dbPTM

HCP3L_CAEEL - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	HCP3L_CAEEL
UniProt AC	P34440
Protein Name	Histone H3-like centromeric protein cpar-1
Gene Name	cpar-1 {ECO:0000303\|PubMed:16273096}
Organism	Caenorhabditis elegans.
Sequence Length	261
Subcellular Localization	Nucleus . Chromosome . Localizes to chromosomes during meiotic prometaphase I and metaphase I (PubMed:16273096, PubMed:25919583). Upon cleavage at the onset of anaphase I, the C-terminus remains localized to chromosomes (PubMed:25919583). The cleaved
Protein Description	Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. Not required for chromosome segregation during meiosis..
Protein Sequence	MADDGPIIEEIAEKNGRVARIMQRLQHDTQRVTSVPGFNTSATGYADLIALLDQYKNDLEAVGFNDLEQARRRAPSVDITVGSNSTNLVDYSHGRHDMPSHRRHDSSDEEITAANSHHQSPINVGNRNDTDGTNGRNGSRAGSSSSDRVRMIAGRNRISKTRRYRPGQKALEEIRKYQESEDLLIPKAPFARLVREIMQTSTPFSSDLRIRSDAINALQEASEALLVQMFDGSSLISAHSKRATLTTTDVQLYRRLCLPNL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
Oops, there are no PTM records of HCP3L_CAEEL !!

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of HCP3L_CAEEL !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of HCP3L_CAEEL !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of HCP3L_CAEEL !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of HCP3L_CAEEL !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of HCP3L_CAEEL

Related Literatures of Post-Translational Modification