HGF_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HGF_RAT
• UniProt AC: P17945
• Protein Name: Hepatocyte growth factor
• Gene Name: Hgf
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 728
• Protein Description: Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization (By similarity)..
• Protein Sequence: MMWGTKLLPVLLLQHVLLHLLLLPVTIPYAEGQKKRRNTLHEFKKSAKTTLTKEDPLVKIKTKKVNSADECANRCIRNKGFPFTCKAFVFDKSRKRCYWYPFNSMSSGVKKGFGHEFDLYENKDYIRNCIIGKGGSYKGTVSITKSGIKCQPWNSMIPHEHSFLPSSYRGKDLQENYCRNPRGEEGGPWCFTSNPEVRYEVCDIPQCSEVECMTCNGESYRGPMDHTESGKTCQRWDQQTPHRHKFLPERYPDKGFDDNYCRNPDGKPRPWCYTLDPDTPWEYCAIKMCAHSAVNETDVPMETTECIKGQGEGYRGTTNTIWNGIPCQRWDSQYPHKHDITPENFKCKDLRENYCRNPDGAESPWCFTTDPNIRVGYCSQIPKCDVSSGQDCYRGNGKNYMGNLSKTRSGLTCSMWDKNMEDLHRHIFWEPDASKLTKNYCRNPDDDAHGPWCYTGNPLVPWDYCPISRCEGDTTPTIVNLDHPVISCAKTKQLRVVNGIPTQTTVGWMVSLKYRNKHICGGSLIKESWVLTARQCFPARNKDLKDYEAWLGIHDVHERGEEKRKQILNISQLVYGPEGSDLVLLKLARPAILDNFVSTIDLPSYGCTIPEKTTCSIYGWGYTGLINADGLLRVAHLYIMGNEKCSQHHQGKVTLNESELCAGAEKIGSGPCEGDYGGPLICEQHKMRMVLGVIVPGRGCAIPNRPGIFVRVAYYAKWIHKVILTYKL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
33	Pyrrolidone_carboxylic_acid	TIPYAEGQKKRRNTL CCCCCCCCHHHHCCH	39.33	-
33	Pyrrolidone_carboxylic_acid	TIPYAEGQKKRRNTL CCCCCCCCHHHHCCH	39.33	-
136	Phosphorylation	CIIGKGGSYKGTVSI CEECCCCCEECEEEE	32.13	26022182
140	Phosphorylation	KGGSYKGTVSITKSG CCCCEECEEEEECCC	13.61	26022182
295	N-linked_Glycosylation	MCAHSAVNETDVPME HHCCCCCCCCCCCCC	46.28	-
403	N-linked_Glycosylation	NGKNYMGNLSKTRSG CCCCCCCCCCCCCCC	25.31	-
569	N-linked_Glycosylation	EKRKQILNISQLVYG HHHHHHHHHHHHHHC	33.23	-
656	N-linked_Glycosylation	HQGKVTLNESELCAG CCCCCCCCHHHCCCC	41.19	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HGF_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HGF_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HGF_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of HGF_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.