| UniProt ID | HAKAI_MOUSE | |
|---|---|---|
| UniProt AC | Q9JIY2 | |
| Protein Name | E3 ubiquitin-protein ligase Hakai {ECO:0000305} | |
| Gene Name | Cbll1 {ECO:0000312|MGI:MGI:2144842} | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 491 | |
| Subcellular Localization | Nucleus speckle . Nucleus, nucleoplasm . Cytoplasm . Mainly nuclear with some fraction located in the cytoplasm (PubMed:29547716). ZC3H13 is required to anchor component of the MACOM subcomplex, such as VIRMA, in the nucleus (PubMed:29547716). | |
| Protein Description | E3 ubiquitin-protein ligase that mediates ubiquitination of several tyrosine-phosphorylated Src substrates, including CDH1, CTTN and DOK1. [PubMed: 11836526] | |
| Protein Sequence | MDHTDNELQGTNSSGSLGGLDVRRRIPIKLISKQASKVKPAPRTQRTVSRMPAKAPQGDEEGFDYNEEQRYDCKGGELFGNQRRFPGHLFWDFKINILGEKDDTPVHFCDKCGLPIKVYGRMIPCKHVFCYDCAILHEKKGDKMCPGCSDPVQRIEQCTRGSLFMCSIVQGCKRTYLSQRDLQAHINHRHMRAGKPVTRASLENVHPPIAPPPTDIPDRFIMPPDKHHMSHIPPKQHIMMPPPPLQHVPHEHYNQPHEDIRAPPAELSMAPPPPRSVSQETFRISTRKHSNLITVPIQDDSSSGAREPPPPAPAPAHHHPEYQGQPVVSHPHHIMPPQQHYAPPPPPPPPISHPMPHPPQAAGTPHLVYSQAPPPPMTSAPPPITPPPGHIIAQMPPYMNHPPPGPPPPQHGGPPVTAPPPHHYNPNSLPQFTEDQGTLSPPFTQPGGMSPGIWPAPRGPPPPPRMQGPPSQTPLPGPHHPDQTRYRPYYQ | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 4 | Phosphorylation | ----MDHTDNELQGT ----CCCCCCCCCCC | 35.93 | 25521595 | |
| 16 | Phosphorylation | QGTNSSGSLGGLDVR CCCCCCCCCCCCCHH | 26.28 | 25521595 | |
| 74 | Ubiquitination | EEQRYDCKGGELFGN HHHCEECCCCCCCCC | 68.03 | - | |
| 198 | Phosphorylation | MRAGKPVTRASLENV HHCCCCCCHHHHHCC | 29.10 | 25338131 | |
| 201 | Phosphorylation | GKPVTRASLENVHPP CCCCCHHHHHCCCCC | 32.69 | 28833060 | |
| 278 | Phosphorylation | PPPPRSVSQETFRIS CCCCCCCCCCEEEEE | 24.44 | 27841257 | |
| 281 (in isoform 4) | Phosphorylation | - | 15.58 | 26239621 | |
| 285 | Phosphorylation | SQETFRISTRKHSNL CCCEEEEECCCCCCC | 20.22 | - | |
| 290 | Phosphorylation | RISTRKHSNLITVPI EEECCCCCCCEEEEC | 36.04 | 27681418 | |
| 291 (in isoform 4) | Phosphorylation | - | 34.87 | 26239621 | |
| 294 | Phosphorylation | RKHSNLITVPIQDDS CCCCCCEEEECCCCC | 24.32 | 27681418 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of HAKAI_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of HAKAI_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of HAKAI_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of HAKAI_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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