| UniProt ID | HEM2_RAT | |
|---|---|---|
| UniProt AC | P06214 | |
| Protein Name | Delta-aminolevulinic acid dehydratase | |
| Gene Name | Alad | |
| Organism | Rattus norvegicus (Rat). | |
| Sequence Length | 330 | |
| Subcellular Localization | ||
| Protein Description | Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity).. | |
| Protein Sequence | MHHQSVLHSGYFHPLLRAWQTTPSTVSATNLIYPIFVTDVPDDVQPIASLPGVARYGVNQLEEMLRPLVEAGLRCVLIFGVPSRVPKDEQGSAADSEDSPTIEAVRLLRKTFPTLLVACDVCLCPYTSHGHCGLLSENGAFLAEESRQRLAEVALAYAKAGCQVVAPSDMMDGRVEAIKAALLKHGLGNRVSVMSYSAKFASCFYGPFRDAAQSSPAFGDRRCYQLPPGARGLALRAVARDIQEGADILMVKPGLPYLDMVQEVKDKHPELPLAVYQVSGEFAMLWHGAKAGAFDLRTAVLESMTAFRRAGADIIITYFAPQLLKWLKEE | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 87 | Acetylation | GVPSRVPKDEQGSAA ECCCCCCCCCCCCCC | 71.66 | 22902405 | |
| 87 | Ubiquitination | GVPSRVPKDEQGSAA ECCCCCCCCCCCCCC | 71.66 | - | |
| 92 | Phosphorylation | VPKDEQGSAADSEDS CCCCCCCCCCCCCCC | 21.70 | 25575281 | |
| 96 | Phosphorylation | EQGSAADSEDSPTIE CCCCCCCCCCCHHHH | 38.28 | 25575281 | |
| 99 | Phosphorylation | SAADSEDSPTIEAVR CCCCCCCCHHHHHHH | 21.64 | 25575281 | |
| 184 | Acetylation | AIKAALLKHGLGNRV HHHHHHHHCCCCCCE | 36.15 | 22902405 | |
| 199 | Succinylation | SVMSYSAKFASCFYG EEEEEEHHHHHHHHC | 35.21 | - | |
| 199 | Succinylation | SVMSYSAKFASCFYG EEEEEEHHHHHHHHC | 35.21 | - | |
| 214 | Phosphorylation | PFRDAAQSSPAFGDR CCHHHHHCCCCCCCC | 33.30 | 28551015 | |
| 215 | Phosphorylation | FRDAAQSSPAFGDRR CHHHHHCCCCCCCCC | 14.25 | 21738781 | |
| 224 | Phosphorylation | AFGDRRCYQLPPGAR CCCCCCCCCCCCCHH | 15.98 | 16641100 | |
| 252 | Acetylation | GADILMVKPGLPYLD CCCEEEECCCCCCHH | 21.28 | 22902405 | |
| 252 | Succinylation | GADILMVKPGLPYLD CCCEEEECCCCCCHH | 21.28 | - | |
| 252 | Succinylation | GADILMVKPGLPYLD CCCEEEECCCCCCHH | 21.28 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of HEM2_RAT !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of HEM2_RAT !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of HEM2_RAT !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of HEM2_RAT !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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