HFM1_HUMAN - dbPTM
HFM1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID HFM1_HUMAN
UniProt AC A2PYH4
Protein Name Probable ATP-dependent DNA helicase HFM1
Gene Name HFM1
Organism Homo sapiens (Human).
Sequence Length 1435
Subcellular Localization
Protein Description Required for crossover formation and complete synapsis of homologous chromosomes during meiosis..
Protein Sequence MLKSNDCLFSLENLFFEKPDEVENHPDNEKSLDWFLPPAPLISEIPDTQELEEELESHKLLGQEKRPKMLTSNLKITNEDTNYISLTQKFQFAFPSDKYEQDDLNLEGVGNNDLSHIAGKLTYASQKYKNHIGTEIAPEKSVPDDTKLVNFAEDKGESTSVFRKRLFKISDNIHGSAYSNDNELDSHIGSVKIVQTEMNKGKSRNYSNSKQKFQYSANVFTANNAFSASEIGEGMFKAPSFSVAFQPHDIQEVTENGLGSLKAVTEIPAKFRSIFKEFPYFNYIQSKAFDDLLYTDRNFVICAPTGSGKTVVFELAITRLLMEVPLPWLNIKIVYMAPIKALCSQRFDDWKEKFGPIGLNCKELTGDTVMDDLFEIQHAHIIMTTPEKWDSMTRKWRDNSLVQLVRLFLIDEVHIVKDENRGPTLEVVVSRMKTVQSVSQTLKNTSTAIPMRFVAVSATIPNAEDIAEWLSDGERPAVCLKMDESHRPVKLQKVVLGFPCSSNQTEFKFDLTLNYKIASVIQMYSDQKPTLVFCATRKGVQQAASVLVKDAKFIMTVEQKQRLQKYAYSVRDSKLRDILKDGAAYHHAGMELSDRKVVEGAFTVGDLPVLFTTSTLAMGVNLPAHLVVIKSTMHYAGGLFEEYSETDILQMIGRAGRPQFDTTATAVIMTRLSTRDKYIQMLACRDTVESSLHRHLIEHLNAEIVLHTITDVNIAVEWIRSTLLYIRALKNPSHYGFASGLNKDGIEAKLQELCLKNLNDLSSLDLIKMDEGVNFKPTEAGRLMAWYYITFETVKKFYTISGKETLSDLVTLIAGCKEFLDIQLRINEKKTLNTLNKDPNRITIRFPMEGRIKTREMKVNCLIQAQLGCIPIQDFALTQDTAKIFRHGSRITRWLSDFVAAQEKKFAVLLNSLILAKCFRCKLWENSLHVSKQLEKIGITLSNAIVNAGLTSFKKIEETDARELELILNRHPPFGTQIKETVMYLPKYELKVEQITRYSDTTAEILVTVILRNFEQLQTKRTASDSHYVTLIIGDADNQVVYLHKITDSVLLKAGSWAKKIAVKRALKSEDLSINLISSEFVGLDIQQKLTVFYLEPKRFGNQITMQRKSETQISHSKHSDISTIAGPNKGTTASKKPGNRECNHLCKSKHTCGHDCCKIGVAQKSEIKESTISSYLSDLRNRNAVSSVPPVKRLKIQMNKSQSVDLKEFGFTPKPSLPSISRSEYLNISELPIMEQWDQPEIYGKVRQEPSEYQDKEVLNVNFELGNEVWDDFDDENLEVTSFSTDTEKTKISGFGNTLSSSTRGSKLPLQESKSKFQREMSNSFVSSHEMSDISLSNSAMPKFSASSMTKLPQQAGNAVIVHFQERKPQNLSPEIEKQCFTFSEKNPNSSNYKKVDFFIRNSECKKEVDFSMYHPDDEADEMKSLLGIFDGIF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
65UbiquitinationHKLLGQEKRPKMLTS
CCCCCCCCCCCHHHC		67.1429967540
71PhosphorylationEKRPKMLTSNLKITN
CCCCCHHHCCCEECC		16.4523909892
72PhosphorylationKRPKMLTSNLKITNE
CCCCHHHCCCEECCC		35.8822210691
77PhosphorylationLTSNLKITNEDTNYI
HHCCCEECCCCCCCE		30.8522210691
81PhosphorylationLKITNEDTNYISLTQ
CEECCCCCCCEEEEE		24.6028450419
83PhosphorylationITNEDTNYISLTQKF
ECCCCCCCEEEEEEE		8.2528450419
85PhosphorylationNEDTNYISLTQKFQF
CCCCCCEEEEEEEEE		18.2728450419
87PhosphorylationDTNYISLTQKFQFAF
CCCCEEEEEEEEEEC		23.9522210691
122PhosphorylationSHIAGKLTYASQKYK
HHHHHHHHHHCHHHH		22.1123663014
123PhosphorylationHIAGKLTYASQKYKN
HHHHHHHHHCHHHHC		18.0723663014
125PhosphorylationAGKLTYASQKYKNHI
HHHHHHHCHHHHCCC		19.4523663014
128PhosphorylationLTYASQKYKNHIGTE
HHHHCHHHHCCCCCC		14.9123663014
134PhosphorylationKYKNHIGTEIAPEKS
HHHCCCCCCCCCCCC		24.5023663014
273PhosphorylationEIPAKFRSIFKEFPY
HCCHHHHHHHHHCCC		35.1924719451
307PhosphorylationVICAPTGSGKTVVFE
EEEECCCCCCCHHHH		39.33-
393PhosphorylationPEKWDSMTRKWRDNS
HHHHHHHCHHHCCCH		32.80-
545PhosphorylationKGVQQAASVLVKDAK
HHHHHHHHHHHCCCE		20.99-
556PhosphorylationKDAKFIMTVEQKQRL
CCCEEEEEHHHHHHH		18.97-
662PhosphorylationAGRPQFDTTATAVIM
CCCCCCCHHHHHHHH		21.4428270605
663PhosphorylationGRPQFDTTATAVIMT
CCCCCCHHHHHHHHH		24.6928270605
665PhosphorylationPQFDTTATAVIMTRL
CCCCHHHHHHHHHCC		21.2622210691
