HGD_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HGD_MOUSE
• UniProt AC: O09173
• Protein Name: Homogentisate 1,2-dioxygenase
• Gene Name: Hgd
• Organism: Mus musculus (Mouse).
• Sequence Length: 445
• Protein Sequence: MAELKYISGFGNECASEDPRCPGSLPKGQNNPQVCPYNLYAEQLSGSAFTCPRNTNKRSWLYRILPSVSHKPFESIDQGHVTHNWDEVGPDPNQLRWKPFEIPKASEKKVDFVSGLYTLCGAGDIKSNNGLAVHIFLCNSSMENRCFYNSDGDFLIVPQKGKLLIYTEFGKMSLQPNEICVIQRGMRFSVDVFEETRGYILEVYGVHFELPDLGPIGANGLANPRDFLIPVAWYEDRRVPGGYTVINKFQGKLFACKQDVSPFNVVAWHGNYTPYKYNLENFMVINAVAFDHADPSIFTVLTAKSLRPGVAIADFVIFPPRWGVADKTFRPPYYHRNCMSEFMGLIKGHYEAKQGGFLPGGGSLHSAMTPHGPDADCFEKASKAKLEPERIADGTMAFMFESSLSLAVTKWGLKTCSCLDENYYKCWEPLRSHFTPNSRSPTEPK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Acetylation	---MAELKYISGFGN ---CCCCEEECCCCC	31.85	22733758
14	S-palmitoylation	ISGFGNECASEDPRC ECCCCCCCCCCCCCC	6.15	28526873
14	S-nitrosylation	ISGFGNECASEDPRC ECCCCCCCCCCCCCC	6.15	22178444
21	S-nitrosylation	CASEDPRCPGSLPKG CCCCCCCCCCCCCCC	5.64	22178444
35	S-palmitoylation	GQNNPQVCPYNLYAE CCCCCCCCCCHHEEH	2.20	28526873
37	Phosphorylation	NNPQVCPYNLYAEQL CCCCCCCCHHEEHHH	16.81	17242355
40	Phosphorylation	QVCPYNLYAEQLSGS CCCCCHHEEHHHCCC	12.40	25521595
45	Phosphorylation	NLYAEQLSGSAFTCP HHEEHHHCCCCCCCC	30.32	30352176
47	Phosphorylation	YAEQLSGSAFTCPRN EEHHHCCCCCCCCCC	19.48	30352176
51	S-palmitoylation	LSGSAFTCPRNTNKR HCCCCCCCCCCCCCC	2.11	28526873
69	Phosphorylation	YRILPSVSHKPFESI HHHCCCCCCCCCCCC	30.08	23567750
71	Ubiquitination	ILPSVSHKPFESIDQ HCCCCCCCCCCCCCC	43.85	22790023
98	Acetylation	DPNQLRWKPFEIPKA CCCCCCCCCCCCCCC	33.14	-
98	Ubiquitination	DPNQLRWKPFEIPKA CCCCCCCCCCCCCCC	33.14	-
98	Malonylation	DPNQLRWKPFEIPKA CCCCCCCCCCCCCCC	33.14	26320211
104	Ubiquitination	WKPFEIPKASEKKVD CCCCCCCCCCCCCCC	70.92	22790023
104	Acetylation	WKPFEIPKASEKKVD CCCCCCCCCCCCCCC	70.92	23864654
109	Ubiquitination	IPKASEKKVDFVSGL CCCCCCCCCCEECHH	42.88	22790023
114	Phosphorylation	EKKVDFVSGLYTLCG CCCCCEECHHHHHHC	24.07	23984901
117	Phosphorylation	VDFVSGLYTLCGAGD CCEECHHHHHHCCCC	10.94	25521595
118	Phosphorylation	DFVSGLYTLCGAGDI CEECHHHHHHCCCCC	22.18	23984901
120	S-palmitoylation	VSGLYTLCGAGDIKS ECHHHHHHCCCCCCC	2.43	28526873
138	S-nitrosylation	LAVHIFLCNSSMENR EEEEEEEECCCCCCC	3.02	22178444
160	Ubiquitination	DFLIVPQKGKLLIYT CEEEECCCCEEEEEE	52.52	22790023
162	Ubiquitination	LIVPQKGKLLIYTEF EEECCCCEEEEEECC	47.35	-
162	Malonylation	LIVPQKGKLLIYTEF EEECCCCEEEEEECC	47.35	26073543
173	Phosphorylation	YTEFGKMSLQPNEIC EECCCCCCCCCCCEE	27.60	25521595
180	S-palmitoylation	SLQPNEICVIQRGMR CCCCCCEEEEECCCE	1.47	28526873
248	Ubiquitination	GGYTVINKFQGKLFA CCEEEEECCCCEEEE	28.13	22790023
252	Ubiquitination	VINKFQGKLFACKQD EEECCCCEEEEECCC	29.64	-
252	Malonylation	VINKFQGKLFACKQD EEECCCCEEEEECCC	29.64	26320211
327	Ubiquitination	PRWGVADKTFRPPYY CCCCCCCCCCCCCCC	39.56	22790023
333	Phosphorylation	DKTFRPPYYHRNCMS CCCCCCCCCCHHHHH	18.00	17242355
338	S-palmitoylation	PPYYHRNCMSEFMGL CCCCCHHHHHHHHHH	2.98	28526873
353	Malonylation	IKGHYEAKQGGFLPG HHCCEEHHCCCCCCC	37.22	26320211
353	Ubiquitination	IKGHYEAKQGGFLPG HHCCEEHHCCCCCCC	37.22	-
377	S-nitrosylation	PHGPDADCFEKASKA CCCCCHHHHHHHHHC	5.20	22178444
380	Ubiquitination	PDADCFEKASKAKLE CCHHHHHHHHHCCCC	37.39	22790023
385	Ubiquitination	FEKASKAKLEPERIA HHHHHHCCCCHHHHC	58.06	27667366
414	Succinylation	AVTKWGLKTCSCLDE HHHHHCCCCCCCCCC	43.47	23806337
414	Malonylation	AVTKWGLKTCSCLDE HHHHHCCCCCCCCCC	43.47	26320211
414	Succinylation	AVTKWGLKTCSCLDE HHHHHCCCCCCCCCC	43.47	-
414	Ubiquitination	AVTKWGLKTCSCLDE HHHHHCCCCCCCCCC	43.47	-
414	Acetylation	AVTKWGLKTCSCLDE HHHHHCCCCCCCCCC	43.47	23806337
416	S-palmitoylation	TKWGLKTCSCLDENY HHHCCCCCCCCCCCC	2.30	28526873
425	Ubiquitination	CLDENYYKCWEPLRS CCCCCCHHCCHHHHH	23.63	22790023
432	Phosphorylation	KCWEPLRSHFTPNSR HCCHHHHHCCCCCCC	30.54	22324799
435	Phosphorylation	EPLRSHFTPNSRSPT HHHHHCCCCCCCCCC	19.01	28609623
438	Phosphorylation	RSHFTPNSRSPTEPK HHCCCCCCCCCCCCC	35.03	25521595
440	Phosphorylation	HFTPNSRSPTEPK-- CCCCCCCCCCCCC--	35.67	22324799
442	Phosphorylation	TPNSRSPTEPK---- CCCCCCCCCCC----	67.19	28609623

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HGD_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HGD_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HGD_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of HGD_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.