HMA2_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HMA2_ARATH
• UniProt AC: Q9SZW4
• Protein Name: Cadmium/zinc-transporting ATPase HMA2
• Gene Name: HMA2
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 951
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein .
• Protein Description: Plays an important role in zinc transport and homeostasis. Could also be involved in cadmium detoxification..
• Protein Sequence: MASKKMTKSYFDVLGICCTSEVPLIENILNSMDGVKEFSVIVPSRTVIVVHDTLILSQFQIVKALNQAQLEANVRVTGETNFKNKWPSPFAVVSGILLLLSFFKYLYSPFRWLAVAAVVAGIYPILAKAVASLARFRIDINILVVVTVGATIGMQDYTEAAVVVFLFTIAEWLQSRASYKASAVMQSLMSLAPQKAVIAETGEEVEVDELKTNTVIAVKAGETIPIDGVVVDGNCEVDEKTLTGEAFPVPKLKDSTVWAGTINLNGYITVNTTALAEDCVVAKMAKLVEEAQNSKTETQRFIDKCSKYYTPAIILISICFVAIPFALKVHNLKHWVHLALVVLVSACPCGLILSTPVATFCALTKAATSGLLIKGADYLETLAKIKIVAFDKTGTITRGEFIVMDFQSLSEDISLQSLLYWVSSTESKSSHPMAAAVVDYARSVSVEPKPEAVEDYQNFPGEGIYGKIDGKEVYIGNKRIASRAGCLSVPDIDVDTKGGKTIGYVYVGETLAGVFNLSDACRSGVAQAMKELKSLGIKIAMLTGDNHAAAMHAQEQLGNAMDIVRAELLPEDKSEIIKQLKREEGPTAMVGDGLNDAPALATADIGISMGVSGSALATETGNIILMSNDIRRIPQAIKLAKRAKRKVVENVVISITMKGAILALAFAGHPLIWAAVLADVGTCLLVILNSMLLLSDKHKTGNKCYRESSSSSVLIAEKLEGDAAGDMEAGLLPKISDKHCKPGCCGTKTQEKAMKPAKASSDHSHSGCCETKQKDNVTVVKKSCCAEPVDLGHGHDSGCCGDKSQQPHQHEVQVQQSCHNKPSGLDSGCCGGKSQQPHQHELQQSCHDKPSGLDIGTGPKHEGSSTLVNLEGDAKEELKVLVNGFCSSPADLAITSLKVKSDSHCKSNCSSRERCHHGSNCCRSYAKESCSHDHHHTRAHGVGTLKEIVIE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
443	Phosphorylation	AVVDYARSVSVEPKP HHHHHHHCCCCCCCH	15.57	28011693
445	Phosphorylation	VDYARSVSVEPKPEA HHHHHCCCCCCCHHH	23.24	28011693
708	Phosphorylation	GNKCYRESSSSSVLI CCCCCCCCCCCCEEE	26.90	25561503
709	Phosphorylation	NKCYRESSSSSVLIA CCCCCCCCCCCEEEE	29.50	25561503
710	Phosphorylation	KCYRESSSSSVLIAE CCCCCCCCCCEEEEE	35.59	25561503
711	Phosphorylation	CYRESSSSSVLIAEK CCCCCCCCCEEEEEH	26.81	25561503
712	Phosphorylation	YRESSSSSVLIAEKL CCCCCCCCEEEEEHH	23.92	25561503

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HMA2_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HMA2_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HMA2_ARATH !!

Protein-Protein Interaction

Oops, there are no PPI records of HMA2_ARATH !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.