HFE_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HFE_HUMAN
• UniProt AC: Q30201
• Protein Name: Hereditary hemochromatosis protein
• Gene Name: HFE
• Organism: Homo sapiens (Human).
• Sequence Length: 348
• Subcellular Localization: Cell membrane ; Single-pass type I membrane protein .
• Protein Description: Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin..
• Protein Sequence: MGPRARPALLLLMLLQTAVLQGRLLRSHSLHYLFMGASEQDLGLSLFEALGYVDDQLFVFYDHESRRVEPRTPWVSSRISSQMWLQLSQSLKGWDHMFTVDFWTIMENHNHSKESHTLQVILGCEMQEDNSTEGYWKYGYDGQDHLEFCPDTLDWRAAEPRAWPTKLEWERHKIRARQNRAYLERDCPAQLQQLLELGRGVLDQQVPPLVKVTHHVTSSVTTLRCRALNYYPQNITMKWLKDKQPMDAKEFEPKDVLPNGDGTYQGWITLAVPPGEEQRYTCQVEHPGLDQPLIVIWEPSPSGTLVIGVISGIAVFVVILFIGILFIILRKRQGSRGAMGHYVLAERE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
17	Phosphorylation	LLLMLLQTAVLQGRL HHHHHHHHHHHHHHH	20.78	-
80	Phosphorylation	PWVSSRISSQMWLQL HHHHHHHHHHHHHHH	17.26	27174698
81	Phosphorylation	WVSSRISSQMWLQLS HHHHHHHHHHHHHHH	22.98	27174698
88	Phosphorylation	SQMWLQLSQSLKGWD HHHHHHHHHHCCCCC	12.55	27174698
90	Phosphorylation	MWLQLSQSLKGWDHM HHHHHHHHCCCCCEE	28.77	27174698
110	N-linked_Glycosylation	WTIMENHNHSKESHT HHHHHHCCCCCCCEE	53.35	UniProtKB CARBOHYD
130	N-linked_Glycosylation	GCEMQEDNSTEGYWK EEEECCCCCCCCCEE	50.51	UniProtKB CARBOHYD
165	Phosphorylation	AEPRAWPTKLEWERH CCCCCCCCCCHHHHH	37.24	29083192
166	Ubiquitination	EPRAWPTKLEWERHK CCCCCCCCCHHHHHH	40.09	-
234	N-linked_Glycosylation	ALNYYPQNITMKWLK HHCCCCCCCEEEHHC	27.48	UniProtKB CARBOHYD
342	Phosphorylation	SRGAMGHYVLAERE- CCCCCCEEEEEECC-	7.45	28674419

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HFE_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HFE_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HFE_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TFR1_HUMAN	TFRC	physical	9465039
SYVN1_HUMAN	SYVN1	physical	21245296

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.