HAVR1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HAVR1_HUMAN
• UniProt AC: Q96D42
• Protein Name: Hepatitis A virus cellular receptor 1
• Gene Name: HAVCR1
• Organism: Homo sapiens (Human).
• Sequence Length: 359
• Subcellular Localization: Membrane ; Single-pass type I membrane protein .
• Protein Description: May play a role in T-helper cell development and the regulation of asthma and allergic diseases. Receptor for TIMD4 (By similarity). May play a role in kidney injury and repair.; (Microbial infection) Acts as a receptor for Hepatitis A virus.; (Microbial infection) Acts as a receptor for Ebolavirus and Marburg virus by binding exposed phosphatidyl-serine at the surface of virion membrane.; (Microbial infection) Acts as a receptor for Dengue virus by binding exposed phosphatidyl-serine at the surface of virion membrane..
• Protein Sequence: MHPQVVILSLILHLADSVAGSVKVGGEAGPSVTLPCHYSGAVTSMCWNRGSCSLFTCQNGIVWTNGTHVTYRKDTRYKLLGDLSRRDVSLTIENTAVSDSGVYCCRVEHRGWFNDMKITVSLEIVPPKVTTTPIVTTVPTVTTVRTSTTVPTTTTVPTTTVPTTMSIPTTTTVLTTMTVSTTTSVPTTTSIPTTTSVPVTTTVSTFVPPMPLPRQNHEPVATSPSSPQPAETHPTTLQGAIRREPTSSPLYSYTTDGNDTVTESSDGLWNNNQTQLFLEHSLLTANTTKGIYAGVCISVLVLLALLGVIIAKKYFFKKEVQQLSVSFSSLQIKALQNAVEKEVQAEDNIYIENSLYATD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
65	N-linked_Glycosylation	QNGIVWTNGTHVTYR CCCEEEECCCEEEEE	37.34	UniProtKB CARBOHYD
65	N-linked_Glycosylation	QNGIVWTNGTHVTYR CCCEEEECCCEEEEE	37.34	9557657
103	Phosphorylation	AVSDSGVYCCRVEHR CCCCCCEEEEEEEEC	6.86	-
210	O-linked_Glycosylation	VSTFVPPMPLPRQNH EEECCCCCCCCCCCC	4.33	OGP
222	Phosphorylation	QNHEPVATSPSSPQP CCCCCCCCCCCCCCC	41.21	24043423
223	Phosphorylation	NHEPVATSPSSPQPA CCCCCCCCCCCCCCC	17.04	18669648
225	Phosphorylation	EPVATSPSSPQPAET CCCCCCCCCCCCCCC	55.18	24043423
226	Phosphorylation	PVATSPSSPQPAETH CCCCCCCCCCCCCCC	30.82	24043423
228	Phosphorylation	ATSPSSPQPAETHPT CCCCCCCCCCCCCCC	52.35	18669648
232	Phosphorylation	SSPQPAETHPTTLQG CCCCCCCCCCCCHHH	34.95	24043423
235	Phosphorylation	QPAETHPTTLQGAIR CCCCCCCCCHHHHCC	32.31	24043423
236	Phosphorylation	PAETHPTTLQGAIRR CCCCCCCCHHHHCCC	22.87	24043423
240	O-linked_Glycosylation	HPTTLQGAIRREPTS CCCCHHHHCCCCCCC	4.52	OGP
258	N-linked_Glycosylation	YSYTTDGNDTVTESS EEEECCCCCEEEECC	44.59	UniProtKB CARBOHYD
263	N-linked_Glycosylation	DGNDTVTESSDGLWN CCCCEEEECCCCCCC	43.86	-
272	N-linked_Glycosylation	SDGLWNNNQTQLFLE CCCCCCCCCHHHHHH	42.96	UniProtKB CARBOHYD
277	N-linked_Glycosylation	NNNQTQLFLEHSLLT CCCCHHHHHHEECHH	5.60	-
286	N-linked_Glycosylation	EHSLLTANTTKGIYA HEECHHCCCCCCHHH	42.94	UniProtKB CARBOHYD
291	N-linked_Glycosylation	TANTTKGIYAGVCIS HCCCCCCHHHHHHHH	1.96	-
324	Phosphorylation	KKEVQQLSVSFSSLQ HHHHHHHEEEHHHHH	16.04	28857561
326	Phosphorylation	EVQQLSVSFSSLQIK HHHHHEEEHHHHHHH	18.94	28857561
328	Phosphorylation	QQLSVSFSSLQIKAL HHHEEEHHHHHHHHH	23.72	28857561
329	Phosphorylation	QLSVSFSSLQIKALQ HHEEEHHHHHHHHHH	23.45	28857561
341	Ubiquitination	ALQNAVEKEVQAEDN HHHHHHHHHHHHCCC	57.49	-
350	Phosphorylation	VQAEDNIYIENSLYA HHHCCCEEEECCEEE	14.40	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HAVR1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HAVR1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HAVR1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of HAVR1_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.