HME1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HME1_HUMAN
• UniProt AC: Q05925
• Protein Name: Homeobox protein engrailed-1
• Gene Name: EN1
• Organism: Homo sapiens (Human).
• Sequence Length: 392
• Subcellular Localization: Nucleus.
• Protein Sequence: MEEQQPEPKSQRDSALGAAAAATPGGLSLSLSPGASGSSGSGSDGDSVPVSPQPAPPSPPAAPCLPPLAHHPHLPPHPPPPPPQHLAAPAHQPQPAAQLHRTTNFFIDNILRPDFGCKKEQPPPQLLVAAAARGGAGGGGRVERDRGQTAAGRDPVHPLGTRAPGAASLLCAPDANCGPPDGSQPAAAGAGASKAGNPAAAAAAAAAAVAAAAAAAAAKPSDTGGGGSGGGAGSPGAQGTKYPEHGNPAILLMGSANGGPVVKTDSQQPLVWPAWVYCTRYSDRPSSGPRTRKLKKKKNEKEDKRPRTAFTAEQLQRLKAEFQANRYITEQRRQTLAQELSLNESQIKIWFQNKRAKIKKATGIKNGLALHLMAQGLYNHSTTTVQDKDESE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
149	Phosphorylation	VERDRGQTAAGRDPV CCCCCCCCCCCCCCC	22.69	21712546
168	Phosphorylation	TRAPGAASLLCAPDA CCCCCHHHEEECCCC	22.72	23898821
183	Phosphorylation	NCGPPDGSQPAAAGA CCCCCCCCCCCHHCC	40.13	23898821
193	Phosphorylation	AAAGAGASKAGNPAA CHHCCCCCCCCCHHH	23.32	23898821
221	Phosphorylation	AAAAAKPSDTGGGGS HHHHCCCCCCCCCCC	47.28	22199227
223	Phosphorylation	AAAKPSDTGGGGSGG HHCCCCCCCCCCCCC	41.90	22199227
228	Phosphorylation	SDTGGGGSGGGAGSP CCCCCCCCCCCCCCC	37.22	22199227
234	Phosphorylation	GSGGGAGSPGAQGTK CCCCCCCCCCCCCCC	21.45	22199227
335	Phosphorylation	ITEQRRQTLAQELSL HHHHHHHHHHHHHCC	23.42	26434776
345	Phosphorylation	QELSLNESQIKIWFQ HHHCCCHHHHHHHHH	35.81	26434776
381	Phosphorylation	AQGLYNHSTTTVQDK HHCCCCCCCCCCCCC	24.66	28348404
382	Phosphorylation	QGLYNHSTTTVQDKD HCCCCCCCCCCCCCC	20.95	28348404
383	Phosphorylation	GLYNHSTTTVQDKDE CCCCCCCCCCCCCCC	28.16	28348404
384	Phosphorylation	LYNHSTTTVQDKDES CCCCCCCCCCCCCCC	19.09	28348404
391	Phosphorylation	TVQDKDESE------ CCCCCCCCC------	59.76	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HME1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HME1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HME1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TLE1_HUMAN	TLE1	physical	16571670
TLE1_HUMAN	TLE1	physical	18611861

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.