HASTY_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HASTY_ARATH
• UniProt AC: Q0WP44
• Protein Name: Protein HASTY 1
• Gene Name: HST1
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 1202
• Subcellular Localization: Nucleus . Nuclear periphery.
• Protein Description: Nucleocytoplasmic transporter involved in the nuclear export of microRNAs (miRNAs). Required for several miRNAs accumulation. Specifically required for miR156 accumulation which targets SPL3, SPL4 and SPL5 transcription factors. Involved in plant development through its role in miRNAs processing. Required for vegetative phase change and vegetative to reproductive phase transition. Functionally dependent on RAN1 binding. Does not seem to be involved in small interfering RNAs (siRNAs) processing..
• Protein Sequence: MEDSNSTASNVARAILAVVDFSSTSDTRKSAVQFLDSVKSGDVRVLAKTSFHLVKKEWSSEIRLHAFKMLQHLVRLRWDELSPPECRGLVNLSIELMSEVANASENWPLKSQSAALVAEIVRREGPDRWQEIFTLLTSLSAQGPLQAELVLMTLRWLPEDITIYNDDLEGDRRRLLLRGLTQSLPEILPLLYNLLERHFGAAMSEAGMQHFDLAKQHADVVIACLNAIVAYTEWAPVPDLARYGILSGCSFLLSSSDFRLHACEVFKLVCSRKRPSDASTAEFDSAISNLFQILTNASREFLCRSSSSSSVIDDNDYDFAVCMCESMASLGSTNLQSISSDGGVMAVYLQQMLGFFQHFKLGLHFEALLFWLSLMRDLLPKPKAATYPSGGGSSTGGDDSSSQVDSEKKKTLSLINDDISSAILDVSFQRMLKKEKVPTGIALSLGPLELWSDEFEGKGDFGPYRSKLLELIKLTASHKPLISSTKISERVITLIKHLLASPAPLQHVAVMDSQQLALDCIVATLFDGSNEFAGGSSEVHYALRGIFEGLLQQLLSLKWNEPELMKVHVHYLDAMGPFLKYFPDAVGSLINKLFELLTSLPHVVKDPATSTSRAARLQICTSFIRIAKAAEKSVLPHMKGIADTMGYLAKEGTLLRGEHNILGEAFLVMASSAGAQQQQEVLAWLLEPLSQQWIQPEWQNNYLSDPMGLVRLCSNTSFMWSIYHTVTFFEKALKRSGYRKSNLNTTSATTPASHPMAHHLSWMLPPLLKLLRVLHSLWSPSVFQTLPPEMRAAMTMTDAERYSLLGEANPKLSKGVSVYADGSFEGTKEGQAEASESDIRNWLKGIRDCGYNVLGLSTTIGETFFKCLDANYVAMALMENLQSMEFRHIRLFIHTFITYIVKSCPADMWESWLGVLLHPLFIHCQQALSSAWPGLLQEGRAKVPDLFGIQSGSDMKLEVMEEKLLRDLTREIATLFSTMASPGLNTGVPVLEHSGHVGRVDMSTLTDLHAFRSNSMVGFLLNHKSVALPALQICLETFTWTDGEATTKVCYFCGVVVLLAKLTNNVELREFVSKDMFSAVIRGLGMESNAINSPDLVNICREIFIYLSDRDPAPRQVLLSLPCLTPNDLHAFEEATAKTSSPKEQKQLMRSLLLLGTGNNLKALAAQKSQNVITNVTARTRLPASAPETIGAGVLWDEEFVQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEDSNSTA -------CCCCCHHH	51.28	22223895
581	Phosphorylation	AMGPFLKYFPDAVGS HCCHHHHHCHHHHHH	23.61	19880383
598	Phosphorylation	NKLFELLTSLPHVVK HHHHHHHHCCCHHHC	40.62	25368622
599	Phosphorylation	KLFELLTSLPHVVKD HHHHHHHCCCHHHCC	39.61	25368622
609	Phosphorylation	HVVKDPATSTSRAAR HHHCCCCCCCCHHHH	37.62	25368622
610	Phosphorylation	VVKDPATSTSRAARL HHCCCCCCCCHHHHH	26.88	25368622
611	Phosphorylation	VKDPATSTSRAARLQ HCCCCCCCCHHHHHH	20.20	25368622
612	Phosphorylation	KDPATSTSRAARLQI CCCCCCCCHHHHHHH	21.49	25368622
776	Phosphorylation	KLLRVLHSLWSPSVF HHHHHHHHHCCCHHH	27.63	19880383
779	Phosphorylation	RVLHSLWSPSVFQTL HHHHHHCCCHHHHHC	16.76	19880383

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HASTY_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HASTY_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HASTY_ARATH !!

Protein-Protein Interaction

Oops, there are no PPI records of HASTY_ARATH !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.