| UniProt ID | HECAM_HUMAN | |
|---|---|---|
| UniProt AC | Q14CZ8 | |
| Protein Name | Hepatocyte cell adhesion molecule | |
| Gene Name | HEPACAM {ECO:0000312|EMBL:AAI13563.1} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 416 | |
| Subcellular Localization |
Cytoplasm . Membrane Single-pass type I membrane protein Cytoplasmic side . In MCF-7 breast carcinoma and hepatic Hep 3B2.1-7 and Hep-G2 cell lines, localization of HEPACAM is cell density-dependent. In well spread cells, localized to punctate stru |
|
| Protein Description | Involved in regulating cell motility and cell-matrix interactions. May inhibit cell growth through suppression of cell proliferation.. | |
| Protein Sequence | MKRERGALSRASRALRLAPFVYLLLIQTDPLEGVNITSPVRLIHGTVGKSALLSVQYSSTSSDRPVVKWQLKRDKPVTVVQSIGTEVIGTLRPDYRDRIRLFENGSLLLSDLQLADEGTYEVEISITDDTFTGEKTINLTVDVPISRPQVLVASTTVLELSEAFTLNCSHENGTKPSYTWLKDGKPLLNDSRMLLSPDQKVLTITRVLMEDDDLYSCMVENPISQGRSLPVKITVYRRSSLYIILSTGGIFLLVTLVTVCACWKPSKRKQKKLEKQNSLEYMDQNDDRLKPEADTLPRSGEQERKNPMALYILKDKDSPETEENPAPEPRSATEPGPPGYSVSPAVPGRSPGLPIRSARRYPRSPARSPATGRTHSSPPRAPSSPGRSRSASRTLRTAGVHIIREQDEAGPVEISA | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 35 | N-linked_Glycosylation | TDPLEGVNITSPVRL CCCCCCCCCCCCEEE | 42.55 | UniProtKB CARBOHYD | |
| 138 | N-linked_Glycosylation | FTGEKTINLTVDVPI CCCEEEEEEEEECCC | 34.59 | UniProtKB CARBOHYD | |
| 167 | N-linked_Glycosylation | LSEAFTLNCSHENGT HHHEEECCCCCCCCC | 23.37 | UniProtKB CARBOHYD | |
| 189 | N-linked_Glycosylation | KDGKPLLNDSRMLLS ECCCCCCCCCCCCCC | 53.55 | UniProtKB CARBOHYD | |
| 191 | Phosphorylation | GKPLLNDSRMLLSPD CCCCCCCCCCCCCCC | 20.65 | 23401153 | |
| 278 | Phosphorylation | KKLEKQNSLEYMDQN HHHHHHCCHHHHCCC | 21.78 | 25072903 | |
| 278 (in isoform 2) | Phosphorylation | - | 21.78 | 29116813 | |
| 281 (in isoform 2) | Phosphorylation | - | 15.98 | 24076635 | |
| 281 | Phosphorylation | EKQNSLEYMDQNDDR HHHCCHHHHCCCCCC | 15.98 | 24076635 | |
| 290 | Ubiquitination | DQNDDRLKPEADTLP CCCCCCCCCCHHCCC | 41.53 | 30230243 | |
| 295 | Phosphorylation | RLKPEADTLPRSGEQ CCCCCHHCCCCCCHH | 45.79 | 20886841 | |
| 299 | Phosphorylation | EADTLPRSGEQERKN CHHCCCCCCHHHCCC | 44.75 | 29116813 | |
| 300 (in isoform 2) | Phosphorylation | - | 41.72 | 29116813 | |
| 304 (in isoform 2) | Phosphorylation | - | 43.69 | 29116813 | |
| 305 (in isoform 2) | Phosphorylation | - | 65.73 | 29116813 | |
| 305 | Ubiquitination | RSGEQERKNPMALYI CCCHHHCCCCEEEEE | 65.73 | 30230243 | |
| 316 | Ubiquitination | ALYILKDKDSPETEE EEEEECCCCCCCCCC | 59.52 | 30230243 | |
| 318 | Phosphorylation | YILKDKDSPETEENP EEECCCCCCCCCCCC | 30.31 | 20166139 | |
| 321 | Phosphorylation | KDKDSPETEENPAPE CCCCCCCCCCCCCCC | 52.57 | 25332170 | |
| 340 | Phosphorylation | TEPGPPGYSVSPAVP CCCCCCCCCCCCCCC | 16.21 | 24927040 | |
| 341 | Phosphorylation | EPGPPGYSVSPAVPG CCCCCCCCCCCCCCC | 23.25 | 28270605 | |
| 343 | Phosphorylation | GPPGYSVSPAVPGRS CCCCCCCCCCCCCCC | 10.95 | 28270605 | |
| 350 | Phosphorylation | SPAVPGRSPGLPIRS CCCCCCCCCCCCCCC | 29.27 | 29116813 | |
| 364 | Phosphorylation | SARRYPRSPARSPAT CCCCCCCCCCCCCCC | 20.57 | - | |
| 368 | Phosphorylation | YPRSPARSPATGRTH CCCCCCCCCCCCCCC | 22.46 | 23312004 | |
| 371 | Phosphorylation | SPARSPATGRTHSSP CCCCCCCCCCCCCCC | 30.49 | 23312004 | |
| 374 | Phosphorylation | RSPATGRTHSSPPRA CCCCCCCCCCCCCCC | 27.70 | 26033855 | |
| 376 | Phosphorylation | PATGRTHSSPPRAPS CCCCCCCCCCCCCCC | 43.88 | 24670416 | |
| 377 | Phosphorylation | ATGRTHSSPPRAPSS CCCCCCCCCCCCCCC | 31.17 | 20886841 | |
| 383 | Phosphorylation | SSPPRAPSSPGRSRS CCCCCCCCCCCCCCH | 48.45 | 20166139 | |
| 384 | Phosphorylation | SPPRAPSSPGRSRSA CCCCCCCCCCCCCHH | 30.25 | 20166139 | |
| 415 | Phosphorylation | EAGPVEISA------ CCCCCCCCC------ | 17.89 | 25332170 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of HECAM_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of HECAM_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of HECAM_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of HECAM_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| H00875 | Megalencephalic leukoencephalopathy with subcortical cysts (MLC) | |||||
| OMIM Disease | ||||||
| 613925 | Leukoencephalopathy, megalencephalic, with subcortical cysts, 2A (MLC2A) | |||||
| 613926 | Leukoencephalopathy, megalencephalic, with subcortical cysts, 2B (MLC2B) | |||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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