HEAT4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HEAT4_HUMAN
• UniProt AC: Q86WZ0
• Protein Name: HEAT repeat-containing protein 4
• Gene Name: HEATR4
• Organism: Homo sapiens (Human).
• Sequence Length: 1026
• Protein Sequence: MTRTQKGKTFLPHCFYQSLPPRLGWGMILNYSKLKGKEECASVSSVPMVFFSSQYRLHRKSQYLKMAAANLTFSQEVVWQRGLPSIPYSQYSFDHLYNTNDIIHTPQIRKARPQKPVSFKFLGSSSPLTGDTSLAVKTESSANPEKKLKKSKPASTVREAPRPLIHHPCMHPDMLGRPPSLDVNLEEREAWLLPPEKEARAWEATVLEKLNERTARWIQSKRPRRPGASPNKWQSFLRQQYDWSHIRDELTSASDLELLKQLEAEETAEFEDQSVILPPQEKKKPELLLPVYYRLPSYFQQAETVEIMPGNKSTEDIHEKTSLSQPQTQSYFRQVTPRAGKFAYSTDNTFEQEIYFDEVQIIHQIGAKRDQIVLENLNRYNKQLSKVFPETPEKWSAQAIPEASYRPVQGALRWTALPTPAKDMLLQVGEKDVPIKTRRLKKQAKSLQEDVTWELVVLRRMLKEWKTAWALIIEWHHETVENLLQSLGDLHDDVRIKAITTCATAALERPRIATSQRDSDKTIQDLPEVLLPALEAALCDKNAHVRMAAAICQYAIQSHNPLARNIMQTALLKGNSVDSWAAAQCLALEGTATYPVIKRILHQLFTKKNEDTEEQSYILLSYLSEKTTLIHTMLAVELNSCQWKNRIVACQAFSRISGNVCLDMKHKLIQLMWNDWNKEVRRAAAQALGQMSLGKEVHDIIRVKLGQGNSQERVEALYLIGELKLMTAKLLPSFLHCFSDDFTAVRRAACLAAGALQIRDKMVLECLLNLMQRDPYWKIKAFAIRALGQIGQVSPELTDLLLWAIHYEESPGVRLEACRSILALKLQGDRVRDTFLDVLLLENHDAVLKEMYQTMKILNLGNEGNQEMLQEIKNRIKTLSQKDLLTHKILKLEMVMGKVREEAKRVYLKPKGEQGPLTLQTLLQETFQDEMVLPRRPSEVCDTEAVIKPVKPRAPNPWLQSSVPGLTTRSKVRSSLVKDLRTSPEKRIAVGPFRSDYPALYLGKFSERTFFSPIMSSPSGKKGAHL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
18	Phosphorylation	LPHCFYQSLPPRLGW CCCCCCCCCCCCCCH	31.31	24719451
124	Phosphorylation	VSFKFLGSSSPLTGD EEEEECCCCCCCCCC	29.77	30622161
125	Phosphorylation	SFKFLGSSSPLTGDT EEEECCCCCCCCCCC	33.89	30622161
126	Phosphorylation	FKFLGSSSPLTGDTS EEECCCCCCCCCCCE	26.14	30622161
129	Phosphorylation	LGSSSPLTGDTSLAV CCCCCCCCCCCEEEE	36.07	25693802
132	Phosphorylation	SSPLTGDTSLAVKTE CCCCCCCCEEEECCC	27.30	25693802
133	Phosphorylation	SPLTGDTSLAVKTES CCCCCCCEEEECCCC	21.04	25693802
500	Phosphorylation	DVRIKAITTCATAAL HHHHHHHHHHHHHHH	22.23	-
522	Phosphorylation	SQRDSDKTIQDLPEV CCCCCCCCHHHHHHH	28.94	26330541
727	Phosphorylation	IGELKLMTAKLLPSF HHHHHHHHHHHHHHH	30.95	24719451
776	Phosphorylation	NLMQRDPYWKIKAFA HHHHHCCCHHHHHHH	24.51	22817900
794	Phosphorylation	LGQIGQVSPELTDLL HHCCCCCCHHHHHHH	12.55	20873877
798	Phosphorylation	GQVSPELTDLLLWAI CCCCHHHHHHHHHHH	23.96	20873877
807	Phosphorylation	LLLWAIHYEESPGVR HHHHHHHCCCCCCCC	18.45	20873877
810	Phosphorylation	WAIHYEESPGVRLEA HHHHCCCCCCCCHHH	18.27	20873877
820	Phosphorylation	VRLEACRSILALKLQ CCHHHHHHHHHHHHC	23.10	21815630
891	Acetylation	LLTHKILKLEMVMGK HHHHHHHHHHHHHHH	45.96	7670093
971	Acetylation	PGLTTRSKVRSSLVK CCCCCHHHHHHHHHH	38.07	7927359
974	Phosphorylation	TTRSKVRSSLVKDLR CCHHHHHHHHHHHHC	30.89	-
975	Phosphorylation	TRSKVRSSLVKDLRT CHHHHHHHHHHHHCC	26.98	19413330

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HEAT4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HEAT4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HEAT4_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of HEAT4_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-975, AND MASSSPECTROMETRY.
PubMed: 19413330