dbPTM

HEMO_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	HEMO_MOUSE
UniProt AC	Q91X72
Protein Name	Hemopexin
Gene Name	Hpx
Organism	Mus musculus (Mouse).
Sequence Length	460
Subcellular Localization	Secreted.
Protein Description	Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation..
Protein Sequence	MARTAVALNILVLLGLCWSLAVASPLPTANGRVAEVENGTKPDSDVPEHCLDTWSFDAATMDHNGTMLFFKGEFVWRGHSGTRELISARWKNPITSVDAAFRGPDSVFLIKEDKVWVYPPEKKENGYPKLFQEEFPGIPYPPDAAVECHRGECQSEGVLFFQGNRKWFWDFATRTQKERSWSTVGNCTAALRWLERYYCFQGNKFLRFNPVTGEVPPRYPLDARDYFVSCPGRGHGRPRNGTAHGNSTHPMHSRCSPDPGLTALLSDHRGATYAFTGSHYWRLDSSRDGWHSWPIAHHWPQGPSTVDAAFSWDDKVYLIQGTQVYVFLTKGGNNLVSGYPKRLEKELGSPPGISLETIDAAFSCPGSSRLYVSSGRRLWWLDLKSGAQATWTEVSWPHEKVDGALCLDKSLGPNTCSSNGSSLYFIHGPNLYCYSSIDKLNAAKSLPQPQKVNSILGCSQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
38	N-linked_Glycosylation	GRVAEVENGTKPDSD CCEEEECCCCCCCCC	69.48	16944957
64	N-linked_Glycosylation	DAATMDHNGTMLFFK EEEEECCCCCEEEEE	43.28	-
91	Ubiquitination	ELISARWKNPITSVD HHHHHEECCCCCCCC	47.49	22790023
111	Ubiquitination	PDSVFLIKEDKVWVY CCEEEEEEECCEEEC	63.11	-
111	Succinylation	PDSVFLIKEDKVWVY CCEEEEEEECCEEEC	63.11	23954790
166	Ubiquitination	LFFQGNRKWFWDFAT EEEECCEEEEEEHHH	51.22	22790023
186	N-linked_Glycosylation	RSWSTVGNCTAALRW CCCCHHHHHHHHHHH	18.68	17330941
199	S-palmitoylation	RWLERYYCFQGNKFL HHHHHHEEECCCEEE	1.20	26165157
204	Ubiquitination	YYCFQGNKFLRFNPV HEEECCCEEEEEECC	53.23	22790023
230	S-palmitoylation	ARDYFVSCPGRGHGR CCCEEEECCCCCCCC	3.30	26165157
240	N-linked_Glycosylation	RGHGRPRNGTAHGNS CCCCCCCCCCCCCCC	55.65	-
246	N-linked_Glycosylation	RNGTAHGNSTHPMHS CCCCCCCCCCCCCCC	33.59	-
255	S-nitrosylation	THPMHSRCSPDPGLT CCCCCCCCCCCCCHH	8.52	22588120
255	S-palmitoylation	THPMHSRCSPDPGLT CCCCCCCCCCCCCHH	8.52	26165157
317	Phosphorylation	FSWDDKVYLIQGTQV EECCCEEEEEECCEE	12.11	20139300
419	N-linked_Glycosylation	GPNTCSSNGSSLYFI CCCCCCCCCCEEEEE	37.76	-
444	Ubiquitination	IDKLNAAKSLPQPQK HHHHHHCCCCCCCCH	50.55	27667366

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of HEMO_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of HEMO_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of HEMO_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of HEMO_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of HEMO_MOUSE

Related Literatures of Post-Translational Modification

N-linked Glycosylation
Reference	PubMed
"Enhanced analysis of the mouse plasma proteome using cysteine-containing tryptic glycopeptides."; Bernhard O.K., Kapp E.A., Simpson R.J.; J. Proteome Res. 6:987-995(2007). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-186, AND MASSSPECTROMETRY.	17330941 [Abstract]
"Proteome-wide characterization of N-glycosylation events by diagonalchromatography."; Ghesquiere B., Van Damme J., Martens L., Vandekerckhove J.,Gevaert K.; J. Proteome Res. 5:2438-2447(2006). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-38, AND MASS SPECTROMETRY.	16944957 [Abstract]