HBB1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HBB1_RAT
• UniProt AC: P02091
• Protein Name: Hemoglobin subunit beta-1
• Gene Name: Hbb
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 147
• Protein Description: Involved in oxygen transport from the lung to the various peripheral tissues..
• Protein Sequence: MVHLTDAEKAAVNGLWGKVNPDDVGGEALGRLLVVYPWTQRYFDSFGDLSSASAIMGNPKVKAHGKKVINAFNDGLKHLDNLKGTFAHLSELHCDKLHVDPENFRLLGNMIVIVLGHHLGKEFTPCAQAAFQKVVAGVASALAHKYH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MVHLTDAEK ------CCCCCHHHH	5.21	-
9	Acetylation	VHLTDAEKAAVNGLW CCCCHHHHHHHCCCC	43.28	22902405
18	Acetylation	AVNGLWGKVNPDDVG HHCCCCCCCCHHHCC	27.53	22902405
18	Succinylation	AVNGLWGKVNPDDVG HHCCCCCCCCHHHCC	27.53	-
18	Ubiquitination	AVNGLWGKVNPDDVG HHCCCCCCCCHHHCC	27.53	-
18	Succinylation	AVNGLWGKVNPDDVG HHCCCCCCCCHHHCC	27.53	-
36	Phosphorylation	LGRLLVVYPWTQRYF HHHHEEEECCCHHHH	5.88	22673903
39	Phosphorylation	LLVVYPWTQRYFDSF HEEEECCCHHHHHCC	9.92	23984901
42	Phosphorylation	VYPWTQRYFDSFGDL EECCCHHHHHCCCCC	11.26	21738781
45	Phosphorylation	WTQRYFDSFGDLSSA CCHHHHHCCCCCCCH	22.64	21738781
50	Phosphorylation	FDSFGDLSSASAIMG HHCCCCCCCHHHHCC	28.70	22673903
51	Phosphorylation	DSFGDLSSASAIMGN HCCCCCCCHHHHCCC	33.27	22673903
53	Phosphorylation	FGDLSSASAIMGNPK CCCCCCHHHHCCCCC	21.92	21738781
60	Ubiquitination	SAIMGNPKVKAHGKK HHHCCCCCHHHHCHH	61.44	-
60	Succinylation	SAIMGNPKVKAHGKK HHHCCCCCHHHHCHH	61.44	-
60	Acetylation	SAIMGNPKVKAHGKK HHHCCCCCHHHHCHH	61.44	22902405
60	Succinylation	SAIMGNPKVKAHGKK HHHCCCCCHHHHCHH	61.44	-
62	Ubiquitination	IMGNPKVKAHGKKVI HCCCCCHHHHCHHHH	40.57	-
66	Acetylation	PKVKAHGKKVINAFN CCHHHHCHHHHHHHH	33.72	22902405
67	Acetylation	KVKAHGKKVINAFND CHHHHCHHHHHHHHH	53.60	22902405
67	Succinylation	KVKAHGKKVINAFND CHHHHCHHHHHHHHH	53.60	26843850
67	Ubiquitination	KVKAHGKKVINAFND CHHHHCHHHHHHHHH	53.60	-
77	Acetylation	NAFNDGLKHLDNLKG HHHHHHHHHHHHCCH	47.88	22902405
77	Ubiquitination	NAFNDGLKHLDNLKG HHHHHHHHHHHHCCH	47.88	-
83	Acetylation	LKHLDNLKGTFAHLS HHHHHHCCHHHHHHH	63.26	22902405
85	Phosphorylation	HLDNLKGTFAHLSEL HHHHCCHHHHHHHHH	18.96	23984901
94	S-nitrosocysteine	AHLSELHCDKLHVDP HHHHHHCCCCCCCCH	8.46	-
94	S-nitrosylation	AHLSELHCDKLHVDP HHHHHHCCCCCCCCH	8.46	19101475
96	Acetylation	LSELHCDKLHVDPEN HHHHCCCCCCCCHHH	45.98	26302492
96	Ubiquitination	LSELHCDKLHVDPEN HHHHCCCCCCCCHHH	45.98	-
105	Methylation	HVDPENFRLLGNMIV CCCHHHHHHHHHHEE	40.35	-
105	Asymmetric dimethylarginine	HVDPENFRLLGNMIV CCCHHHHHHHHHHEE	40.35	-
121	Acetylation	VLGHHLGKEFTPCAQ ECCCCCCCCCHHHHH	56.89	26302492
124	Phosphorylation	HHLGKEFTPCAQAAF CCCCCCCHHHHHHHH	20.67	29779826
133	Acetylation	CAQAAFQKVVAGVAS HHHHHHHHHHHHHHH	32.02	22902405
140	Phosphorylation	KVVAGVASALAHKYH HHHHHHHHHHHHHCC	22.78	29779826
145	Acetylation	VASALAHKYH----- HHHHHHHHCC-----	39.14	22902405
145	Ubiquitination	VASALAHKYH----- HHHHHHHHCC-----	39.14	-
146	Phosphorylation	ASALAHKYH------ HHHHHHHCC------	11.68	21738781

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HBB1_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HBB1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HBB1_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of HBB1_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.