HIRA_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HIRA_ARATH
• UniProt AC: Q9LXN4
• Protein Name: Protein HIRA
• Gene Name: HIRA
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 1024
• Subcellular Localization: Nucleus . Nucleus, nucleolus . Localized at rDNA loci in the nucleolus.
• Protein Description: Histone chaperone involved in maintining knox genes silencing throughout leaf development. [PubMed: 16243907 Involved in heterochromatic and euchromatic gene silencing, especially upon salt stress]
• Protein Sequence: MIAEKPFWVKHEGLQIFSIDVQPNGERFATGGGDHKVRIWNMKSVDKDLQNIDTKERLLATLRDHFGSVNCVRWAKNSRYVASGSDDQVIQIHERKPGSGTTEFGSGEAPDVENWKAVMTLRGHTADVVDLNWSPDDSMLASGSLDNTVHIWNMRTGMCTTVLRGHLSLVKGVTWDPIGSFIASQSDDKTVIIWRTSDWGMAHRTDGHWAKSLGSTFFRRLGWSPCGHFLTTTHGFQKPKHSAPVLERGEWSVAYDFLGHSAPIIVVRFNHSMFKRIPSSTHETKQVGWSNGTSKSGEKDLQSYNVIAMGSQDRTITVWTTGSARPLFVAKHFFGQSVVDLSWSPDGYSLFACSLDGTVAMIHFDPKELGVRLTDTELDELKKSRYGDVRGRQANLVESPAQLLLETASTKQAGSKRAASDVQQNQVTTKPSVSVESTAKRRKSQVDDRNKAAESTGQTLNKASTLNRVSSPVNQKVYRRPDGRKRIIPEAVGVPQQENNIMINGESHNFLPASAAAPAKGDSGDFPVEISNRDLSGKEIVCRNPDLKERSRITARATITESLVIEKVPGTSGRDGVLNVEQSVGIKESSSTDLLIRVFDWKDGEAAPPVCLEACPREHALDTVGAVSTSMVKETEISCKKSGETLWSDRIMGRVTVLAGNPNFWAAGCEDGSLQVYTKCGRRAMPTMMMGSAATFIDCDDSWKLLLVTRKGSLYVWDLFNRKCVLHDSLSSLVSSDVNLSSTVKGTIKVISVKLSKSGSPLVVLATRHAFLFDTSLMCWLRVADDCFPASNFSSSWNLGSAPCGELAGLQVDVRKYMARKPGWNRITDDGTQTRAHLESQLASSLALESPNEYRQCLLAYVRFLAREADESRLREVCESFLGPPTGMAEAASSDTNLSWDPYVLGVKKHKLLRNDILPAMASNRKVQRLLNEFIDLLSEYEDVETADPAPKGSTPTMNCGGVPSSLDQIGSDPPAMTATTPMTIDNDKPVSLENPAALDIGVCEKTGSEDRDKQDQNSRDSGS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
432	Phosphorylation	NQVTTKPSVSVESTA CCCCCCCCCCHHHHH	28.69	28011693
434	Phosphorylation	VTTKPSVSVESTAKR CCCCCCCCHHHHHHH	25.22	28011693
470	Phosphorylation	ASTLNRVSSPVNQKV HHHCCCCCCCCCCCC	26.20	25561503
471	Phosphorylation	STLNRVSSPVNQKVY HHCCCCCCCCCCCCE	29.97	25561503
571	Phosphorylation	VIEKVPGTSGRDGVL EEEECCCCCCCCCEE	23.18	28295753
572	Phosphorylation	IEKVPGTSGRDGVLN EEECCCCCCCCCEEE	37.43	28295753
673	Phosphorylation	AAGCEDGSLQVYTKC ECCCCCCCEEEEECC	28.13	28011693

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HIRA_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HIRA_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HIRA_ARATH !!

Protein-Protein Interaction

Oops, there are no PPI records of HIRA_ARATH !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.