HEAT1_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HEAT1_DROME
• UniProt AC: Q9VM75
• Protein Name: HEAT repeat-containing protein 1 homolog
• Gene Name: l(2)k09022
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 2096
• Subcellular Localization: Nucleus, nucleolus.
• Protein Description: Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in ribosome biosynthesis (By similarity)..
• Protein Sequence: MSTALAQQLQKLAAPQSSVTLADARSRASILFDPKEAATKDRRSIYEIGLTGLQELTDFNPAFKEFQLTLFDEATLTLERSVELPEINKMLDAAIAKFLRLLSPYLLLRPAHMAFEWLLRRFQVHEYNRSEVMALILPYHETMIFVQIVKTMRLRSSDGDWYWLRPLQRPGVPLAKTAIINRAASNPAFLGFICQSTQKAVKELGPRAHQLQAQINFYATVVVGALQTAKPLQDWHITTILESLLRGLISDNIDFMAAAYVIVAQLVSRTKLKSKVCNALLERVANCPFERLHSESLLLLVCIYGKQQAALPHFKPETILNLVGKKWLISTLSSLAKGNIAIQSICMPLMTGAVAAIRDDDASSNSCKLFLDNLLSEVPMPKPTAQQLINCFLDTYVETAIDAPEPMETNSNEDDDTIVIDSDDEIETEKTTFQAWYSTYLEKLERRYPEAFDLSVKEALRSKSSTSNRQKALKLALGFRLNTTDEKAKHAYEKLYHYSADWRLSAVQKLLQNLNVTKKRERSVKLLQECLPDRINDDSGAVVSTLLSLPTEELAEMLGPLPLAQTLCHLLYRAQSEKDEEWQPVVPLAVRHLTSALVSGSYDTNLVLLALMPLLFPGEALAEHQHKALRILLGSDFVSKVPFLAELKVSNKFSDFNVGEHRQHFLDIIASSNQELSSQERALLQSVEDHGGELYIQKASQLTHLLLLLTAYAKRELQPRESLHMLEKIGLYSRRLQFRVVNGSQNTQNCAPLQLYVDFLLTLVKNTKWTALASTPWNQMTDELRLCLRLLEIICAQVFSEKADQPERQEWTRALQQSLQLILPEAQDRLEVLSNFYVFERLPELWPRDSDYAVFRLQGFIILEAVLSNPKSQIDCGLVHVLRVANACGSPLQTLRVQAINILQLISNRKLVSHVEQLVRSLLQRKSELSMDHEQYALILYTILEPEKATAKERLVLSKLKRSVLALASDPKQSPICTASLLAALKHVNDENFLNELLPLGLDSLKTITAGEDNQNIKQLPWPHSEIYKSVIERFEGRVALNVLLRKDLAWKLFEDSFAQYDTYVQLEQKLQPLPCVLLNSLTPETFEQMHAKHKIALIKLIVESATNSDNDSIFLASHRLLKRCRLDCQPLVPILLEMANTKVEKKQPVKRRSVQATQLDLTSPYWKQGMTLLELLEHKKQLVGAELLIPPLFELLQACLTMEEHSAAEYPKQLILSSLLHCCQTAQSAGVQLVKAMPESSFRIELVVQSLRNTRNPQTQQHALLFLTHCAGMYPQQVLHKIVEIFTFVGSTVARHDDAFSLHIIHNVVESIIPILLLNTGHNELVIPVLKVFADICTDVPVHRRLPLYATLFRVLEPKEHLWQFLCIIFESQVLLEQVPQKVSTDKSRLDFARELTLMFEDPTVAIQTCIRLLDYLAKLPATKSSLSGGSGSSVLSTEQQLFDVRTRTFKQLRHYKYLIMDFLSGISSCNEWEKKMKRPDPNELLPYYQEFILKTLAYVGVLNGALEAASETPSLEKFWRVLANHAHDVLDNAIGLLAPQHFISVITELLKHDHVYVRIKVMDLLVTKLSPSSDYFQQSNAEHFGVLFAPLQEIINGILEGSSNSAQQAKLQQTALHALQLLALRHGRDYIEECRSLLATLTKITKRRANVPKAVVGNVVLTLVEICASLKAHALAQLPKFAPQLTELLKEQVHQMASLKQGPDYVCSTLVTALHKLFKALPLFLGPYLVDIIGGLARLSVQLENPQLLQDKRTQVLKQKLADVWSAVAQGVEVRILVPSCAKAFSSLLEQQAYDELGHLMQQLLLQSVRHNSAAQLQPVQDPLSELFLQALNFRLQVRGLGLQRQLVSDVEASITETFVTWILKLSETSFRPMYSRVHKWALESTSRETRLTYFLLTNRIAEALKSLFVLFASDFVEDSSRLLTEHNSIRPEFEVEEREDDVDLLMAILNTLHHVFLYCSEDFINDHRFNVLMPPLVNQLENDLVLGNESLQQVLSNCIAQFAVATNDVMWKQLNSQVLLKTRTSNPEVRILAFNSCVAIARKLGESYAALLPETVPFIAELLEDEHQRVEKNTRTGVQELETILGESVQKYL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
35	Acetylation	ASILFDPKEAATKDR HHHHCCHHHHHCCCC	62.93	21791702
677	Phosphorylation	ASSNQELSSQERALL HCCCCCCCHHHHHHH	29.26	22817900
678	Phosphorylation	SSNQELSSQERALLQ CCCCCCCHHHHHHHH	49.00	22817900
1154	Phosphorylation	KQPVKRRSVQATQLD CCCCCCCCCCCCCCC	23.71	19429919
1887	Phosphorylation	VHKWALESTSRETRL HHHHHHHCCCCHHHH	32.31	22817900
1888	Phosphorylation	HKWALESTSRETRLT HHHHHHCCCCHHHHH	23.56	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HEAT1_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HEAT1_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HEAT1_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SIR2_DROME	Sir2	physical	14605208

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.