HEM2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HEM2_MOUSE
• UniProt AC: P10518
• Protein Name: Delta-aminolevulinic acid dehydratase
• Gene Name: Alad
• Organism: Mus musculus (Mouse).
• Sequence Length: 330
• Protein Description: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity)..
• Protein Sequence: MHHQSVLHSGYFHPLLRSWQTAASTVSASNLIYPIFVTDVPDDVQPIASLPGVARYGVNQLEEMLRPLVEAGLRCVLIFGVPSRVPKDEQGSAADSEDSPTIEAVRLLRKTFPSLLVACDVCLCPYTSHGHCGLLSENGAFLAEESRQRLAEVALAYAKAGCQVVAPSDMMDGRVEAIKAALLKHGLGNRVSVMSYSAKFASCFYGPFRDAAQSSPAFGDRRCYQLPPGARGLALRAVARDIQEGADMLMVKPGLPYLDMVREVKDKHPELPLAVYQVSGEFAMLWHGAQAGAFDLRTAVLETMTAFRRAGADIIITYFAPQLLKWLKEE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
75	S-nitrosocysteine	LVEAGLRCVLIFGVP HHHCCCEEEEEEECC	3.34	-
75	S-palmitoylation	LVEAGLRCVLIFGVP HHHCCCEEEEEEECC	3.34	26165157
75	S-nitrosylation	LVEAGLRCVLIFGVP HHHCCCEEEEEEECC	3.34	21278135
87	Acetylation	GVPSRVPKDEQGSAA ECCCCCCCCCCCCCC	71.66	23954790
87	Ubiquitination	GVPSRVPKDEQGSAA ECCCCCCCCCCCCCC	71.66	22790023
92	Phosphorylation	VPKDEQGSAADSEDS CCCCCCCCCCCCCCC	21.70	26525534
96	Phosphorylation	EQGSAADSEDSPTIE CCCCCCCCCCCHHHH	38.28	26525534
110	Ubiquitination	EAVRLLRKTFPSLLV HHHHHHHHHHHHHHH	55.26	-
162	S-palmitoylation	LAYAKAGCQVVAPSD HHHHHCCCEEECCHH	3.11	28526873
162	S-nitrosylation	LAYAKAGCQVVAPSD HHHHHCCCEEECCHH	3.11	21278135
162	S-nitrosocysteine	LAYAKAGCQVVAPSD HHHHHCCCEEECCHH	3.11	-
179	Ubiquitination	DGRVEAIKAALLKHG CCHHHHHHHHHHHCC	34.35	22790023
179	Acetylation	DGRVEAIKAALLKHG CCHHHHHHHHHHHCC	34.35	22826441
184	Ubiquitination	AIKAALLKHGLGNRV HHHHHHHHCCCCCCE	36.15	-
184	Acetylation	AIKAALLKHGLGNRV HHHHHHHHCCCCCCE	36.15	22826441
184	Malonylation	AIKAALLKHGLGNRV HHHHHHHHCCCCCCE	36.15	26320211
199	Succinylation	SVMSYSAKFASCFYG EEEEEEHHHHHHHHC	35.21	-
199	Acetylation	SVMSYSAKFASCFYG EEEEEEHHHHHHHHC	35.21	23806337
199	Succinylation	SVMSYSAKFASCFYG EEEEEEHHHHHHHHC	35.21	23806337
202	Phosphorylation	SYSAKFASCFYGPFR EEEHHHHHHHHCCCH	14.11	23984901
203	S-palmitoylation	YSAKFASCFYGPFRD EEHHHHHHHHCCCHH	2.46	28526873
203	S-nitrosocysteine	YSAKFASCFYGPFRD EEHHHHHHHHCCCHH	2.46	-
203	S-nitrosylation	YSAKFASCFYGPFRD EEHHHHHHHHCCCHH	2.46	21278135
205	Phosphorylation	AKFASCFYGPFRDAA HHHHHHHHCCCHHHH	28.37	23984901
214	Phosphorylation	PFRDAAQSSPAFGDR CCHHHHHCCCCCCCC	33.30	25521595
215	Phosphorylation	FRDAAQSSPAFGDRR CHHHHHCCCCCCCCC	14.25	25521595
223	Glutathionylation	PAFGDRRCYQLPPGA CCCCCCCCCCCCCCH	2.36	24333276
224	Phosphorylation	AFGDRRCYQLPPGAR CCCCCCCCCCCCCHH	15.98	15577997
252	Succinylation	GADMLMVKPGLPYLD CCCEEEECCCCCHHH	21.28	23806337
252	Ubiquitination	GADMLMVKPGLPYLD CCCEEEECCCCCHHH	21.28	-
252	Acetylation	GADMLMVKPGLPYLD CCCEEEECCCCCHHH	21.28	23806337
252	Succinylation	GADMLMVKPGLPYLD CCCEEEECCCCCHHH	21.28	-
257	Phosphorylation	MVKPGLPYLDMVREV EECCCCCHHHHHHHH	22.00	138247

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HEM2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HEM2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HEM2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of HEM2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.