HME2_HUMAN - dbPTM
HME2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID HME2_HUMAN
UniProt AC P19622
Protein Name Homeobox protein engrailed-2
Gene Name EN2
Organism Homo sapiens (Human).
Sequence Length 333
Subcellular Localization Nucleus.
Protein Description
Protein Sequence MEENDPKPGEAAAAVEGQRQPESSPGGGSGGGGGSSPGEADTGRRRALMLPAVLQAPGNHQHPHRITNFFIDNILRPEFGRRKDAGTCCAGAGGGRGGGAGGEGGASGAEGGGGAGGSEQLLGSGSREPRQNPPCAPGAGGPLPAAGSDSPGDGEGGSKTLSLHGGAKKGGDPGGPLDGSLKARGLGGGDLSVSSDSDSSQAGANLGAQPMLWPAWVYCTRYSDRPSSGPRSRKPKKKNPNKEDKRPRTAFTAEQLQRLKAEFQTNRYLTEQRRQSLAQELSLNESQIKIWFQNKRAKIKKATGNKNTLAVHLMAQGLYNHSTTAKEGKSDSE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
24PhosphorylationGQRQPESSPGGGSGG
CCCCCCCCCCCCCCC
26.3828387310
29PhosphorylationESSPGGGSGGGGGSS
CCCCCCCCCCCCCCC
37.2228387310
35PhosphorylationGSGGGGGSSPGEADT
CCCCCCCCCCCCCCC
36.3127251275
36PhosphorylationSGGGGGSSPGEADTG
CCCCCCCCCCCCCCC
39.9528387310
42PhosphorylationSSPGEADTGRRRALM
CCCCCCCCCHHHHHH
39.37-
87PhosphorylationGRRKDAGTCCAGAGG
CCCCCCCCCCCCCCC
13.2122210691
96MethylationCAGAGGGRGGGAGGE
CCCCCCCCCCCCCCC
43.81-
118PhosphorylationGGGGAGGSEQLLGSG
CCCCCCCCHHCCCCC
22.6622210691
124PhosphorylationGSEQLLGSGSREPRQ
CCHHCCCCCCCCCCC
33.3022210691
126PhosphorylationEQLLGSGSREPRQNP
HHCCCCCCCCCCCCC
34.8622210691
148PhosphorylationGPLPAAGSDSPGDGE
CCCCCCCCCCCCCCC
30.1329978859
150PhosphorylationLPAAGSDSPGDGEGG
CCCCCCCCCCCCCCC
32.2629978859
158PhosphorylationPGDGEGGSKTLSLHG
CCCCCCCCCEEEECC
33.0729978859
180O-linked_GlycosylationPGGPLDGSLKARGLG
CCCCCCCCCCCCCCC
26.7730379171
195PhosphorylationGGDLSVSSDSDSSQA
CCCCEECCCCCCCCC
38.6922210691
220PhosphorylationWPAWVYCTRYSDRPS
EEEEEEECCCCCCCC
18.2422210691
222PhosphorylationAWVYCTRYSDRPSSG
EEEEECCCCCCCCCC
9.2122210691
232PhosphorylationRPSSGPRSRKPKKKN
CCCCCCCCCCCCCCC
48.0320363803
245MethylationKNPNKEDKRPRTAFT
CCCCHHCCCCCCCCC
66.4523644510
245"N6,N6-dimethyllysine"KNPNKEDKRPRTAFT
CCCCHHCCCCCCCCC
66.45-
276PhosphorylationLTEQRRQSLAQELSL
HHHHHHHHHHHHHCC
24.7015253423

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of HME2_HUMAN !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of HME2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of HME2_HUMAN !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
FOXA2_HUMANFOXA2physical
12642491

Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of HME2_HUMAN

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Related Literatures of Post-Translational Modification

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