H2B6_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: H2B6_ARATH
• UniProt AC: O23629
• Protein Name: Histone H2B.6
• Gene Name: H2B
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 150
• Subcellular Localization: Nucleus. Chromosome.
• Protein Description: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling..
• Protein Sequence: MAPRAEKKPAEKKPAAEKPVEEKSKAEKAPAEKKPKAGKKLPKEAGAGGDKKKKMKKKSVETYKIYIFKVLKQVHPDIGISSKAMGIMNSFINDIFEKLASESSKLARYNKKPTITSREIQTAVRLVLPGELAKHAVSEGTKAVTKFTSS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Methylation	------MAPRAEKKP ------CCCHHHCCC	11.42	17691833
2	"N,N-dimethylalanine"	------MAPRAEKKP ------CCCHHHCCC	11.42	-
7	Acetylation	-MAPRAEKKPAEKKP -CCCHHHCCCCCCCC	64.17	17691833
12	Acetylation	AEKKPAEKKPAAEKP HHCCCCCCCCCCCCC	67.19	17691833
13	"N6,N6-dimethyllysine"	EKKPAEKKPAAEKPV HCCCCCCCCCCCCCH	31.24	-
13	Methylation	EKKPAEKKPAAEKPV HCCCCCCCCCCCCCH	31.24	-
28	Acetylation	EEKSKAEKAPAEKKP HHHHHHHCCCHHHCC	65.61	17691833
33	Acetylation	AEKAPAEKKPKAGKK HHCCCHHHCCCCCCC	76.20	17691833
34	Acetylation	EKAPAEKKPKAGKKL HCCCHHHCCCCCCCC	43.16	21311031
39	Acetylation	EKKPKAGKKLPKEAG HHCCCCCCCCCHHHC	56.87	17691833
40	Acetylation	KKPKAGKKLPKEAGA HCCCCCCCCCHHHCC	69.93	17691833
72	Methylation	IYIFKVLKQVHPDIG HHHHHHHHHHCCCCC	53.94	23161681
81	Phosphorylation	VHPDIGISSKAMGIM HCCCCCCCHHHHHHH	22.15	25561503
82	Phosphorylation	HPDIGISSKAMGIMN CCCCCCCHHHHHHHH	23.63	25561503
83	Methylation	PDIGISSKAMGIMNS CCCCCCHHHHHHHHH	35.29	23161681
116	Phosphorylation	YNKKPTITSREIQTA HCCCCCCCHHHHHHH	24.98	25561503
117	Phosphorylation	NKKPTITSREIQTAV CCCCCCCHHHHHHHH	24.86	25561503
134	Methylation	VLPGELAKHAVSEGT HCCHHHHHHHHHHHC	44.73	23161681
138	Phosphorylation	ELAKHAVSEGTKAVT HHHHHHHHHHCHHHH	30.96	25561503

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	HUB1	Q8RXD6	PMID:22199232
-	K	Ubiquitination	E3 ubiquitin ligase	HUB2	Q9C895	PMID:22199232

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of H2B6_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of H2B6_ARATH !!

Protein-Protein Interaction

Oops, there are no PPI records of H2B6_ARATH !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Characterization of post-translational modifications of histone H2B-variants isolated from Arabidopsis thaliana.";
Bergmueller E., Gehrig P.M., Gruissem W.;
J. Proteome Res. 6:3655-3668(2007).
Cited for: ACETYLATION AT LYS-7; LYS-12; LYS-28; LYS-33; LYS-39 AND LYS-40,METHYLATION AT ALA-2, UBIQUITINATION AT LYS-146, AND MASSSPECTROMETRY.
PubMed: 17691833

Methylation

"Characterization of post-translational modifications of histone H2B-variants isolated from Arabidopsis thaliana.";
Bergmueller E., Gehrig P.M., Gruissem W.;
J. Proteome Res. 6:3655-3668(2007).
Cited for: ACETYLATION AT LYS-7; LYS-12; LYS-28; LYS-33; LYS-39 AND LYS-40,METHYLATION AT ALA-2, UBIQUITINATION AT LYS-146, AND MASSSPECTROMETRY.
PubMed: 17691833