HBA_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HBA_RAT
• UniProt AC: P01946
• Protein Name: Hemoglobin subunit alpha-1/2
• Gene Name: Hba1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 142
• Protein Description: Involved in oxygen transport from the lung to the various peripheral tissues..
• Protein Sequence: MVLSADDKTNIKNCWGKIGGHGGEYGEEALQRMFAAFPTTKTYFSHIDVSPGSAQVKAHGKKVADALAKAADHVEDLPGALSTLSDLHAHKLRVDPVNFKFLSHCLLVTLACHHPGDFTPAMHASLDKFLASVSTVLTSKYR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MVLSADDKTNI ----CCCCCCCCCCH	20.45	22673903
8	Succinylation	MVLSADDKTNIKNCW CCCCCCCCCCHHHCC	43.98	-
8	Succinylation	MVLSADDKTNIKNCW CCCCCCCCCCHHHCC	43.98	-
8	Acetylation	MVLSADDKTNIKNCW CCCCCCCCCCHHHCC	43.98	26302492
9	Phosphorylation	VLSADDKTNIKNCWG CCCCCCCCCHHHCCC	49.52	-
12	Succinylation	ADDKTNIKNCWGKIG CCCCCCHHHCCCCCC	48.39	-
12	Acetylation	ADDKTNIKNCWGKIG CCCCCCHHHCCCCCC	48.39	22902405
12	Ubiquitination	ADDKTNIKNCWGKIG CCCCCCHHHCCCCCC	48.39	-
12	Succinylation	ADDKTNIKNCWGKIG CCCCCCHHHCCCCCC	48.39	26843850
17	Acetylation	NIKNCWGKIGGHGGE CHHHCCCCCCCCCHH	17.43	22902405
17	Succinylation	NIKNCWGKIGGHGGE CHHHCCCCCCCCCHH	17.43	-
17	Succinylation	NIKNCWGKIGGHGGE CHHHCCCCCCCCCHH	17.43	-
25	Phosphorylation	IGGHGGEYGEEALQR CCCCCHHHHHHHHHH	32.86	29779826
39	Phosphorylation	RMFAAFPTTKTYFSH HHHHHCCCCCCHHCC	34.18	23984901
40	Phosphorylation	MFAAFPTTKTYFSHI HHHHCCCCCCHHCCC	22.94	23984901
41	Ubiquitination	FAAFPTTKTYFSHID HHHCCCCCCHHCCCC	43.64	-
41	Succinylation	FAAFPTTKTYFSHID HHHCCCCCCHHCCCC	43.64	-
41	Succinylation	FAAFPTTKTYFSHID HHHCCCCCCHHCCCC	43.64	-
41	Acetylation	FAAFPTTKTYFSHID HHHCCCCCCHHCCCC	43.64	22902405
42	Phosphorylation	AAFPTTKTYFSHIDV HHCCCCCCHHCCCCC	27.92	22673903
43	Phosphorylation	AFPTTKTYFSHIDVS HCCCCCCHHCCCCCC	12.49	21738781
45	Phosphorylation	PTTKTYFSHIDVSPG CCCCCHHCCCCCCCC	14.77	25403869
50	Phosphorylation	YFSHIDVSPGSAQVK HHCCCCCCCCCHHHH	21.57	29779826
53	Phosphorylation	HIDVSPGSAQVKAHG CCCCCCCCHHHHHHH	20.93	25403869
57	Acetylation	SPGSAQVKAHGKKVA CCCCHHHHHHHHHHH	23.68	22902405
57	Ubiquitination	SPGSAQVKAHGKKVA CCCCHHHHHHHHHHH	23.68	-
61	Acetylation	AQVKAHGKKVADALA HHHHHHHHHHHHHHH	33.92	22902405
62	Ubiquitination	QVKAHGKKVADALAK HHHHHHHHHHHHHHH	47.44	-
62	Succinylation	QVKAHGKKVADALAK HHHHHHHHHHHHHHH	47.44	26843850
62	Acetylation	QVKAHGKKVADALAK HHHHHHHHHHHHHHH	47.44	22902405
69	Acetylation	KVADALAKAADHVED HHHHHHHHHHHHHHH	44.98	22902405
82	Phosphorylation	EDLPGALSTLSDLHA HHCCCHHHHHHHHHH	27.11	28826663
83	Phosphorylation	DLPGALSTLSDLHAH HCCCHHHHHHHHHHH	31.00	28826663
85	Phosphorylation	PGALSTLSDLHAHKL CCHHHHHHHHHHHCC	37.91	23984901
91	Ubiquitination	LSDLHAHKLRVDPVN HHHHHHHCCCCCCCC	38.48	-
91	Acetylation	LSDLHAHKLRVDPVN HHHHHHHCCCCCCCC	38.48	22902405
103	Phosphorylation	PVNFKFLSHCLLVTL CCCHHHHHHHHHHHH	18.45	-
109	Phosphorylation	LSHCLLVTLACHHPG HHHHHHHHHHHCCCC	14.49	-
125	Phosphorylation	FTPAMHASLDKFLAS CCHHHHHHHHHHHHH	23.56	-
128	Acetylation	AMHASLDKFLASVST HHHHHHHHHHHHHHH	47.79	26302492
132	Phosphorylation	SLDKFLASVSTVLTS HHHHHHHHHHHHHHC	20.81	22673903
134	Phosphorylation	DKFLASVSTVLTSKY HHHHHHHHHHHHCCC	15.42	22673903
135	Phosphorylation	KFLASVSTVLTSKYR HHHHHHHHHHHCCCC	19.85	22673903
138	Phosphorylation	ASVSTVLTSKYR--- HHHHHHHHCCCC---	20.88	22673903
139	Phosphorylation	SVSTVLTSKYR---- HHHHHHHCCCC----	24.43	23800682
140	Acetylation	VSTVLTSKYR----- HHHHHHCCCC-----	39.55	22902405

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HBA_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HBA_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HBA_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of HBA_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.