HME2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HME2_HUMAN
• UniProt AC: P19622
• Protein Name: Homeobox protein engrailed-2
• Gene Name: EN2
• Organism: Homo sapiens (Human).
• Sequence Length: 333
• Subcellular Localization: Nucleus.
• Protein Sequence: MEENDPKPGEAAAAVEGQRQPESSPGGGSGGGGGSSPGEADTGRRRALMLPAVLQAPGNHQHPHRITNFFIDNILRPEFGRRKDAGTCCAGAGGGRGGGAGGEGGASGAEGGGGAGGSEQLLGSGSREPRQNPPCAPGAGGPLPAAGSDSPGDGEGGSKTLSLHGGAKKGGDPGGPLDGSLKARGLGGGDLSVSSDSDSSQAGANLGAQPMLWPAWVYCTRYSDRPSSGPRSRKPKKKNPNKEDKRPRTAFTAEQLQRLKAEFQTNRYLTEQRRQSLAQELSLNESQIKIWFQNKRAKIKKATGNKNTLAVHLMAQGLYNHSTTAKEGKSDSE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
24	Phosphorylation	GQRQPESSPGGGSGG CCCCCCCCCCCCCCC	26.38	28387310
29	Phosphorylation	ESSPGGGSGGGGGSS CCCCCCCCCCCCCCC	37.22	28387310
35	Phosphorylation	GSGGGGGSSPGEADT CCCCCCCCCCCCCCC	36.31	27251275
36	Phosphorylation	SGGGGGSSPGEADTG CCCCCCCCCCCCCCC	39.95	28387310
42	Phosphorylation	SSPGEADTGRRRALM CCCCCCCCCHHHHHH	39.37	-
87	Phosphorylation	GRRKDAGTCCAGAGG CCCCCCCCCCCCCCC	13.21	22210691
96	Methylation	CAGAGGGRGGGAGGE CCCCCCCCCCCCCCC	43.81	-
118	Phosphorylation	GGGGAGGSEQLLGSG CCCCCCCCHHCCCCC	22.66	22210691
124	Phosphorylation	GSEQLLGSGSREPRQ CCHHCCCCCCCCCCC	33.30	22210691
126	Phosphorylation	EQLLGSGSREPRQNP HHCCCCCCCCCCCCC	34.86	22210691
148	Phosphorylation	GPLPAAGSDSPGDGE CCCCCCCCCCCCCCC	30.13	29978859
150	Phosphorylation	LPAAGSDSPGDGEGG CCCCCCCCCCCCCCC	32.26	29978859
158	Phosphorylation	PGDGEGGSKTLSLHG CCCCCCCCCEEEECC	33.07	29978859
180	O-linked_Glycosylation	PGGPLDGSLKARGLG CCCCCCCCCCCCCCC	26.77	30379171
195	Phosphorylation	GGDLSVSSDSDSSQA CCCCEECCCCCCCCC	38.69	22210691
220	Phosphorylation	WPAWVYCTRYSDRPS EEEEEEECCCCCCCC	18.24	22210691
222	Phosphorylation	AWVYCTRYSDRPSSG EEEEECCCCCCCCCC	9.21	22210691
232	Phosphorylation	RPSSGPRSRKPKKKN CCCCCCCCCCCCCCC	48.03	20363803
245	Methylation	KNPNKEDKRPRTAFT CCCCHHCCCCCCCCC	66.45	23644510
245	"N6,N6-dimethyllysine"	KNPNKEDKRPRTAFT CCCCHHCCCCCCCCC	66.45	-
276	Phosphorylation	LTEQRRQSLAQELSL HHHHHHHHHHHHHCC	24.70	15253423

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HME2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HME2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HME2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FOXA2_HUMAN	FOXA2	physical	12642491

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.