HIPL2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HIPL2_HUMAN
• UniProt AC: Q6UWX4
• Protein Name: HHIP-like protein 2
• Gene Name: HHIPL2
• Organism: Homo sapiens (Human).
• Sequence Length: 724
• Subcellular Localization: Secreted .
• Protein Sequence: MLRTSTPNLCGGLHCRAPWLSSGILCLCLIFLLGQVGLLQGHPQCLDYGPPFQPPLHLEFCSDYESFGCCDQHKDRRIAARYWDIMEYFDLKRHELCGDYIKDILCQECSPYAAHLYDAENTQTPLRNLPGLCSDYCSAFHSNCHSAISLLTNDRGLQESHGRDGTRFCHLLDLPDKDYCFPNVLRNDYLNRHLGMVAQDPQGCLQLCLSEVANGLRNPVSMVHAGDGTHRFFVAEQVGVVWVYLPDGSRLEQPFLDLKNIVLTTPWIGDERGFLGLAFHPKFRHNRKFYIYYSCLDKKKVEKIRISEMKVSRADPNKADLKSERVILEIEEPASNHNGGQLLFGLDGYMYIFTGDGGQAGDPFGLFGNAQNKSSLLGKVLRIDVNRAGSHGKRYRVPSDNPFVSEPGAHPAIYAYGIRNMWRCAVDRGDPITRQGRGRIFCGDVGQNRFEEVDLILKGGNYGWRAKEGFACYDKKLCHNASLDDVLPIYAYGHAVGKSVTGGYVYRGCESPNLNGLYIFGDFMSGRLMALQEDRKNKKWKKQDLCLGSTTSCAFPGLISTHSKFIISFAEDEAGELYFLATSYPSAYAPRGSIYKFVDPSRRAPPGKCKYKPVPVRTKSKRIPFRPLAKTVLDLLKEQSEKAARKSSSATLASGPAQGLSEKGSSKKLASPTSSKNTLRGPGTKKKARVGPHVRQGKRRKSLKSHSGRMRPSAEQKRAGRSLP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
307	Phosphorylation	KVEKIRISEMKVSRA HCEEEEEEECEECCC	23.07	23532336
310	Acetylation	KIRISEMKVSRADPN EEEEEECEECCCCCC	32.76	7910723
318	Acetylation	VSRADPNKADLKSER ECCCCCCCCCCCCCE	48.98	7910733
395	Phosphorylation	AGSHGKRYRVPSDNP CCCCCCCEECCCCCC	21.32	-
414	Phosphorylation	PGAHPAIYAYGIRNM CCCCHHHHHHHHHHH	8.90	-
416	Phosphorylation	AHPAIYAYGIRNMWR CCHHHHHHHHHHHEE	8.98	-
480	N-linked_Glycosylation	YDKKLCHNASLDDVL CCCCCCCCCCHHHHH	30.17	UniProtKB CARBOHYD
568	Phosphorylation	THSKFIISFAEDEAG CCCCEEEEEEECCCC	17.37	-
631	Phosphorylation	PFRPLAKTVLDLLKE CCHHHHHHHHHHHHH	22.24	21130716
647	Phosphorylation	SEKAARKSSSATLAS HHHHHHHHCCCHHHC	24.79	18785766
648	Phosphorylation	EKAARKSSSATLASG HHHHHHHCCCHHHCC	27.33	18785766
651	Phosphorylation	ARKSSSATLASGPAQ HHHHCCCHHHCCCCC	25.46	-
654	Phosphorylation	SSSATLASGPAQGLS HCCCHHHCCCCCCCC	48.71	-
661	Phosphorylation	SGPAQGLSEKGSSKK CCCCCCCCCCCCCCC	44.05	-
675	Phosphorylation	KLASPTSSKNTLRGP CCCCCCCCCCCCCCC	32.19	27282143
678	Phosphorylation	SPTSSKNTLRGPGTK CCCCCCCCCCCCCCC	22.90	27282143
702	Phosphorylation	RQGKRRKSLKSHSGR CCCCCCHHHHCCCCC	38.94	25072903
705	Phosphorylation	KRRKSLKSHSGRMRP CCCHHHHCCCCCCCC	28.33	25072903
707	Phosphorylation	RKSLKSHSGRMRPSA CHHHHCCCCCCCCCH	34.87	25072903

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HIPL2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HIPL2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HIPL2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of HIPL2_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.