HEM61_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HEM61_ARATH
• UniProt AC: Q9LR75
• Protein Name: Coproporphyrinogen-III oxidase 1, chloroplastic
• Gene Name: CPX1
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 386
• Subcellular Localization: Plastid, chloroplast . Plastid .
• Protein Description: Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III..
• Protein Sequence: MASHSSTLLSSPTFAPFSSHRLHYSPNPSTLRFSRPIRNKPNLALRCSVSIEKEVPETERPFTFLRDSDDVTPSSSSSSVRARFETMIRAAQDSVCDAIEAIEGGPKFKEDVWSRPGGGGGISRVLQDGNVFEKAGVNVSVVYGVMPPEAYRAAKGSASDQKPGPVPFFAAGVSSVLHPKNPFAPTLHFNYRYFETDAPKDVPGAPRQWWFGGGTDFTPAYIFEEDVKHFHSIQKQACDKFDPSFYPRFKKWCDDYFYIKHRDERRGLGGIFFDDLNDYDQEMLLSFATECANSVVPAYIPIVEKRKDMEFTEQHKAWQQLRRGRYVEFNLVYDRGTTFGLKTGGRIESILVSLPLSARWEYDHKPEEGTEEWKLLDACINPKEWI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
72	Phosphorylation	LRDSDDVTPSSSSSS EECCCCCCCCCCCHH		25561503
76	Phosphorylation	DDVTPSSSSSSVRAR CCCCCCCCCHHHHHH		29654922
309	Sulfoxidation	IVEKRKDMEFTEQHK EEEHHCCCCHHHHHH		25693801

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HEM61_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HEM61_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HEM61_ARATH !!

Protein-Protein Interaction

Oops, there are no PPI records of HEM61_ARATH !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.