HEAT1_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HEAT1_ARATH
• UniProt AC: Q9C8Z4
• Protein Name: Uncharacterized protein At3g06530
• Gene Name: At3g06530
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 2197
• Subcellular Localization: Nucleus, nucleolus.
• Protein Description: Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in ribosome biosynthesis (By similarity)..
• Protein Sequence: MSSSIVSQLQALKSVLQADTEPSKRPFTRPSILFSPKEAADFDIESIYELGLKGLEVLGNKDERFKNYMNDLFSHKSKEIDRELLGKEENARIDSSISSYLRLLSGYLQFRASLETLEYLIRRYKIHIYNLEDVVLCALPYHDTHAFVRIVQLLSTGNSKWKFLDGVKNSGAPPPRSVIVQQCIRDKQVLEALCDYASRTKKYQPSKPVVSFSTAVVVGVLGSVPTVDGDIVKTILPFVDSGLQSGVKGCLDQQAGALMVVGMLANRAVLNTNLIKRLMRSIIDIGREHAKESSDPHSLRLSLMALINFVQLQSVDLIPRKALDLFNEIRDISGVLLGLSKEFNIKRFLAVLLDSLLFYSSSDDKCCEVLASIIETVPVSNLVDHLISKVFSLCMTQYQKNSDFRSSTSGSWAKKFLVVVSKKYPAELRAAVPKFLEATEVQSKKEDLKLEMLSCMLDGNSDMSHPFVDSKLWFRLHHPRAAVRCAALSSLNGVLKDDSSKAENLVTIQDAILRQLWDDDLAVVQAALSFDKLPNIITSSGLLDALLHVVKRCVGILVSGVSHNVQLAVDVVALSLKIAVSSFGNQTDSTEKVTSAMFPFLLIQPKTWNLNLLVLKLGKDVNWPLFKNLAADDGMKKLPDIMSTNLSSISMDIINDLGEALSLDPDERRIELIERACNYKLSEVLETCSNIKCSEQDRNKLQKGLLIRESVSALNIDVINKLVEAFMMHPADYIQWLTVSCRDSTLSKTLFYMILMHSLQKMNSSSDPSQLLDLFELCFPVLKTEWEELEVEVDVSLKELSKSNCQELLYQLLDTSDFTALNSKVLICLFWKLGESFIKLEPAHDASVLNKRLSSGLEDLFFFFATTRLRHVFKEHLHFRVREAKVCPVLFLSRLISREDVPPLVQIESLRCFSYLCSSGNNEWLIQVFSSFPVLLVPMSSDNQDVKAAAINCIEALFNLRAAIYGSSFDELLGMIVQQRRLILSDNKFFASYLTSLLSSTTNDLLVPVGLQKRFDQSTKENILSVILLCAEDLPAYGKLRVLSLLKDLGIMLMRDEIVKLLSQLLDKRSQYYYKLDKTSQPLSDTEVDLLCLLLECSMMRTSSFKGQSLDDHILSALNVDCMASERPAVISPCLTILEKLSNRFYDELQTDVQIRFFHKLVSMFRSSNGSIQNGAKEAVLRLKLSSSTVVLALDRITQQDTLVIGSLSKKKKQKKNSKSCPEEDINSEEFRSGEKALSFIASLLDMLLLKKDLTHRESLIRPLFKLLQRSMSKEWVKIAFSIEETSLQPPQDVRETTPTFISSIQQTLLLILKDIFDSLNMNPLKAEVANEINVKMLVELAHSSNDGVTRNHIFSLFTAIVKFVPDKVLDHIISILTLVGESTVTQIDSHSKSIFEGFISMVIPFWLSKTKSEEQLLQIFVKVLPDIVEHRRRSIVAYLLGVIGERNGLPALLVLLFKSLISRKDSAWLGNANVSESFASIVKKEWEYSFAMEICEQYSSSTWLSSLVILLQTISKDSKQCFLQMRLVLEFVFQKLQDPEFAFAVSLEPRNNVSVGIQQELQELMKCCICLLQAIDAKKEKDVTSSVRNEIRMRIHDVLMTVTGAMDLSIYFRVVTSLLQQQTDYNGTKKVLGLISERAKDTSSSKMKHKRKISNQKGRNSWLNLDEVAVDSFGKMCEEIVHLINATDDESGVPVKRAAISTLEVLAGRFPSGHPIFRKCLAAVAECISSKNLGVSSSCLRTTGALINVLGPKALIELPCIMKNLVKQSLEVSFASQSGRNATAEEQLLMLSVLVTLEAVIDKLGGFLNPHLGDIMKIMVLHPEYVSDFDKNLKSKANAIRRLLTDKIPVRLTLQPLLRIYNEAVSSGNASLVIAFNMLEDLVVKMDRSSIVSSHGKIFDQCLVALDIRRLNPAAIQNIDDAERSVTSAMVALTKKLTESEFRPLFIRSIDWAESDVVDGSGSENKSIDRAISFYGLVDRLCESHRSIFVPYFKYVLDGIVAHLTTAEASVSTRKKKKAKIQQTSDSIQPKSWHLRALVLSCLKNCFLHDTGSLKFLDTNNFQVLLKPIVSQLVVEPPSSLKEHPHVPSVDEVDDLLVSCIGQMAVASGSDLLWKPLNHEVLMQTRSESVRSRMLSLRSVKQMLDNLKEEYLVLLAETIPFLAELLEDVELSVKSLAQDIIKQMEEMSGESLAEYL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSSSIVSQL ------CCHHHHHHH	44.06	22223895
2	Phosphorylation	------MSSSIVSQL ------CCHHHHHHH	44.06	25561503
3	Phosphorylation	-----MSSSIVSQLQ -----CCHHHHHHHH	35.62	25561503
4	Phosphorylation	----MSSSIVSQLQA ----CCHHHHHHHHH	35.98	25561503
35	Phosphorylation	TRPSILFSPKEAADF CCCCCCCCHHHHCCC	31.45	25561503
1617	Phosphorylation	SIYFRVVTSLLQQQT HHHHHHHHHHHHHCC	15.70	28295753
1624	Phosphorylation	TSLLQQQTDYNGTKK HHHHHHCCCCCCHHH	35.79	28295753
1626	Phosphorylation	LLQQQTDYNGTKKVL HHHHCCCCCCHHHHH	20.91	28295753
1662	Phosphorylation	SNQKGRNSWLNLDEV CCCCCCCCCCCHHHH	31.42	30291188
2189	Phosphorylation	IKQMEEMSGESLAEY HHHHHHHCCCHHHHH	42.56	23776212
2192	Phosphorylation	MEEMSGESLAEYL-- HHHHCCCHHHHHC--	36.08	23776212
2196	Phosphorylation	SGESLAEYL------ CCCHHHHHC------	16.47	23776212

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HEAT1_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HEAT1_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HEAT1_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RL142_ARATH	AT4G27090	physical	21798944
MED7B_ARATH	AT5G03500	physical	21798944
CSN6B_ARATH	CSN6B	physical	21798944

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.