HMCS1_MOUSE - dbPTM
HMCS1_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID HMCS1_MOUSE
UniProt AC Q8JZK9
Protein Name Hydroxymethylglutaryl-CoA synthase, cytoplasmic {ECO:0000305}
Gene Name Hmgcs1 {ECO:0000312|MGI:MGI:107592}
Organism Mus musculus (Mouse).
Sequence Length 520
Subcellular Localization Cytoplasm.
Protein Description This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase..
Protein Sequence MPGSLPLNAEACWPKDVGIVALEIYFPSQYVDQAELEKYDGVDAGKYTIGLGQARMGFCTDREDINSLCLTVVQKLMERHSLSYDCIGRLEVGTETIIDKSKSVKSNLMQLFEESGNTDIEGIDTTNACYGGTAAVFNAVNWVESSSWDGRYALVVAGDIAIYATGNARPTGGVGAVALLIGPNAPLIFDRGLRGTHMQHAYDFYKPDMLSEYPVVDGKLSIQCYLSALDRCYSVYRKKIRAQWQKEGKDKDFTLNDFGFMIFHSPYCKLVQKSLARMFLNDFLNDQNRDKNSIYSGLEAFGDVKLEDTYFDRDVEKAFMKASSELFNQKTKASLLVSNQNGNMYTSSVYGSLASVLAQYSPQQLAGKRVGVFSYGSGLAATLYSLKVTQDATPGSALDKITASLCDLKSRLDSRTCVAPDVFAENMKLREDTHHLANYIPQCSIDSLFEGTWYLVRVDEKHRRTYARRPFTNDHSLDEGMGLVHSNTATEHIPSPAKKVPRLPATSAESESAVISNGEH
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
4Phosphorylation----MPGSLPLNAEA
----CCCCCCCCCCH		22.4221082442
46AcetylationYDGVDAGKYTIGLGQ
CCCCCCCCEEEECCC		40.7223236377
46UbiquitinationYDGVDAGKYTIGLGQ
CCCCCCCCEEEECCC		40.72-
86GlutathionylationRHSLSYDCIGRLEVG
HCCCCCEEEEEEEEC		2.4224333276
94PhosphorylationIGRLEVGTETIIDKS
EEEEEECCEEEECCC		34.8220469934
96PhosphorylationRLEVGTETIIDKSKS
EEEECCEEEECCCHH		24.0720469934
100UbiquitinationGTETIIDKSKSVKSN
CCEEEECCCHHHHHH		49.74-
100AcetylationGTETIIDKSKSVKSN
CCEEEECCCHHHHHH		49.7466700027
205PhosphorylationMQHAYDFYKPDMLSE
CHHHHHCCCCCHHCC		20.7922802335
206UbiquitinationQHAYDFYKPDMLSEY
HHHHHCCCCCHHCCC		34.24-
206AcetylationQHAYDFYKPDMLSEY
HHHHHCCCCCHHCCC		34.2423236377
211PhosphorylationFYKPDMLSEYPVVDG
CCCCCHHCCCCEECC		28.5722802335
273UbiquitinationPYCKLVQKSLARMFL
HHHHHHHHHHHHHHH		39.7027667366
273MalonylationPYCKLVQKSLARMFL
HHHHHHHHHHHHHHH		39.7026320211
273AcetylationPYCKLVQKSLARMFL
HHHHHHHHHHHHHHH		39.7022826441
291UbiquitinationLNDQNRDKNSIYSGL
HHCCCCCCCCCCHHH		49.7327667366
317UbiquitinationYFDRDVEKAFMKASS
CCCHHHHHHHHHHCH		46.93-
317AcetylationYFDRDVEKAFMKASS
CCCHHHHHHHHHHCH		46.9323954790
321UbiquitinationDVEKAFMKASSELFN
HHHHHHHHHCHHHHC		38.3727667366
321AcetylationDVEKAFMKASSELFN
HHHHHHHHHCHHHHC		38.3722826441
330AcetylationSSELFNQKTKASLLV
CHHHHCCCCCEEEEE		53.7722826441
330UbiquitinationSSELFNQKTKASLLV
CHHHHCCCCCEEEEE		53.7727667366
374PhosphorylationGKRVGVFSYGSGLAA
CCEEEEEECCCHHHH		26.6125777480
375PhosphorylationKRVGVFSYGSGLAAT
CEEEEEECCCHHHHH		12.1225777480
377PhosphorylationVGVFSYGSGLAATLY
EEEEECCCHHHHHHH		23.5425777480
382PhosphorylationYGSGLAATLYSLKVT
CCCHHHHHHHEEEEC		22.1825777480
384PhosphorylationSGLAATLYSLKVTQD
CHHHHHHHEEEECCC		13.9625777480
385PhosphorylationGLAATLYSLKVTQDA
HHHHHHHEEEECCCC		25.4825777480
389PhosphorylationTLYSLKVTQDATPGS
HHHEEEECCCCCCCC		21.1025777480
393PhosphorylationLKVTQDATPGSALDK
EEECCCCCCCCHHHH		36.1525777480
396PhosphorylationTQDATPGSALDKITA
CCCCCCCCHHHHHHH		27.1925777480
400UbiquitinationTPGSALDKITASLCD
CCCCHHHHHHHHHCH		42.69-
409AcetylationTASLCDLKSRLDSRT
HHHHCHHHHHHCCCC		21.9322826441
409UbiquitinationTASLCDLKSRLDSRT
HHHHCHHHHHHCCCC		21.93-
417GlutathionylationSRLDSRTCVAPDVFA
HHHCCCCCCCCHHHH		2.0924333276
428UbiquitinationDVFAENMKLREDTHH
HHHHHHCCCCCCHHH		56.85-
428AcetylationDVFAENMKLREDTHH
HHHHHHCCCCCCHHH		56.8522826441
472PhosphorylationTYARRPFTNDHSLDE
HEECCCCCCCCCCCC		42.2825619855
476PhosphorylationRPFTNDHSLDEGMGL
CCCCCCCCCCCCCCE		40.1425619855
486PhosphorylationEGMGLVHSNTATEHI
CCCCEECCCCCCCCC		28.5325619855
488PhosphorylationMGLVHSNTATEHIPS
CCEECCCCCCCCCCC		37.6625619855
490PhosphorylationLVHSNTATEHIPSPA
EECCCCCCCCCCCCC		26.5125619855
495PhosphorylationTATEHIPSPAKKVPR
CCCCCCCCCCCCCCC		36.5726824392
498UbiquitinationEHIPSPAKKVPRLPA
CCCCCCCCCCCCCCC		58.65-
506PhosphorylationKVPRLPATSAESESA
CCCCCCCCCCCCCCC		26.9125619855
507PhosphorylationVPRLPATSAESESAV
CCCCCCCCCCCCCCC		31.9515345747
510PhosphorylationLPATSAESESAVISN
CCCCCCCCCCCCCCC		36.2525619855
512PhosphorylationATSAESESAVISNGE
CCCCCCCCCCCCCCC		36.8025619855
516PhosphorylationESESAVISNGEH---
CCCCCCCCCCCC---		31.9825521595
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of HMCS1_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of HMCS1_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of HMCS1_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of HMCS1_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of HMCS1_MOUSE

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Related Literatures of Post-Translational Modification

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