HES5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HES5_HUMAN
• UniProt AC: Q5TA89
• Protein Name: Transcription factor HES-5
• Gene Name: HES5
• Organism: Homo sapiens (Human).
• Sequence Length: 166
• Subcellular Localization: Nucleus .
• Protein Description: Transcriptional repressor of genes that require a bHLH protein for their transcription. Plays an important role as neurogenesis negative regulator (By similarity)..
• Protein Sequence: MAPSTVAVELLSPKEKNRLRKPVVEKMRRDRINSSIEQLKLLLEQEFARHQPNSKLEKADILEMAVSYLKHSKAFVAAAGPKSLHQDYSEGYSWCLQEAVQFLTLHAASDTQMKLLYHFQRPPAAPAAPAKEPKAPGAAPPPALSAKATAAAAAAHQPACGLWRPW

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MAPSTVAVELL ----CCCCCHHHHHC	26.44	18491316
5	Phosphorylation	---MAPSTVAVELLS ---CCCCCHHHHHCC	16.07	23403867
12	Phosphorylation	TVAVELLSPKEKNRL CHHHHHCCHHHHHCC	46.69	18491316
34	Phosphorylation	MRRDRINSSIEQLKL HHHHHHCHHHHHHHH	30.26	-
35	Phosphorylation	RRDRINSSIEQLKLL HHHHHCHHHHHHHHH	26.17	-
72	Phosphorylation	AVSYLKHSKAFVAAA HHHHHHHCCHHHHHC	24.88	-
73	Acetylation	VSYLKHSKAFVAAAG HHHHHHCCHHHHHCC	45.63	24886875
82	Acetylation	FVAAAGPKSLHQDYS HHHHCCCCCCCCCHH	65.81	24886883
134	Ubiquitination	AAPAKEPKAPGAAPP CCCCCCCCCCCCCCC	69.20	20972266
166	Ubiquitination	ACGLWRPW------- CCCCCCCC-------	16.57	20972266

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
34	S	Phosphorylation	Kinase	AKT1	P31749	PSP
35	S	Phosphorylation	Kinase	AKT1	P31749	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HES5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HES5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
STAT3_HUMAN	STAT3	physical	15156153
JAK2_HUMAN	JAK2	physical	15156153

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.