVLQAPGNHQHPHRITNFFIDNILRPEFGRRKDAGTCCAGAGGGRGGGAGGEGGASGAEGGGGAGGSEQLLGSGSREPRQNPPCAPGAGGPLPAAGSDSPGDGEGGSKTLSLHGGAKKGGDPGGPLDGSLKARGLGGGDLSVSSDSDSSQAGANLGAQPMLWPAWVYCTRYSDRPSSGPRSRKPKKKNPNKEDKRPRTAFTAEQLQRLKAEFQTNRYLTEQRRQSLAQELSLNESQIKIWFQNKRAKIKKATGNKNTLAVHLMAQGLYNHSTTAKEGKSDSE | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
24 | Phosphorylation | GQRQPESSPGGGSGG CCCCCCCCCCCCCCC | 26.38 | 28387310 | |
29 | Phosphorylation | ESSPGGGSGGGGGSS CCCCCCCCCCCCCCC | 37.22 | 28387310 | |
35 | Phosphorylation | GSGGGGGSSPGEADT CCCCCCCCCCCCCCC | 36.31 | 27251275 | |
36 | Phosphorylation | SGGGGGSSPGEADTG CCCCCCCCCCCCCCC | 39.95 | 28387310 | |
42 | Phosphorylation | SSPGEADTGRRRALM CCCCCCCCCHHHHHH | 39.37 | - | |
87 | Phosphorylation | GRRKDAGTCCAGAGG CCCCCCCCCCCCCCC | 13.21 | 22210691 | |
96 | Methylation | CAGAGGGRGGGAGGE CCCCCCCCCCCCCCC | 43.81 | - | |
118 | Phosphorylation | GGGGAGGSEQLLGSG CCCCCCCCHHCCCCC | 22.66 | 22210691 | |
124 | Phosphorylation | GSEQLLGSGSREPRQ CCHHCCCCCCCCCCC | 33.30 | 22210691 | |
126 | Phosphorylation | EQLLGSGSREPRQNP HHCCCCCCCCCCCCC | 34.86 | 22210691 | |
148 | Phosphorylation | GPLPAAGSDSPGDGE CCCCCCCCCCCCCCC | 30.13 | 29978859 | |
150 | Phosphorylation | LPAAGSDSPGDGEGG CCCCCCCCCCCCCCC | 32.26 | 29978859 | |
158 | Phosphorylation | PGDGEGGSKTLSLHG CCCCCCCCCEEEECC | 33.07 | 29978859 | |
180 | O-linked_Glycosylation | PGGPLDGSLKARGLG CCCCCCCCCCCCCCC | 26.77 | 30379171 | |
195 | Phosphorylation | GGDLSVSSDSDSSQA CCCCEECCCCCCCCC | 38.69 | 22210691 | |
220 | Phosphorylation | WPAWVYCTRYSDRPS EEEEEEECCCCCCCC | 18.24 | 22210691 | |
222 | Phosphorylation | AWVYCTRYSDRPSSG EEEEECCCCCCCCCC | 9.21 | 22210691 | |
232 | Phosphorylation | RPSSGPRSRKPKKKN CCCCCCCCCCCCCCC | 48.03 | 20363803 | |
245 | Methylation | KNPNKEDKRPRTAFT CCCCHHCCCCCCCCC | 66.45 | 23644510 | |
245 | "N6,N6-dimethyllysine" | KNPNKEDKRPRTAFT CCCCHHCCCCCCCCC | 66.45 | - | |
276 | Phosphorylation | LTEQRRQSLAQELSL HHHHHHHHHHHHHCC | 24.70 | 15253423 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of HME2_HUMAN !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of HME2_HUMAN !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of HME2_HUMAN !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
FOXA2_HUMAN | FOXA2 | physical | 12642491 |
Kegg Disease | ||||||
---|---|---|---|---|---|---|
There are no disease associations of PTM sites. | ||||||
OMIM Disease | ||||||
There are no disease associations of PTM sites. | ||||||
Kegg Drug | ||||||
There are no disease associations of PTM sites. | ||||||
DrugBank | ||||||
There are no disease associations of PTM sites. |
loading...