HCN1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HCN1_RAT
• UniProt AC: Q9JKB0
• Protein Name: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
• Gene Name: Hcn1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 910
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein .
• Protein Description: Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). May mediate responses to sour stimuli..
• Protein Sequence: MEGGGKPNSASNSRDDGNSVYPSKAPATGPAAADKRLGTPPGGGAAGKEHGNSVCFKVDGGGGEEPAGSFEDAEGPRRQYGFMQRQFTSMLQPGVNKFSLRMFGSQKAVEKEQERVKTAGFWIIHPYSDFRFYWDLIMLIMMVGNLVIIPVGITFFTEQTTTPWIIFNVASDTVFLLDLIMNFRTGTVNEDSSEIILDPKVIKMNYLKSWFVVDFISSIPVDYIFLIVEKGMDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLCHWDGCLQFLVPLLQDFPPDCWVSLNEMVNDSWGKQYSYALFKAMSHMLCIGYGAQAPVSMSDLWITMLSMIVGATCYAMFVGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADMRQKIHDYYEHRYQGKIFDEENILSELNDPLREEIVNFNCRKLVATMPLFANADPNFVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVAGVITKSSKEMKLTDGSYFGEICLLTKGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILLQKFQKDLNTGVFNNQENEILKQIVKHDREMVQAIPPINYPQMTALNCTSSTTTPTSRMRTQSPPVYTATSLSHSNLHSPSPSTQTPQPSAILSPCSYTTAVCSPPIQSPLATRTFHYASPTASQLSLMQQPQPQLQQSQVQQTQTQTQQQQQQQQPQPQPQQPQQQQQQQQQQQQQQQQQQQQQPQTPGSSTPKNEVHKSTQALHNTHLTREVRPLSASQPSLPHEVSTMISRPHPTVGESLASIPQPVATVHSTGLQAGSRSTVPQRVTLFRQMSSGAIPPNRGVPPAPPPPAAVQRESPSVLNKDPDAEKPRFASNL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
39	Phosphorylation	AADKRLGTPPGGGAA HHHHHCCCCCCCCCC	30.79	30240740
69	Phosphorylation	GGEEPAGSFEDAEGP CCCCCCCCCCCCCCH	27.80	28432305
97	Ubiquitination	MLQPGVNKFSLRMFG HHCCCCCHHHHHHHC	33.64	-
327	N-linked_Glycosylation	VSLNEMVNDSWGKQY EEHHHHHCCCCHHHH	35.97	-
596	Ubiquitination	ILLQKFQKDLNTGVF HHHHHHHHHHCCCCC	68.28	-
867	Phosphorylation	VTLFRQMSSGAIPPN EEHHHHHCCCCCCCC	19.79	25403869
868	Phosphorylation	TLFRQMSSGAIPPNR EHHHHHCCCCCCCCC	27.23	25403869

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HCN1_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HCN1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HCN1_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of HCN1_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.