670PhosphorylationTATAVIMTRLSTRDK
HHHHHHHHCCCCHHH		19.8228270605
673PhosphorylationAVIMTRLSTRDKYIQ
HHHHHCCCCHHHHHH		20.3628270605
674PhosphorylationVIMTRLSTRDKYIQM
HHHHCCCCHHHHHHH		47.6922210691
762PhosphorylationLKNLNDLSSLDLIKM
HCCCCCCCCCCEEEC		31.5522210691
763PhosphorylationKNLNDLSSLDLIKMD
CCCCCCCCCCEEECC		32.9522210691
788PhosphorylationGRLMAWYYITFETVK
HHHEEEEEEEHHHHH		5.2522817900
798PhosphorylationFETVKKFYTISGKET
HHHHHHHCCCCCCCC		16.4329396449
799PhosphorylationETVKKFYTISGKETL
HHHHHHCCCCCCCCH		16.29-
807PhosphorylationISGKETLSDLVTLIA
CCCCCCHHHHHHHHH		36.00-
831PhosphorylationLRINEKKTLNTLNKD
HHHCCCCCHHHCCCC		35.9929396449
843PhosphorylationNKDPNRITIRFPMEG
CCCCCCEEEEECCCC		11.6722985185
878PhosphorylationPIQDFALTQDTAKIF
EHHHEECCHHHHHHH		22.4422210691
881PhosphorylationDFALTQDTAKIFRHG
HEECCHHHHHHHHCC		21.7422210691
1053AcetylationITDSVLLKAGSWAKK
CCHHHHHHCCHHHHH		46.6890711
1059AcetylationLKAGSWAKKIAVKRA
HHCCHHHHHHHHHHH		38.1590713
1110PhosphorylationQITMQRKSETQISHS
EEEEEECCCCCCCCC		48.3325072903
1112PhosphorylationTMQRKSETQISHSKH
EEEECCCCCCCCCCC		37.9925072903
1115PhosphorylationRKSETQISHSKHSDI
ECCCCCCCCCCCCCC		16.3425072903
1117PhosphorylationSETQISHSKHSDIST
CCCCCCCCCCCCCCC		25.8525072903
1118AcetylationETQISHSKHSDISTI
CCCCCCCCCCCCCCC		41.5219821909
1120PhosphorylationQISHSKHSDISTIAG
CCCCCCCCCCCCCCC		40.1417693683
1123PhosphorylationHSKHSDISTIAGPNK
CCCCCCCCCCCCCCC		20.82-
1124PhosphorylationSKHSDISTIAGPNKG
CCCCCCCCCCCCCCC		18.38-
1130AcetylationSTIAGPNKGTTASKK
CCCCCCCCCCCCCCC		61.8519821917
1132PhosphorylationIAGPNKGTTASKKPG
CCCCCCCCCCCCCCC		22.31-
1133PhosphorylationAGPNKGTTASKKPGN
CCCCCCCCCCCCCCC		37.29-
1135PhosphorylationPNKGTTASKKPGNRE
CCCCCCCCCCCCCHH		38.84-
1136AcetylationNKGTTASKKPGNREC
CCCCCCCCCCCCHHH		61.6019821923
1171PhosphorylationQKSEIKESTISSYLS
CHHHHCHHHHHHHHH		26.49-
1172PhosphorylationKSEIKESTISSYLSD
HHHHCHHHHHHHHHH		26.43-
1178PhosphorylationSTISSYLSDLRNRNA
HHHHHHHHHHCCCCC		26.7724719451
1220PhosphorylationTPKPSLPSISRSEYL
CCCCCCCCCCHHHCC		38.1925002506
1222PhosphorylationKPSLPSISRSEYLNI
CCCCCCCCHHHCCCH		33.8122199227
1303PhosphorylationFGNTLSSSTRGSKLP
CCCCCCCCCCCCCCC		20.8130387612
1307PhosphorylationLSSSTRGSKLPLQES
CCCCCCCCCCCHHHH		27.94-
1323PhosphorylationSKFQREMSNSFVSSH
HHHHHHHHHCCCCHH		25.27-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of HFM1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of HFM1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of HFM1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of HFM1_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
615724Premature ovarian failure 9 (POF9)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of HFM1_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteome profiling of Wnt3a-mediated signalingnetwork: indicating the involvement of ribonucleoside-diphosphatereductase M2 subunit phosphorylation at residue serine 20 in canonicalWnt signal transduction.";
Tang L.-Y., Deng N., Wang L.-S., Dai J., Wang Z.-L., Jiang X.-S.,Li S.-J., Li L., Sheng Q.-H., Wu D.-Q., Li L., Zeng R.;
Mol. Cell. Proteomics 6:1952-1967(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1120, AND MASSSPECTROMETRY.

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