HEBP1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HEBP1_MOUSE
• UniProt AC: Q9R257
• Protein Name: Heme-binding protein 1
• Gene Name: Hebp1
• Organism: Mus musculus (Mouse).
• Sequence Length: 190
• Subcellular Localization: Cytoplasm .
• Protein Description: May bind free porphyrinogens that may be present in the cell and thus facilitate removal of these potentially toxic compound. Binds with a high affinity to one molecule of heme or porphyrins. It binds metalloporphyrins, free porphyrins and N-methylprotoporphyrin with similar affinities..
• Protein Sequence: MLGMIRNSLFGSVETWPWQVLSTGGKEDVSYEERACEGGKFATVEVTDKPVDEALREAMPKIMKYVGGTNDKGVGMGMTVPVSFALFPNEDGSLQKKLKVWFRIPNQFQGSPPAPSDESVKIEEREGITVYSTQFGGYAKEADYVAHATQLRTTLEGTPATYQGDVYYCAGYDPPMKPYGRRNEVWLVKA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
40	Ubiquitination	ERACEGGKFATVEVT HHHCCCCCEEEEEEC	42.56	22790023
40	Acetylation	ERACEGGKFATVEVT HHHCCCCCEEEEEEC	42.56	22826441
49	Ubiquitination	ATVEVTDKPVDEALR EEEEECCCCHHHHHH	37.26	22790023
64	Malonylation	EAMPKIMKYVGGTND HHHHHHHHHHCCCCC	40.01	26320211
64	Ubiquitination	EAMPKIMKYVGGTND HHHHHHHHHHCCCCC	40.01	-
93	Phosphorylation	LFPNEDGSLQKKLKV ECCCCCCCHHEEEEE	39.69	30352176
96	Ubiquitination	NEDGSLQKKLKVWFR CCCCCHHEEEEEEEE	66.42	22790023
111	Phosphorylation	IPNQFQGSPPAPSDE CCCCCCCCCCCCCCC	19.54	25521595
116	Phosphorylation	QGSPPAPSDESVKIE CCCCCCCCCCCEEEE	57.00	23140645
119	Phosphorylation	PPAPSDESVKIEERE CCCCCCCCEEEEEEC	33.43	23140645
121	Ubiquitination	APSDESVKIEEREGI CCCCCCEEEEEECCE	54.39	22790023
131	Phosphorylation	EREGITVYSTQFGGY EECCEEEEEECCCCC	9.43	22871156
132	Phosphorylation	REGITVYSTQFGGYA ECCEEEEEECCCCCC	16.05	22871156
138	Phosphorylation	YSTQFGGYAKEADYV EEECCCCCCCCCCEE	18.19	22871156
144	Phosphorylation	GYAKEADYVAHATQL CCCCCCCEEEEEEEE	13.44	-
149	Phosphorylation	ADYVAHATQLRTTLE CCEEEEEEEEEEECC	20.47	-
153	Phosphorylation	AHATQLRTTLEGTPA EEEEEEEEECCCCCC	44.30	-
154	Phosphorylation	HATQLRTTLEGTPAT EEEEEEEECCCCCCE	19.17	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HEBP1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HEBP1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HEBP1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of HEBP1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.