HCAR1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HCAR1_HUMAN
• UniProt AC: Q9BXC0
• Protein Name: Hydroxycarboxylic acid receptor 1
• Gene Name: HCAR1
• Organism: Homo sapiens (Human).
• Sequence Length: 346
• Subcellular Localization: Cell membrane; Multi-pass membrane protein.
• Protein Description: Acts as a receptor for L-lactate and mediates its anti-lipolytic effect through a G(i)-protein-mediated pathway..
• Protein Sequence: MYNGSCCRIEGDTISQVMPPLLIVAFVLGALGNGVALCGFCFHMKTWKPSTVYLFNLAVADFLLMICLPFRTDYYLRRRHWAFGDIPCRVGLFTLAMNRAGSIVFLTVVAADRYFKVVHPHHAVNTISTRVAAGIVCTLWALVILGTVYLLLENHLCVQETAVSCESFIMESANGWHDIMFQLEFFMPLGIILFCSFKIVWSLRRRQQLARQARMKKATRFIMVVAIVFITCYLPSVSARLYFLWTVPSSACDPSVHGALHITLSFTYMNSMLDPLVYYFSSPSFPKFYNKLKICSLKPKQPGHSKTQRPEEMPISNLGRRSCISVANSFQSQSDGQWDPHIVEWH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	N-linked_Glycosylation	-----MYNGSCCRIE -----CCCCCCEEEE	34.30	UniProtKB CARBOHYD
107	Phosphorylation	AGSIVFLTVVAADRY CCCEEEEEEEECCCC	11.06	22210691
202	Phosphorylation	CSFKIVWSLRRRQQL HHHHHHHHHHHHHHH	10.91	24719451
316	Phosphorylation	RPEEMPISNLGRRSC CCCCCCCCCCCHHHH	21.82	26657352
322	Phosphorylation	ISNLGRRSCISVANS CCCCCHHHHHHHHHC	17.91	28348404

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HCAR1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HCAR1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HCAR1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of HCAR1_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.