HME1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HME1_MOUSE
• UniProt AC: P09065
• Protein Name: Homeobox protein engrailed-1
• Gene Name: En1
• Organism: Mus musculus (Mouse).
• Sequence Length: 401
• Subcellular Localization: Nucleus.
• Protein Sequence: MEEQQPEPKSQRDSGLGAVAAAAPSGLSLSLSPGASGSSGSDGDSVPVSPQPAPPSPPAAPCLPPLAHHPHLPPHPPPPPPPPPPPPQHLAAPAHQPQPAAQLHRTTNFFIDNILRPDFGCKKEQPLPQLLVASAAAGGGAAAGGGSRVERDRGQTGAGRDPVHSLGTRASGAASLLCAPDANCGPPDGSQPATAVSAGASKAGNPAAAAAAAAAAAAAAVAAAAAAASKPSDSGGGSGGNAGSPGAQGAKFPEHNPAILLMGSANGGPVVKTDSQQPLVWPAWVYCTRYSDRPSSGPRTRKLKKKKNEKEDKRPRTAFTAEQLQRLKAEFQANRYITEQRRQTLAQELSLNESQIKIWFQNKRAKIKKATGIKNGLALHLMAQGLYNHSTTTVQDKDESE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
229	Phosphorylation	AAAAAAASKPSDSGG HHHHHHHCCCCCCCC	40.13	26160508
232	Phosphorylation	AAAASKPSDSGGGSG HHHHCCCCCCCCCCC	48.41	26160508
234	Phosphorylation	AASKPSDSGGGSGGN HHCCCCCCCCCCCCC	43.61	26160508
238	Phosphorylation	PSDSGGGSGGNAGSP CCCCCCCCCCCCCCC	46.96	26160508
244	Phosphorylation	GSGGNAGSPGAQGAK CCCCCCCCCCCCCCC	20.11	26160508
400	Phosphorylation	TVQDKDESE------ CCCCCCCCC------	59.76	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HME1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HME1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HME1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DKK1_MOUSE	Dkk1	genetic	15242796

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.